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sentences

Id Subject Object Predicate Lexical cue
T1 0-129 Sentence denotes Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.
T2 130-491 Sentence denotes A highly purified and reconstituted hepatic microsomal monooxygenase system, completely free of epoxide hydrase and consisting of cytochrome P-448 from 3-methylcholanthrene-treated rats, NADPH-cytochrome c reductase, phosphatidylcholine, and NADPH, metabolizes benzo (a)pyrene to products highly mutagenic in strains TA 98 and TA 1538 of Salmonella typhimurium.
T3 492-699 Sentence denotes The formation of mutagenic metabolites is completely dependent on the presence of benzo (a)pyrene, NADPH, NADPH-cytochrome c reductase, and cytochrome P-448 and is partially dependent on phosphatidylcholine.
T4 700-811 Sentence denotes Mutation frequency in both strains is linearly related to amount of cytochrome P-448 and to time of incubation.
T5 812-970 Sentence denotes Highly purified cytochrome P-450 from phenobarbital-treated rats is relatively poor in catalyzing the formation of mutagenic metabolites from benzo (a)pyrene.
T6 971-1194 Sentence denotes Addition of 7.5 to 75 units of highly purified epoxide hydrase to the cytochrome P-448-dependent monooxygenase system decreases the number of mutations by approximately 50% and30% in strains TA 1538 and TA 98, respectively.
T7 1195-1399 Sentence denotes Additional amounts of epoxide hydrase (300 units) fail to further suppress mutations, indicating that at least some, but probably not all, of the mutagenic metabolites of benzo (a)pyrene are arene oxides.
T8 1400-1700 Sentence denotes In the absence of a monooxygenase system, mutations induced by benzo (a)pyrene 4,5-oxide are readily quenched by epoxide hydrase, whereas mutations induced by a diol epoxide metabolite of benzo (a)pyrene [(+/-)-7 beta, 8alpha-dihydroxy-9beta, 10beta-epoxy-7,8,9,10-tetrahydrobenzo (a)pyrene] are not.
T9 1701-1841 Sentence denotes Several known and potential phenolic and dihydrodiol metabolites of benzo (a)pyrene are metabolized to products mutagenic in the Salmonella.
T10 1842-2083 Sentence denotes The number of mutations induced per nmol of hemoprotein is approximately 3- to 4-fold higher when trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene replaces benzo (a)pyrene as a substrate for the cytochrome P-448-dependent monooxygenase system.
T11 2084-2274 Sentence denotes Little or no mutagenic activity is observed with trans-dihydrodiols at positions 4,5, 9,10, or 11,12 of the hydrocarbon, either in the absence or presence of the active monooxygenase system.
T12 2275-2661 Sentence denotes Of the 12 possible isomeric monophenols of benzo (a)-pyrene, only 6- and 12-hydroxybenzo (a)pyrene are moderately active bacterial mutagens; 1-, 2-, 3-, 6-, 9-, and 12-hydroxybenzo (a)pyrene are premutagens (i.e. metabolized to mutagenic products); and 4-, 5-, 7-, 8-, 10-, and 11-hydroxybenzo (a)pyrene have little or no mutagenic activity with or without further oxidative metabolism.
T13 2662-2919 Sentence denotes Benzo (a)pyrene 7,8-oxide, a carcinogen on mouse skin, is weakly mutagenic but can be further metabolized to a highly active bacterial mutagen(s), presumably diol epoxide(s), by a combination of epoxide hydrase and the cytochrome P-448 monooxygenase system.
T14 2920-3043 Sentence denotes This is the first example of a direct role of epoxide hydrase in the metabolic activation of a chemical to a toxic product.
T1 0-129 Sentence denotes Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.
T2 130-491 Sentence denotes A highly purified and reconstituted hepatic microsomal monooxygenase system, completely free of epoxide hydrase and consisting of cytochrome P-448 from 3-methylcholanthrene-treated rats, NADPH-cytochrome c reductase, phosphatidylcholine, and NADPH, metabolizes benzo (a)pyrene to products highly mutagenic in strains TA 98 and TA 1538 of Salmonella typhimurium.
T3 492-699 Sentence denotes The formation of mutagenic metabolites is completely dependent on the presence of benzo (a)pyrene, NADPH, NADPH-cytochrome c reductase, and cytochrome P-448 and is partially dependent on phosphatidylcholine.
T4 700-811 Sentence denotes Mutation frequency in both strains is linearly related to amount of cytochrome P-448 and to time of incubation.
