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PubMed:8182938 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 159-284 DRI_Background denotes A basis for differentiation therapy of leukemias is provided by knowledge of agents which induce specific lineage maturation.
T2 285-417 DRI_Background denotes All-trans retinoic acid (RA) induces differentiation of HL60 cells to neutrophils and is used to treat acute promyelocytic leukemia.
T3 418-603 DRI_Approach denotes We observed that RA did not induced neutrophil differentiation in serum-free grown HL60 cells whereas 50 nM 1 alpha,25-dihydroxyvitamin D3 (D3) induced maximal monocyte differentiation.
T4 701-807 DRI_Approach denotes Cells treated with 5 nM D3 showed little response, but differentiated maximally with 5 nM D3 and 10 nM RA.
T5 808-902 DRI_Approach denotes The D3 analogs MC903, EB1089 and KH1060 were more potent inducers of monocyte differentiation.
T6 903-1012 DRI_Background denotes The extent to which analog activity was increased after cotreatment with RA was inversely related to potency.
T7 1013-1131 DRI_Approach denotes Twenty-four hour treatment with 10 nM RA primed cells for response to 5 nM D3; the reverse sequence being ineffective.
T8 1132-1314 DRI_Outcome denotes Priming with 10 nM RA, or subsequent treatment with D3 (5 nM), did not alter expression of mRNAs encoding receptors for D3 (VDR), RA (RAR alpha) or 9-CIS RA (RXR alpha, beta, gamma).
T9 1315-1543 DRI_Background denotes That RA promotes both neutrophil and monocyte differentiation has implications for the use of RA and D3 in treatment of leukemias and provides insight into mechanisms whereby RAR, VDR and RXR facilitate monocyte differentiation.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1490-1493 gene:10966 denotes RAR
T1 1435-1444 disease:C0023418 denotes leukemias
T2 1490-1493 gene:5914 denotes RAR
T3 1435-1444 disease:C0023418 denotes leukemias
R1 T0 T1 associated_with RAR,leukemias
R2 T2 T3 associated_with RAR,leukemias

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 104-139 cell_line denotes human promyeloid leukemia cell line
T2 140-144 cell_line denotes HL60
T3 148-157 cell_type denotes monocytes
T4 341-351 cell_line denotes HL60 cells
T5 355-366 cell_type denotes neutrophils
T6 484-511 cell_line denotes serum-free grown HL60 cells
T7 1051-1066 cell_line denotes RA primed cells
T8 1223-1228 RNA denotes mRNAs
T9 1238-1247 protein denotes receptors
T10 1256-1259 protein denotes VDR
T11 1266-1275 protein denotes RAR alpha
T12 1290-1312 protein denotes RXR alpha, beta, gamma
T13 1495-1498 protein denotes VDR
T14 1503-1506 protein denotes RXR

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-23 NP denotes All-trans retinoic acid
C2 100-144 NP denotes the human promyeloid leukemia cell line HL60
C3 236-242 NP denotes agents
C4 243-248 NP denotes which
C5 285-313 NP denotes All-trans retinoic acid (RA)
C6 341-351 NP denotes HL60 cells
C7 355-366 NP denotes neutrophils
C8 435-437 NP denotes RA
C9 675-699 NP denotes monocyte differentiation
C10 720-727 NP denotes 5 nM D3
C11 786-793 NP denotes 5 nM D3
C12 798-806 NP denotes 10 nM RA
C13 877-901 NP denotes monocyte differentiation
C14 903-913 NP denotes The extent
C15 917-922 NP denotes which
C16 976-978 NP denotes RA
C17 1045-1066 NP denotes 10 nM RA primed cells
C18 1083-1090 NP denotes 5 nM D3
C19 1145-1153 NP denotes 10 nM RA
C20 1184-1193 NP denotes D3 (5 nM)
C21 1320-1322 NP denotes RA
C22 1337-1347 NP denotes neutrophil
C23 1352-1376 NP denotes monocyte differentiation
C24 1409-1411 NP denotes RA
C25 1471-1481 NP denotes mechanisms
C26 1482-1489 NP denotes whereby
C27 1518-1542 NP denotes monocyte differentiation
R1 C4 C3 coref-relat which,agents
R2 C5 C1 coref-ident All-trans retinoic acid (RA),All-trans retinoic acid
R3 C6 C2 coref-ident HL60 cells,the human promyeloid leukemia cell line HL60
R4 C8 C5 coref-ident RA,All-trans retinoic acid (RA)
R5 C11 C10 coref-ident 5 nM D3,5 nM D3
R6 C13 C9 coref-ident monocyte differentiation,monocyte differentiation
R7 C15 C14 coref-relat which,The extent
R8 C16 C8 coref-ident RA,RA
R9 C17 C15 coref-ident 10 nM RA primed cells,which
R10 C18 C11 coref-ident 5 nM D3,5 nM D3
R11 C19 C17 coref-ident 10 nM RA,10 nM RA primed cells
R12 C20 C18 coref-ident D3 (5 nM),5 nM D3
R13 C21 C16 coref-ident RA,RA
R14 C22 C7 coref-ident neutrophil,neutrophils
R15 C23 C13 coref-ident monocyte differentiation,monocyte differentiation
R16 C24 C21 coref-ident RA,RA
R17 C26 C25 coref-relat whereby,mechanisms
R18 C27 C23 coref-ident monocyte differentiation,monocyte differentiation

