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PubMed:8191547 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 6-27 protein denotes aldosterone receptors
T2 119-151 cell_type denotes extra-renal, nonepithelial cells
T3 160-179 cell_type denotes smooth muscle cells
T4 210-227 cell_type denotes human lymphocytes
T5 431-454 protein denotes sodium/proton-exchanger
T6 1215-1232 cell_type denotes human lymphocytes
T7 1423-1439 protein denotes receptor protein

genia-medco-coref

Id Subject Object Predicate Lexical cue
C3 78-95 NP denotes the cell membrane
C2 65-95 NP denotes the level of the cell membrane
C1 29-95 NP denotes specificity-conferring mechanism at the level of the cell membrane
C4 210-227 NP denotes human lymphocytes
C5 242-261 NP denotes increasing evidence
C6 262-266 NP denotes that
C7 458-475 NP denotes the cell membrane
C8 560-571 NP denotes 1-2 minutes
C9 612-660 NP denotes the inositol-1,4,5-trisphosphate/calcium pathway
C10 661-666 NP denotes which
C11 681-707 NP denotes the same rapid time course
C12 753-771 NP denotes genomic mechanisms
C13 773-778 NP denotes which
C15 871-874 NP denotes its
C14 871-892 NP denotes its rapid time course
C16 923-958 NP denotes this new pathway for steroid action
C18 1215-1232 NP denotes human lymphocytes
C17 1192-1232 NP denotes the plasma membrane of human lymphocytes
C19 1233-1238 NP denotes which
C20 1244-1324 NP denotes pharmacological (aldosterone specificity) and kinetic (high turnover) properties
C21 1340-1345 NP denotes those
C22 1382-1396 NP denotes the same cells
C23 1493-1510 NP denotes The present paper
C24 1610-1612 NP denotes It
C26 1700-1718 NP denotes the membrane level
C25 1627-1718 NP denotes a novel specificity-conferring mechanism for mineralocorticoid action at the membrane level
R1 C6 C5 coref-relat that,increasing evidence
R2 C7 C3 coref-ident the cell membrane,the cell membrane
R3 C10 C9 coref-relat which,"the inositol-1,4,5-trisphosphate/calcium pathway"
R4 C11 C8 coref-ident the same rapid time course,1-2 minutes
R5 C13 C12 coref-relat which,genomic mechanisms
R6 C15 C11 coref-ident its,the same rapid time course
R7 C14 C9 coref-pron its rapid time course,"the inositol-1,4,5-trisphosphate/calcium pathway"
R8 C16 C9 coref-ident this new pathway for steroid action,"the inositol-1,4,5-trisphosphate/calcium pathway"
R9 C18 C4 coref-ident human lymphocytes,human lymphocytes
R10 C19 C17 coref-relat which,the plasma membrane of human lymphocytes
R11 C21 C20 coref-pron those,pharmacological (aldosterone specificity) and kinetic (high turnover) properties
R12 C22 C18 coref-ident the same cells,human lymphocytes
R13 C24 C23 coref-pron It,The present paper
R14 C26 C2 coref-ident the membrane level,the level of the cell membrane
R15 C25 C1 coref-ident a novel specificity-conferring mechanism for mineralocorticoid action at the membrane level,specificity-conferring mechanism at the level of the cell membrane

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-96 Sentence denotes Novel aldosterone receptors: specificity-conferring mechanism at the level of the cell membrane.
S2 97-398 Sentence denotes Functional studies in extra-renal, nonepithelial cells such as smooth muscle cells and more recently circulating human lymphocytes have provided increasing evidence that aldosterone produces not only classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements.
S3 399-572 Sentence denotes These involve activation of the sodium/proton-exchanger of the cell membrane at very low, physiological concentrations of aldosterone with an acute onset within 1-2 minutes.
S4 573-708 Sentence denotes A second messenger cascade involved is the inositol-1,4,5-trisphosphate/calcium pathway which responds over the same rapid time course.
S5 709-855 Sentence denotes Such changes clearly cannot be explained by genomic mechanisms, which are responsible for later effects than the membrane-related rapid responses.
S6 856-1138 Sentence denotes In addition to its rapid time course the unique characteristics of this new pathway for steroid action include a 10000-fold selectivity for aldosterone over cortisol and the ineffectiveness of spironolactones, classical mineralocorticoid antagonists, as antagonists of the response.
S7 1139-1397 Sentence denotes Subsequently binding sites have been demonstrated in the plasma membrane of human lymphocytes which show pharmacological (aldosterone specificity) and kinetic (high turnover) properties identical with those of the rapid aldosterone effects in the same cells.
S8 1398-1492 Sentence denotes SDS-PAGE analysis of the receptor protein has shown a molecular weight of approximately 50 kD.
S9 1493-1609 Sentence denotes The present paper reviews the data supporting a new, two-step model for non-genomic and genomic aldosterone effects.
S10 1610-1719 Sentence denotes It also suggests a novel specificity-conferring mechanism for mineralocorticoid action at the membrane level.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 6-27 protein_family_or_group denotes aldosterone receptors
T2 82-95 cell_component denotes cell membrane
T3 119-151 cell_type denotes extra-renal, nonepithelial cells
T4 160-179 cell_type denotes smooth muscle cells
T5 210-227 cell_type denotes human lymphocytes
T6 267-278 lipid denotes aldosterone
T7 362-397 other_name denotes transmembrane electrolyte movements
T8 431-454 protein_family_or_group denotes sodium/proton-exchanger
T9 462-475 cell_component denotes cell membrane
T10 521-532 lipid denotes aldosterone
T11 575-599 other_name denotes second messenger cascade
T12 616-644 lipid denotes inositol-1,4,5-trisphosphate
T13 644-652 atom denotes /calcium
T14 753-771 other_name denotes genomic mechanisms
T15 822-854 other_name denotes membrane-related rapid responses
T16 996-1007 lipid denotes aldosterone
T17 1013-1021 lipid denotes cortisol
T18 1049-1064 other_organic_compound denotes spironolactones
T19 1076-1093 lipid denotes mineralocorticoid
T20 1196-1211 cell_component denotes plasma membrane
T21 1215-1232 cell_type denotes human lymphocytes
T22 1261-1272 lipid denotes aldosterone
T23 1359-1370 lipid denotes aldosterone
T24 1398-1415 other_name denotes SDS-PAGE analysis
T25 1423-1439 protein_family_or_group denotes receptor protein
T26 1452-1468 other_name denotes molecular weight
T27 1486-1491 other_name denotes 50 kD
T28 1589-1600 lipid denotes aldosterone
T29 1635-1667 other_name denotes specificity-conferring mechanism
T30 1672-1696 other_name denotes mineralocorticoid action
T31 1704-1718 other_name denotes membrane level