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PubMed:8189531 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-36 cell_type denotes Central nervous system-derived cells
T2 161-164 DNA denotes TAR
T3 196-199 protein denotes Tat
T4 205-216 protein denotes Tat protein
T5 289-309 DNA denotes long terminal repeat
T6 416-437 DNA denotes transcription element
T7 438-441 DNA denotes TAR
T8 443-465 cell_type denotes astrocytic glial cells
T9 474-477 DNA denotes TAR
T10 565-568 protein denotes Tat
T11 599-613 DNA denotes viral enhancer
T12 680-700 protein denotes transcription factor
T13 725-735 protein denotes NF-kappa B
T14 775-788 cell_type denotes T lymphocytes
T15 790-793 protein denotes Tat
T16 826-840 DNA denotes kappa B domain
T17 879-882 DNA denotes TAR
T18 907-917 cell_type denotes astrocytes
T19 967-999 protein denotes kappa B-specific binding factors
T20 1011-1033 cell_type denotes human glial astrocytes
T21 1064-1074 protein denotes NF-kappa B
T22 1153-1156 protein denotes Tat
T23 1193-1203 protein denotes NF-kappa B
T24 1209-1223 cell_line denotes Jurkat T cells
T25 1280-1321 protein denotes astrocyte-derived kappa B-binding factors
T26 1352-1378 DNA denotes HIV-1 long terminal repeat
T27 1424-1438 DNA denotes kappa B domain
T28 1450-1453 DNA denotes TAR
T29 1638-1677 protein denotes central nervous system-enriched kappa B
T30 1678-1698 protein denotes transcription factor

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 45-71 NP denotes a kappa B-binding activity
C2 72-76 NP denotes that
C3 86-135 NP denotes human immunodeficiency virus type 1 transcription
C5 196-199 NP denotes Tat
C4 161-199 NP denotes TAR-independent transactivation by Tat
C6 201-263 NP denotes The Tat protein of human immunodeficiency virus type 1 (HIV-1)
C7 289-332 NP denotes long terminal repeat-directed transcription
C8 395-398 NP denotes Tat
C10 509-528 NP denotes HIV-1 transcription
C11 532-535 NP denotes Tat
C9 474-535 NP denotes TAR-independent transactivation of HIV-1 transcription by Tat
C12 595-613 NP denotes the viral enhancer
C13 615-763 NP denotes a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B (NF-kappa B) present in many cell types
C14 822-840 NP denotes the kappa B domain
C15 1011-1033 NP denotes human glial astrocytes
C16 1034-1038 NP denotes that
C17 1051-1074 NP denotes prototypical NF-kappa B
C18 1180-1203 NP denotes prototypical NF-kappa B
C19 1331-1378 NP denotes transcription of the HIV-1 long terminal repeat
C20 1420-1438 NP denotes the kappa B domain
C21 1450-1504 NP denotes TAR-independent transactivation of HIV-1 transcription
C22 1531-1567 NP denotes an astrocyte factor-dependent manner
C23 1568-1573 NP denotes which
R1 C2 C1 coref-relat that,a kappa B-binding activity
R2 C6 C5 coref-ident The Tat protein of human immunodeficiency virus type 1 (HIV-1),Tat
R3 C8 C5 coref-ident Tat,Tat
R4 C10 C3 coref-ident HIV-1 transcription,human immunodeficiency virus type 1 transcription
R5 C11 C8 coref-ident Tat,Tat
R6 C9 C4 coref-ident TAR-independent transactivation of HIV-1 transcription by Tat,TAR-independent transactivation by Tat
R7 C13 C12 coref-appos a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B (NF-kappa B) present in many cell types,the viral enhancer
R8 C16 C15 coref-relat that,human glial astrocytes
R9 C18 C17 coref-ident prototypical NF-kappa B,prototypical NF-kappa B
R10 C19 C7 coref-ident transcription of the HIV-1 long terminal repeat,long terminal repeat-directed transcription
R11 C20 C14 coref-ident the kappa B domain,the kappa B domain
R12 C21 C9 coref-ident TAR-independent transactivation of HIV-1 transcription,TAR-independent transactivation of HIV-1 transcription by Tat
R13 C23 C22 coref-relat which,an astrocyte factor-dependent manner

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-200 Sentence denotes Central nervous system-derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR-independent transactivation by Tat.