T5 812-970 Sentence denotes Highly purified cytochrome P-450 from phenobarbital-treated rats is relatively poor in catalyzing the formation of mutagenic metabolites from benzo (a)pyrene.
T6 971-1194 Sentence denotes Addition of 7.5 to 75 units of highly purified epoxide hydrase to the cytochrome P-448-dependent monooxygenase system decreases the number of mutations by approximately 50% and30% in strains TA 1538 and TA 98, respectively.
T7 1195-1399 Sentence denotes Additional amounts of epoxide hydrase (300 units) fail to further suppress mutations, indicating that at least some, but probably not all, of the mutagenic metabolites of benzo (a)pyrene are arene oxides.
T8 1400-1700 Sentence denotes In the absence of a monooxygenase system, mutations induced by benzo (a)pyrene 4,5-oxide are readily quenched by epoxide hydrase, whereas mutations induced by a diol epoxide metabolite of benzo (a)pyrene [(+/-)-7 beta, 8alpha-dihydroxy-9beta, 10beta-epoxy-7,8,9,10-tetrahydrobenzo (a)pyrene] are not.
T9 1701-1841 Sentence denotes Several known and potential phenolic and dihydrodiol metabolites of benzo (a)pyrene are metabolized to products mutagenic in the Salmonella.
T10 1842-2083 Sentence denotes The number of mutations induced per nmol of hemoprotein is approximately 3- to 4-fold higher when trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene replaces benzo (a)pyrene as a substrate for the cytochrome P-448-dependent monooxygenase system.
T11 2084-2274 Sentence denotes Little or no mutagenic activity is observed with trans-dihydrodiols at positions 4,5, 9,10, or 11,12 of the hydrocarbon, either in the absence or presence of the active monooxygenase system.
T12 2275-2661 Sentence denotes Of the 12 possible isomeric monophenols of benzo (a)-pyrene, only 6- and 12-hydroxybenzo (a)pyrene are moderately active bacterial mutagens; 1-, 2-, 3-, 6-, 9-, and 12-hydroxybenzo (a)pyrene are premutagens (i.e. metabolized to mutagenic products); and 4-, 5-, 7-, 8-, 10-, and 11-hydroxybenzo (a)pyrene have little or no mutagenic activity with or without further oxidative metabolism.
T13 2662-2919 Sentence denotes Benzo (a)pyrene 7,8-oxide, a carcinogen on mouse skin, is weakly mutagenic but can be further metabolized to a highly active bacterial mutagen(s), presumably diol epoxide(s), by a combination of epoxide hydrase and the cytochrome P-448 monooxygenase system.
T14 2920-3043 Sentence denotes This is the first example of a direct role of epoxide hydrase in the metabolic activation of a chemical to a toxic product.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 2711-2715 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 2711-2715 Body_part denotes skin http://purl.obolibrary.org/obo/MAT_0000284

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 22-28 OrganismTaxon denotes pyrene 2917844
T2 42-48 OrganismTaxon denotes pyrene 2917844
T3 311-315 OrganismTaxon denotes rats 10114|10116
T5 400-406 OrganismTaxon denotes pyrene 2917844
T6 468-478 OrganismTaxon denotes Salmonella 590
T7 583-589 OrganismTaxon denotes pyrene 2917844
T8 872-876 OrganismTaxon denotes rats 10114|10116
T10 963-969 OrganismTaxon denotes pyrene 2917844
T11 1375-1381 OrganismTaxon denotes pyrene 2917844
T12 1386-1391 OrganismTaxon denotes arene 529734
T13 1472-1478 OrganismTaxon denotes pyrene 2917844
T14 1597-1603 OrganismTaxon denotes pyrene 2917844
T15 1684-1690 OrganismTaxon denotes pyrene 2917844
T16 1778-1784 OrganismTaxon denotes pyrene 2917844
T17 1830-1840 OrganismTaxon denotes Salmonella 590
T18 1980-1986 OrganismTaxon denotes pyrene 2917844
T19 2005-2011 OrganismTaxon denotes pyrene 2917844
T20 2328-2334 OrganismTaxon denotes pyrene 2917844
T21 2367-2373 OrganismTaxon denotes pyrene 2917844
T22 2459-2465 OrganismTaxon denotes pyrene 2917844
T23 2572-2578 OrganismTaxon denotes pyrene 2917844
T24 2671-2677 OrganismTaxon denotes pyrene 2917844
T25 2705-2710 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2711-2715 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014|http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0002097|http://purl.obolibrary.org/obo/UBERON_0002199