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PubMed:8226774 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-181 Sentence denotes Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.
T2 182-352 Sentence denotes The spectrin tetramer, the principal structural element of the red cell membrane skeleton, is formed by stable head-to-head self-association of two spectrin heterodimers.
T3 353-595 Sentence denotes The self-association site appears to be formed by interactions between helices 1 and 2 of beta spectrin repeat 17 of one dimer with helix 3 of alpha spectrin repeat 1 of the other dimer to form two combined alpha-beta triple-helical segments.
T4 596-675 Sentence denotes The head of the heterodimer appears to involve similar intradimer interactions.
T5 676-871 Sentence denotes We describe the first example of an amino acid substitution in helix 1 of this combined alpha-beta triple-helical segment, which, although relatively minor, profoundly impairs tetramer formation.
T6 872-1059 Sentence denotes Strikingly, low angle rotary shadowing electron microscopy of isolated spectrin dimers reveals that this mutation also severely disrupts the head of the heterodimer causing it to be open.
T7 1060-1293 Sentence denotes Following linkage studies which were most consistent with a beta spectrin gene mutation, a nucleotide change was identified in codon 2018, resulting in an Ala-->Gly substitution in the first helical domain of beta spectrin repeat 17.
T8 1294-1413 Sentence denotes Because glycine is a strong helix breaker, this change is predicted to disrupt the conformation of this helical domain.
T9 1414-1654 Sentence denotes Our results indicate that this helical domain must play direct roles in the alpha-beta interdimer interactions that form the self-association site of the tetramer and in the alpha-beta intradimer interactions at the head of the heterodimer.
T1 0-181 Sentence denotes Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.
T2 182-352 Sentence denotes The spectrin tetramer, the principal structural element of the red cell membrane skeleton, is formed by stable head-to-head self-association of two spectrin heterodimers.
T3 353-595 Sentence denotes The self-association site appears to be formed by interactions between helices 1 and 2 of beta spectrin repeat 17 of one dimer with helix 3 of alpha spectrin repeat 1 of the other dimer to form two combined alpha-beta triple-helical segments.
T4 596-675 Sentence denotes The head of the heterodimer appears to involve similar intradimer interactions.
T5 676-871 Sentence denotes We describe the first example of an amino acid substitution in helix 1 of this combined alpha-beta triple-helical segment, which, although relatively minor, profoundly impairs tetramer formation.
T6 872-1059 Sentence denotes Strikingly, low angle rotary shadowing electron microscopy of isolated spectrin dimers reveals that this mutation also severely disrupts the head of the heterodimer causing it to be open.
T7 1060-1293 Sentence denotes Following linkage studies which were most consistent with a beta spectrin gene mutation, a nucleotide change was identified in codon 2018, resulting in an Ala-->Gly substitution in the first helical domain of beta spectrin repeat 17.
T8 1294-1413 Sentence denotes Because glycine is a strong helix breaker, this change is predicted to disrupt the conformation of this helical domain.
T9 1414-1654 Sentence denotes Our results indicate that this helical domain must play direct roles in the alpha-beta interdimer interactions that form the self-association site of the tetramer and in the alpha-beta intradimer interactions at the head of the heterodimer.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 263-271 http://purl.obolibrary.org/obo/MAT_0000032 denotes skeleton
T2 293-297 http://purl.obolibrary.org/obo/MAT_0000294 denotes head
T3 301-305 http://purl.obolibrary.org/obo/MAT_0000294 denotes head
T4 600-604 http://purl.obolibrary.org/obo/MAT_0000294 denotes head
T5 1013-1017 http://purl.obolibrary.org/obo/MAT_0000294 denotes head
T6 1630-1634 http://purl.obolibrary.org/obo/MAT_0000294 denotes head

AIMed

Id Subject Object Predicate Lexical cue
T1 0-17 protein denotes Spectrin cagliari
T2 59-72 protein denotes beta spectrin
T3 443-456 protein denotes beta spectrin
T4 496-510 protein denotes alpha spectrin
T5 1120-1133 protein denotes beta spectrin
T6 1269-1282 protein denotes beta spectrin

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 263-271 Body_part denotes skeleton http://purl.obolibrary.org/obo/MAT_0000032
T2 293-297 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294
T3 301-305 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294
T4 600-604 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294
T5 1013-1017 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294
T6 1630-1634 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1302-1309 OrganismTaxon denotes glycine 3846

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 48-53 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T2 148-159 Body_part denotes erythrocyte http://purl.obolibrary.org/obo/CL_0000232
T3 249-262 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886
T4 263-271 Body_part denotes skeleton http://purl.obolibrary.org/obo/UBERON_0004288
T5 293-297 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T6 301-305 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T7 485-490 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T8 586-594 Body_part denotes segments http://purl.obolibrary.org/obo/UBERON_0000914
T9 600-604 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T10 739-744 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T11 790-797 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914
T12 1013-1017 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T13 1322-1327 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T14 1630-1634 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 148-159 Cell denotes erythrocyte http://purl.obolibrary.org/obo/CL:0000232