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PubMed:821944 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Immunological evidence for substrate-induced conformational alterations in human carbonic anhydrase B.
T2 103-319 Sentence denotes The inhibition by specific antibody of carbonic anhydrase B activity towards bicarbonate was uncompetitive (Ki 9.5 X 10(-7) M) whereas that of activity towards p-nitrophenylacetate was mixed-type (Ki 9.2 X 10(-7) M).
T3 320-486 Sentence denotes Differences in the immunological reactivity of the enzyme in the presence of the substrates was documented by quantitative precipitin tests and by the Farr technique.
T4 487-690 Sentence denotes In the presence of bicarbonate, nearly half of the antigenic determinants of the enzyme were altered to such an extent that antibodies directed against these determinants in the native form did not bind.
T5 691-831 Sentence denotes This antibody fraction was separated and shown to react with the native enzyme in different molar ratios than the total antibody population.
T6 832-929 Sentence denotes It produced only a very limited inhibition of the activity towards CO2 and p-nitrophenyl acetate.
T7 930-1177 Sentence denotes The immunological reactivity of the enzyme with both the total antibody population and the fraction that is nonreactive in the presence of bicarbonate was identical in the absence of substrates and in the presence of CO2 and p-nitrophenyl acetate.
T8 1178-1369 Sentence denotes It is suggested that the native enzyme form exhibits enzymatic activity towards CO2 and p-nitrophenyl acetate, whereas in the presence of bicarbonate a "conformational adaptation" is induced.
T1 0-102 Sentence denotes Immunological evidence for substrate-induced conformational alterations in human carbonic anhydrase B.
T2 103-319 Sentence denotes The inhibition by specific antibody of carbonic anhydrase B activity towards bicarbonate was uncompetitive (Ki 9.5 X 10(-7) M) whereas that of activity towards p-nitrophenylacetate was mixed-type (Ki 9.2 X 10(-7) M).
T3 320-486 Sentence denotes Differences in the immunological reactivity of the enzyme in the presence of the substrates was documented by quantitative precipitin tests and by the Farr technique.
T4 487-690 Sentence denotes In the presence of bicarbonate, nearly half of the antigenic determinants of the enzyme were altered to such an extent that antibodies directed against these determinants in the native form did not bind.
T5 691-831 Sentence denotes This antibody fraction was separated and shown to react with the native enzyme in different molar ratios than the total antibody population.
T6 832-929 Sentence denotes It produced only a very limited inhibition of the activity towards CO2 and p-nitrophenyl acetate.
T7 930-1177 Sentence denotes The immunological reactivity of the enzyme with both the total antibody population and the fraction that is nonreactive in the presence of bicarbonate was identical in the absence of substrates and in the presence of CO2 and p-nitrophenyl acetate.
T8 1178-1369 Sentence denotes It is suggested that the native enzyme form exhibits enzymatic activity towards CO2 and p-nitrophenyl acetate, whereas in the presence of bicarbonate a "conformational adaptation" is induced.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 75-80 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 783-788 Body_part denotes molar http://purl.obolibrary.org/obo/UBERON_0003655