PubMed:8212965 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	13-38	protein	denotes	transcription factor AP-1
T2	63-74	cell_type	denotes	lymphocytes
T3	520-538	protein	denotes	Phytohemagglutinin
T4	550-561	cell_type	denotes	lymphocytes
T5	675-686	cell_type	denotes	lymphocytes
T6	818-822	protein	denotes	AP-1
T7	847-862	cell_type	denotes	NCL lymphocytes
T8	877-884	cell_type	denotes	DS ones
T9	982-993	cell_type	denotes	fibroblasts
T10	1041-1052	cell_type	denotes	lymphocytes

Id	Subject	Object	Predicate	Lexical cue
S1	0-135	Sentence	denotes	The impaired transcription factor AP-1 DNA binding activity in lymphocytes derived from subjects with some symptoms of premature aging.
S2	136-263	Sentence	denotes	The study of human disorders known as premature aging syndromes may provide insight into the mechanisms of cellular senescence.
S3	264-348	Sentence	denotes	The main feature of cellular senescence in vitro is cessation of cell proliferation.
S4	349-519	Sentence	denotes	Down syndrome (DS) and neuronal ceroid-lypofuscinosis (NCL) are clinically characterized by the premature onset of numerous features normally associated with human aging.
S5	520-728	Sentence	denotes	Phytohemagglutinin stimulated lymphocytes derived from DS subjects showed a statistically significant diminished proliferation capacity in comparison with lymphocytes derived from NCL and healthy individuals.
S6	729-885	Sentence	denotes	We demonstrated, by applying the electrophoretic mobility shift assay, slightly impaired AP-1 DNA binding activity in NCL lymphocytes and strong in DS ones.
S7	886-1116	Sentence	denotes	Our results showed that the same molecular mechanisms of proliferation cessation could exist in fibroblasts characterized by replicative senescence and in lymphocytes derived from individuals with premature aging syndromes (Down).

Id	Subject	Object	Predicate	Lexical cue
C1	102-134	NP	denotes	some symptoms of premature aging
C2	174-199	NP	denotes	premature aging syndromes
C3	243-262	NP	denotes	cellular senescence
C4	284-312	NP	denotes	cellular senescence in vitro
C5	372-408	NP	denotes	neuronal ceroid-lypofuscinosis (NCL)
C6	700-703	NP	denotes	NCL
C7	851-862	NP	denotes	lymphocytes
C8	880-884	NP	denotes	ones
C9	1083-1108	NP	denotes	premature aging syndromes
R1	C2	C1	coref-other	premature aging syndromes,some symptoms of premature aging
R2	C4	C3	coref-ident	cellular senescence in vitro,cellular senescence
R3	C6	C5	coref-ident	NCL,neuronal ceroid-lypofuscinosis (NCL)
R4	C8	C7	coref-pron	ones,lymphocytes
R5	C9	C2	coref-ident	premature aging syndromes,premature aging syndromes

Id	Subject	Object	Predicate	Lexical cue
T1	4-12	other_name	denotes	impaired
T2	13-38	protein_family_or_group	denotes	transcription factor AP-1
T3	63-74	cell_type	denotes	lymphocytes
T4	88-96	multi_cell	denotes	subjects
T5	119-134	other_name	denotes	premature aging
T6	149-164	other_name	denotes	human disorders
T7	174-199	other_name	denotes	premature aging syndromes
T8	243-262	other_name	denotes	cellular senescence
T9	284-303	other_name	denotes	cellular senescence
T10	329-347	other_name	denotes	cell proliferation
T11	349-362	other_name	denotes	Down syndrome
T12	364-366	other_name	denotes	DS
T13	372-402	other_name	denotes	neuronal ceroid-lypofuscinosis
T14	404-407	other_name	denotes	NCL
T15	507-518	other_name	denotes	human aging
T16	520-538	protein_molecule	denotes	Phytohemagglutinin
T17	550-561	cell_type	denotes	lymphocytes
T18	575-586	multi_cell	denotes	DS subjects
T19	675-686	cell_type	denotes	lymphocytes
T20	700-703	other_name	denotes	NCL
T21	708-727	multi_cell	denotes	healthy individuals
T22	762-798	other_name	denotes	electrophoretic mobility shift assay
T23	809-817	other_name	denotes	impaired
T24	818-822	protein_molecule	denotes	AP-1
T25	847-862	cell_type	denotes	NCL lymphocytes
T26	877-884	cell_type	denotes	DS ones
T27	919-939	other_name	denotes	molecular mechanisms
T28	943-966	other_name	denotes	proliferation cessation
T29	982-993	cell_type	denotes	fibroblasts
T30	1011-1033	other_name	denotes	replicative senescence
T31	1041-1052	cell_type	denotes	lymphocytes
T32	1083-1108	other_name	denotes	premature aging syndromes
T33	1110-1114	other_name	denotes	Down