S2 201-333 Sentence denotes The Tat protein of human immunodeficiency virus type 1 (HIV-1) is a potent activator of long terminal repeat-directed transcription.
S3 334-536 Sentence denotes While in most cell types, activation requires interaction of Tat with the unusual transcription element TAR, astrocytic glial cells support TAR-independent transactivation of HIV-1 transcription by Tat.
S4 537-789 Sentence denotes This alternative pathway of Tat activation is mediated by the viral enhancer, a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B (NF-kappa B) present in many cell types, including T lymphocytes.
S5 790-918 Sentence denotes Tat transactivation mediated by the kappa B domain is sufficient to allow replication of TAR-deleted mutant HIV-1 in astrocytes.
S6 919-1075 Sentence denotes The present study demonstrates the existence of kappa B-specific binding factors present in human glial astrocytes that differ from prototypical NF-kappa B.
S7 1076-1231 Sentence denotes The novel astrocyte-derived kappa B-binding activity is retained on an HIV-1 Tat affinity column, while prototypical NF-kappa B from Jurkat T cells is not.
S8 1232-1439 Sentence denotes In vitro transcription studies demonstrate that astrocyte-derived kappa B-binding factors activate transcription of the HIV-1 long terminal repeat and that this activation is dependent on the kappa B domain.
S9 1440-1615 Sentence denotes Moreover, TAR-independent transactivation of HIV-1 transcription is reproduced in vitro in an astrocyte factor-dependent manner which correlates with kappa B-binding activity.
S10 1616-1750 Sentence denotes The importance of the central nervous system-enriched kappa B transcription factor in the regulation of HIV-1 expression is discussed.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-22 body_part denotes Central nervous system
T2 47-71 other_name denotes kappa B-binding activity
T3 86-121 virus denotes human immunodeficiency virus type 1
T4 161-164 DNA_domain_or_region denotes TAR
T5 196-199 protein_molecule denotes Tat
T6 205-216 protein_molecule denotes Tat protein
T7 220-255 virus denotes human immunodeficiency virus type 1
T8 257-262 virus denotes HIV-1
T9 289-309 DNA_domain_or_region denotes long terminal repeat
T10 416-437 DNA_family_or_group denotes transcription element
T11 438-441 DNA_domain_or_region denotes TAR
T12 443-465 cell_type denotes astrocytic glial cells
T13 474-477 DNA_domain_or_region denotes TAR
T14 509-514 virus denotes HIV-1
T15 565-568 protein_molecule denotes Tat
T16 599-613 DNA_domain_or_region denotes viral enhancer
T17 680-700 protein_family_or_group denotes transcription factor
T18 725-735 protein_molecule denotes NF-kappa B
T19 775-788 cell_type denotes T lymphocytes
T20 790-793 protein_molecule denotes Tat
T21 826-840 DNA_domain_or_region denotes kappa B domain
T22 879-882 DNA_domain_or_region denotes TAR
T23 898-903 virus denotes HIV-1
T24 907-917 cell_type denotes astrocytes
T25 967-999 protein_family_or_group denotes kappa B-specific binding factors
T26 1011-1033 cell_type denotes human glial astrocytes
T27 1064-1074 protein_molecule denotes NF-kappa B
T28 1104-1128 other_name denotes kappa B-binding activity
T29 1147-1152 virus denotes HIV-1
T30 1153-1156 protein_molecule denotes Tat
T31 1193-1203 protein_molecule denotes NF-kappa B
T32 1209-1223 cell_line denotes Jurkat T cells
T33 1280-1321 protein_family_or_group denotes astrocyte-derived kappa B-binding factors
T34 1352-1357 virus denotes HIV-1
T35 1424-1438 DNA_domain_or_region denotes kappa B domain
T36 1450-1453 DNA_domain_or_region denotes TAR
T37 1485-1490 virus denotes HIV-1
T38 1534-1567 other_name denotes astrocyte factor-dependent manner
T39 1590-1614 other_name denotes kappa B-binding activity
T40 1638-1660 body_part denotes central nervous system
T41 1678-1698 protein_family_or_group denotes transcription factor
T42 1720-1725 virus denotes HIV-1