PubMed:8184011 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":14,"end":36},"obj":"protein"},{"id":"T2","span":{"begin":40,"end":66},"obj":"cell_type"},{"id":"T3","span":{"begin":99,"end":121},"obj":"protein"},{"id":"T4","span":{"begin":123,"end":133},"obj":"protein"},{"id":"T5","span":{"begin":140,"end":172},"obj":"protein"},{"id":"T6","span":{"begin":358,"end":368},"obj":"protein"},{"id":"T7","span":{"begin":372,"end":405},"obj":"cell_line"},{"id":"T8","span":{"begin":410,"end":444},"obj":"cell_type"},{"id":"T9","span":{"begin":645,"end":655},"obj":"protein"},{"id":"T10","span":{"begin":659,"end":706},"obj":"cell_line"},{"id":"T11","span":{"begin":887,"end":897},"obj":"protein"},{"id":"T12","span":{"begin":1091,"end":1101},"obj":"protein"},{"id":"T13","span":{"begin":1163,"end":1194},"obj":"protein"}],"text":"Activation of nuclear factor kappa B in human lymphoblastoid cells by low-dose ionizing radiation.\nNuclear factor kappa B (NF-kappa B) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes. Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kappa B in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known. The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kappa B in EBV-transformed 244B human lymphoblastoid cells. These results are in a dose range where the viability of the cells remains very high. After exposure to 137Cs gamma rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kappa B was seen at 8 h after a 0.5-Gy exposure. Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures. However, for each time examined, the expression of NF-kappa B was maximum after the 0.5-Gy exposure. The expression of the p50 and p65 NF-kappa B subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy."}

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