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-158 Sentence denotes All-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes.
S2 159-284 Sentence denotes A basis for differentiation therapy of leukemias is provided by knowledge of agents which induce specific lineage maturation.
S3 285-417 Sentence denotes All-trans retinoic acid (RA) induces differentiation of HL60 cells to neutrophils and is used to treat acute promyelocytic leukemia.
S4 418-603 Sentence denotes We observed that RA did not induced neutrophil differentiation in serum-free grown HL60 cells whereas 50 nM 1 alpha,25-dihydroxyvitamin D3 (D3) induced maximal monocyte differentiation.
S5 604-700 Sentence denotes Increasing RA concentrations reduced the D3 concentration required for monocyte differentiation.
S6 701-807 Sentence denotes Cells treated with 5 nM D3 showed little response, but differentiated maximally with 5 nM D3 and 10 nM RA.
S7 808-902 Sentence denotes The D3 analogs MC903, EB1089 and KH1060 were more potent inducers of monocyte differentiation.
S8 903-1012 Sentence denotes The extent to which analog activity was increased after cotreatment with RA was inversely related to potency.
S9 1013-1131 Sentence denotes Twenty-four hour treatment with 10 nM RA primed cells for response to 5 nM D3; the reverse sequence being ineffective.
S10 1132-1314 Sentence denotes Priming with 10 nM RA, or subsequent treatment with D3 (5 nM), did not alter expression of mRNAs encoding receptors for D3 (VDR), RA (RAR alpha) or 9-CIS RA (RXR alpha, beta, gamma).
S11 1315-1543 Sentence denotes That RA promotes both neutrophil and monocyte differentiation has implications for the use of RA and D3 in treatment of leukemias and provides insight into mechanisms whereby RAR, VDR and RXR facilitate monocyte differentiation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-23 other_organic_compound denotes All-trans retinoic acid
T2 28-58 lipid denotes 1 alpha,25-dihydroxyvitamin D3
T3 81-96 other_name denotes differentiation
T4 104-139 cell_line denotes human promyeloid leukemia cell line
T5 140-144 cell_line denotes HL60
T6 148-157 cell_type denotes monocytes
T7 171-186 other_name denotes differentiation
T8 198-207 other_name denotes leukemias
T9 285-308 other_organic_compound denotes All-trans retinoic acid
T10 310-312 other_organic_compound denotes RA
T11 322-337 other_name denotes differentiation
T12 341-351 cell_line denotes HL60 cells
T13 355-366 cell_type denotes neutrophils
T14 388-416 other_name denotes acute promyelocytic leukemia
T15 435-437 other_organic_compound denotes RA
T16 454-464 other_name denotes neutrophil
T17 465-480 other_name denotes differentiation
T18 484-500 cell_line denotes serum-free grown
T19 501-511 cell_line denotes HL60 cells
T20 526-556 lipid denotes 1 alpha,25-dihydroxyvitamin D3
T21 558-560 lipid denotes D3
T22 587-602 other_name denotes differentiation
T23 615-617 other_organic_compound denotes RA
T24 645-647 lipid denotes D3
T25 675-699 other_name denotes monocyte differentiation
T26 725-727 lipid denotes D3
T27 791-793 lipid denotes D3
T28 804-806 other_organic_compound denotes RA
T29 812-814 lipid denotes D3
T30 823-828 other_organic_compound denotes MC903
T31 830-836 other_organic_compound denotes EB1089
T32 841-847 other_organic_compound denotes KH1060
T33 877-901 other_name denotes monocyte differentiation
T34 923-938 other_name denotes analog activity
T35 976-978 other_organic_compound denotes RA
T36 1051-1053 other_organic_compound denotes RA
T37 1088-1090 lipid denotes D3
T38 1151-1153 other_organic_compound denotes RA
T39 1184-1186 lipid denotes D3
T40 1223-1228 RNA_family_or_group denotes mRNAs
T41 1238-1247 protein_family_or_group denotes receptors
T42 1252-1254 lipid denotes D3
T43 1256-1259 protein_family_or_group denotes VDR
T44 1262-1264 other_organic_compound denotes RA
T45 1266-1275 protein_molecule denotes RAR alpha
T46 1280-1285 other_organic_compound denotes 9-CIS
T47 1286-1288 other_organic_compound denotes RA
T48 1320-1322 other_organic_compound denotes RA
T49 1337-1347 other_name denotes neutrophil
T50 1352-1376 other_name denotes monocyte differentiation
T51 1409-1411 other_organic_compound denotes RA
T52 1416-1418 lipid denotes D3
T53 1435-1444 other_name denotes leukemias
T54 1495-1498 protein_family_or_group denotes VDR
T55 1503-1506 protein_family_or_group denotes RXR
T56 1518-1542 other_name denotes monocyte differentiation