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PubMed:819436 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes Temperature dependence of cytochrome P-450 reduction.
T2 54-128 Sentence denotes A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction.
T3 129-248 Sentence denotes The NADPH-dependent reduction of rat hepatic microsomal cytochrome P-450 has been studied as a function of temperature.
T4 249-388 Sentence denotes In the temperature range 4-37 degrees the reduction reaction was found to be biphasic and composed of two concurrent first order processes.
T5 389-541 Sentence denotes This phenomenon was observed with microsomes from untreated and phenobarbital-induced animals in the presence or absence of exogenous Type I substrates.
T6 542-690 Sentence denotes The amount of cytochrome P-450 reduced in the fast phase comprised approximately 70% of the total cytochrome P-450 at temperatures above 20 degrees.
T7 691-910 Sentence denotes The temperature dependence of the fast phase was unusual for a membrane-bound enzyme system in that it lacked a discontinuity in the Arrhenius plot at a presumed phase transition temperature for the microsomal membrane.
T8 911-1057 Sentence denotes The slow phase of reduction behaved in a normal fashion for a membrane-bound enzyme system with a break in the Arrhenius plot at about 20 degrees.
T9 1058-1630 Sentence denotes The data presented here combined with previous observations which include (a) the ratio of cytochrome P-450 to NADPH cytochrome P-450 reductase (NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) is 20:1, (b) the catalytic portion of the reductase molecule probably protrudes above the surface of the membrane, and (c) the cytochrome P-450 molecules are presumably embedded in the membrane support the hypothesis that the hepatic microsomal drug-metabolizing system exists as clusters with most of the cytochrome P-450 molecules arranged about a central reductase molecule.
T10 1631-1807 Sentence denotes This central flavoprotein reductase is able to randomly reduce those cytochrome P-450 molecules within the cluster without translational motion through the microsomal membrane.
T11 1808-1922 Sentence denotes The slow phase of reduction represents the reduction of those molecules not directly associated with the clusters.
T1 0-53 Sentence denotes Temperature dependence of cytochrome P-450 reduction.
T2 54-128 Sentence denotes A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction.
T3 129-248 Sentence denotes The NADPH-dependent reduction of rat hepatic microsomal cytochrome P-450 has been studied as a function of temperature.
T4 249-388 Sentence denotes In the temperature range 4-37 degrees the reduction reaction was found to be biphasic and composed of two concurrent first order processes.
T5 389-541 Sentence denotes This phenomenon was observed with microsomes from untreated and phenobarbital-induced animals in the presence or absence of exogenous Type I substrates.
T6 542-690 Sentence denotes The amount of cytochrome P-450 reduced in the fast phase comprised approximately 70% of the total cytochrome P-450 at temperatures above 20 degrees.
T7 691-910 Sentence denotes The temperature dependence of the fast phase was unusual for a membrane-bound enzyme system in that it lacked a discontinuity in the Arrhenius plot at a presumed phase transition temperature for the microsomal membrane.
T8 911-1057 Sentence denotes The slow phase of reduction behaved in a normal fashion for a membrane-bound enzyme system with a break in the Arrhenius plot at about 20 degrees.
T9 1058-1630 Sentence denotes The data presented here combined with previous observations which include (a) the ratio of cytochrome P-450 to NADPH cytochrome P-450 reductase (NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) is 20:1, (b) the catalytic portion of the reductase molecule probably protrudes above the surface of the membrane, and (c) the cytochrome P-450 molecules are presumably embedded in the membrane support the hypothesis that the hepatic microsomal drug-metabolizing system exists as clusters with most of the cytochrome P-450 molecules arranged about a central reductase molecule.
T10 1631-1807 Sentence denotes This central flavoprotein reductase is able to randomly reduce those cytochrome P-450 molecules within the cluster without translational motion through the microsomal membrane.
T11 1808-1922 Sentence denotes The slow phase of reduction represents the reduction of those molecules not directly associated with the clusters.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 162-165 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 754-762 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 901-909 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T7 973-981 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T10 1358-1366 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T13 1438-1446 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T16 1798-1806 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 523-529 Cell denotes Type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138