PubMed:8179594
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 69-89 | DNA | denotes | proto-oncogene c-fos |
| T2 | 95-115 | protein | denotes | transcription factor |
| T3 | 116-120 | protein | denotes | AP-1 |
| T4 | 187-201 | protein | denotes | growth factors |
| T5 | 279-283 | protein | denotes | AP-1 |
| T6 | 313-333 | protein | denotes | protein heterodimers |
| T7 | 349-369 | DNA | denotes | proto-oncogene c-fos |
| T8 | 374-384 | RNA | denotes | c-jun mRNA |
| T9 | 445-459 | protein | denotes | growth factors |
| T10 | 553-569 | protein | denotes | protein kinase C |
| T11 | 595-615 | RNA | denotes | c-fos and c-jun mRNA |
| T12 | 785-795 | RNA | denotes | c-fos mRNA |
| T13 | 799-819 | cell_line | denotes | human Jurkat T cells |
| T14 | 901-911 | RNA | denotes | c-fos mRNA |
| T15 | 1181-1191 | RNA | denotes | c-fos mRNA |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 11-28 | NP | denotes | alpha-lipoic acid |
| C3 | 33-51 | NP | denotes | dihydrolipoic acid |
| C4 | 55-89 | NP | denotes | expression of proto-oncogene c-fos |
| C1 | 0-89 | NP | denotes | Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos |
| C5 | 345-384 | NP | denotes | the proto-oncogene c-fos and c-jun mRNA |
| C6 | 385-390 | NP | denotes | whose |
| C7 | 425-428 | NP | denotes | TPA |
| C8 | 503-526 | NP | denotes | reactive oxygen species |
| C9 | 545-548 | NP | denotes | TPA |
| C10 | 644-667 | NP | denotes | reactive oxygen species |
| C12 | 694-711 | NP | denotes | alpha-lipoic acid |
| C13 | 716-763 | NP | denotes | dihydrolipoic acid (natural thiol antioxidants) |
| C14 | 767-795 | NP | denotes | the expression of c-fos mRNA |
| C11 | 679-795 | NP | denotes | the effects of alpha-lipoic acid and dihydrolipoic acid (natural thiol antioxidants) on the expression of c-fos mRNA |
| C15 | 799-819 | NP | denotes | human Jurkat T cells |
| C16 | 826-831 | NP | denotes | cells |
| C17 | 855-873 | NP | denotes | dihydrolipoic acid |
| C18 | 883-911 | NP | denotes | the expression of c-fos mRNA |
| C19 | 958-961 | NP | denotes | TPA |
| C20 | 1015-1032 | NP | denotes | alpha-lipoic acid |
| C21 | 1047-1061 | NP | denotes | the expression |
| C22 | 1108-1116 | NP | denotes | the idea |
| C23 | 1117-1121 | NP | denotes | that |
| C24 | 1163-1191 | NP | denotes | the expression of c-fos mRNA |
| R1 | C6 | C5 | coref-relat | whose,the proto-oncogene c-fos and c-jun mRNA |
| R2 | C9 | C7 | coref-ident | TPA,TPA |
| R3 | C10 | C8 | coref-ident | reactive oxygen species,reactive oxygen species |
| R4 | C12 | C2 | coref-ident | alpha-lipoic acid,alpha-lipoic acid |
| R5 | C13 | C3 | coref-ident | dihydrolipoic acid (natural thiol antioxidants),dihydrolipoic acid |
| R6 | C14 | C4 | coref-ident | the expression of c-fos mRNA,expression of proto-oncogene c-fos |
| R7 | C11 | C1 | coref-ident | the effects of alpha-lipoic acid and dihydrolipoic acid (natural thiol antioxidants) on the expression of c-fos mRNA,Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos |
| R8 | C16 | C15 | coref-ident | cells,human Jurkat T cells |
| R9 | C17 | C13 | coref-ident | dihydrolipoic acid,dihydrolipoic acid (natural thiol antioxidants) |
| R10 | C18 | C14 | coref-ident | the expression of c-fos mRNA,the expression of c-fos mRNA |
| R11 | C19 | C9 | coref-ident | TPA,TPA |
| R12 | C20 | C12 | coref-ident | alpha-lipoic acid,alpha-lipoic acid |
| R13 | C21 | C18 | coref-ident | the expression,the expression of c-fos mRNA |
| R14 | C23 | C22 | coref-relat | that,the idea |
| R15 | C24 | C18 | coref-ident | the expression of c-fos mRNA,the expression of c-fos mRNA |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-90 | Sentence | denotes | Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos. |
| S2 | 91-274 | Sentence | denotes | The transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-tetradecanoyl-phorbol-13 acetate (TPA). |
| S3 | 275-460 | Sentence | denotes | The AP-1 complex consists of distinct protein heterodimers encoded by the proto-oncogene c-fos and c-jun mRNA whose gene expression can be induced by TPA, cyclic AMP and growth factors. |
| S4 | 461-616 | Sentence | denotes | Recent findings suggest an involvement of reactive oxygen species in the pathway of TPA and protein kinase C leading to expression of c-fos and c-jun mRNA. |
| S5 | 617-820 | Sentence | denotes | To investigate the role of reactive oxygen species we studied the effects of alpha-lipoic acid and dihydrolipoic acid (natural thiol antioxidants) on the expression of c-fos mRNA in human Jurkat T cells. |
| S6 | 821-1085 | Sentence | denotes | When cells were preincubated with dihydrolipoic acid (0.2 mM) the expression of c-fos mRNA was suppressed at 30 min after stimulation of TPA (0.5 microM) whereas in the case of preincubation of alpha-lipoic acid (0.2 microM), the expression was enhanced at 30 min. |
| S7 | 1086-1192 | Sentence | denotes | These studies support the idea that superoxide anion radical plays a role in the expression of c-fos mRNA. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 11-28 | other_organic_compound | denotes | alpha-lipoic acid |
| T2 | 33-51 | other_organic_compound | denotes | dihydrolipoic acid |
| T3 | 69-89 | DNA_domain_or_region | denotes | proto-oncogene c-fos |
| T4 | 95-115 | protein_family_or_group | denotes | transcription factor |
| T5 | 116-120 | protein_molecule | denotes | AP-1 |
| T6 | 159-176 | other_name | denotes | cellular response |
| T7 | 180-185 | tissue | denotes | serum |
| T8 | 187-201 | protein_family_or_group | denotes | growth factors |
| T9 | 207-221 | other_organic_compound | denotes | phorbol esters |
| T10 | 230-267 | other_organic_compound | denotes | 12-O-tetradecanoyl-phorbol-13 acetate |
| T11 | 269-272 | other_organic_compound | denotes | TPA |
| T12 | 279-283 | protein_molecule | denotes | AP-1 |
| T13 | 313-333 | protein_complex | denotes | protein heterodimers |
| T14 | 349-369 | DNA_domain_or_region | denotes | proto-oncogene c-fos |
| T15 | 374-384 | RNA_molecule | denotes | c-jun mRNA |
| T16 | 391-406 | other_name | denotes | gene expression |
| T17 | 425-428 | other_organic_compound | denotes | TPA |
| T18 | 430-440 | nucleotide | denotes | cyclic AMP |
| T19 | 445-459 | protein_family_or_group | denotes | growth factors |
| T20 | 503-526 | inorganic | denotes | reactive oxygen species |
| T21 | 545-548 | other_organic_compound | denotes | TPA |
| T22 | 553-569 | protein_molecule | denotes | protein kinase C |
| T23 | 595-600 | other_name | denotes | c-fos |
| T24 | 605-610 | other_name | denotes | c-jun |
| T25 | 611-615 | other_name | denotes | mRNA |
| T26 | 644-667 | inorganic | denotes | reactive oxygen species |
| T27 | 694-711 | other_organic_compound | denotes | alpha-lipoic acid |
| T28 | 716-734 | other_organic_compound | denotes | dihydrolipoic acid |
| T29 | 736-762 | other_organic_compound | denotes | natural thiol antioxidants |
| T30 | 785-795 | RNA_molecule | denotes | c-fos mRNA |
| T31 | 799-819 | cell_line | denotes | human Jurkat T cells |
| T32 | 855-873 | other_organic_compound | denotes | dihydrolipoic acid |
| T33 | 901-906 | DNA_domain_or_region | denotes | c-fos |
| T34 | 958-961 | other_organic_compound | denotes | TPA |
| T35 | 1015-1032 | other_organic_compound | denotes | alpha-lipoic acid |
| T36 | 1122-1146 | inorganic | denotes | superoxide anion radical |
| T37 | 1181-1186 | DNA_domain_or_region | denotes | c-fos |