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PubMed:8144129 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-145 Sentence denotes Detection of minimal residual disease in a patient with acute promyelocytic leukemia by RT-PCR: necessity of chemotherapy following ATRA therapy.
TextSentencer_T2 146-279 Sentence denotes The PML/RAR alpha fusion gene resulting from the t (15;17) translocation is a specific marker for acute promyelocytic leukemia (APL).
TextSentencer_T3 280-530 Sentence denotes We examined bone marrow cells by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect residual PML/RAR alpha mRNA-containing cells following treatment with all-trans retinoic acid (ATRA) and cytotoxic chemotherapy in a patient with APL.
TextSentencer_T4 531-609 Sentence denotes This RT-PCR assay can detect one leukemic cell in 10(2) normal cells in vitro.
TextSentencer_T5 610-775 Sentence denotes We show that PML/RAR alpha mRNA was still detectable despite clinical remission following ATRA treatment, but undetectable following consolidation with chemotherapy.
TextSentencer_T6 776-994 Sentence denotes These data show that this technique is useful for the identification of minimal residual disease in patients with APL and that cytotoxic chemotherapy following ATRA therapy is required for the elimination of APL cells.
T1 0-145 Sentence denotes Detection of minimal residual disease in a patient with acute promyelocytic leukemia by RT-PCR: necessity of chemotherapy following ATRA therapy.
T2 146-279 Sentence denotes The PML/RAR alpha fusion gene resulting from the t (15;17) translocation is a specific marker for acute promyelocytic leukemia (APL).
T3 280-530 Sentence denotes We examined bone marrow cells by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect residual PML/RAR alpha mRNA-containing cells following treatment with all-trans retinoic acid (ATRA) and cytotoxic chemotherapy in a patient with APL.
T4 531-609 Sentence denotes This RT-PCR assay can detect one leukemic cell in 10(2) normal cells in vitro.
T5 610-775 Sentence denotes We show that PML/RAR alpha mRNA was still detectable despite clinical remission following ATRA treatment, but undetectable following consolidation with chemotherapy.
T6 776-994 Sentence denotes These data show that this technique is useful for the identification of minimal residual disease in patients with APL and that cytotoxic chemotherapy following ATRA therapy is required for the elimination of APL cells.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 150-157 gene:84106 denotes PML/RAR
T1 244-277 disease:C0023487 denotes acute promyelocytic leukemia (APL
R1 T0 T1 associated_with PML/RAR,acute promyelocytic leukemia (APL

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 150-175 DNA denotes PML/RAR alpha fusion gene
T2 195-218 DNA denotes t (15;17) translocation
T3 389-424 cell_type denotes PML/RAR alpha mRNA-containing cells
T4 564-577 cell_type denotes leukemic cell
T5 587-599 cell_type denotes normal cells
T6 623-641 RNA denotes PML/RAR alpha mRNA
T7 984-993 cell_type denotes APL cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 56-84 NP denotes acute promyelocytic leukemia
C2 88-94 NP denotes RT-PCR
C3 109-121 NP denotes chemotherapy
C4 132-144 NP denotes ATRA therapy
C5 244-278 NP denotes acute promyelocytic leukemia (APL)
C6 313-369 NP denotes reverse transcriptase-polymerase chain reaction (RT-PCR)
C7 435-480 NP denotes treatment with all-trans retinoic acid (ATRA)
C8 485-507 NP denotes cytotoxic chemotherapy
C9 526-529 NP denotes APL
C10 700-714 NP denotes ATRA treatment
C11 762-774 NP denotes chemotherapy
C12 890-893 NP denotes APL
C13 903-925 NP denotes cytotoxic chemotherapy
C14 936-948 NP denotes ATRA therapy
R1 C5 C1 coref-ident acute promyelocytic leukemia (APL),acute promyelocytic leukemia
R2 C6 C2 coref-ident reverse transcriptase-polymerase chain reaction (RT-PCR),RT-PCR
R3 C9 C5 coref-ident APL,acute promyelocytic leukemia (APL)
R4 C10 C7 coref-ident ATRA treatment,treatment with all-trans retinoic acid (ATRA)
R5 C11 C3 coref-ident chemotherapy,chemotherapy
R6 C12 C9 coref-ident APL,APL
R7 C13 C8 coref-ident cytotoxic chemotherapy,cytotoxic chemotherapy
R8 C14 C4 coref-ident ATRA therapy,ATRA therapy

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-145 Sentence denotes Detection of minimal residual disease in a patient with acute promyelocytic leukemia by RT-PCR: necessity of chemotherapy following ATRA therapy.
S2 146-279 Sentence denotes The PML/RAR alpha fusion gene resulting from the t (15;17) translocation is a specific marker for acute promyelocytic leukemia (APL).
S3 280-530 Sentence denotes We examined bone marrow cells by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect residual PML/RAR alpha mRNA-containing cells following treatment with all-trans retinoic acid (ATRA) and cytotoxic chemotherapy in a patient with APL.
S4 531-609 Sentence denotes This RT-PCR assay can detect one leukemic cell in 10(2) normal cells in vitro.
S5 610-775 Sentence denotes We show that PML/RAR alpha mRNA was still detectable despite clinical remission following ATRA treatment, but undetectable following consolidation with chemotherapy.
S6 776-994 Sentence denotes These data show that this technique is useful for the identification of minimal residual disease in patients with APL and that cytotoxic chemotherapy following ATRA therapy is required for the elimination of APL cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T3 56-84 other_name denotes acute promyelocytic leukemia
T4 88-94 other_name denotes RT-PCR
T5 109-121 other_name denotes chemotherapy
T6 132-144 other_name denotes ATRA therapy
T7 150-175 DNA_domain_or_region denotes PML/RAR alpha fusion gene
T8 195-218 DNA_domain_or_region denotes t (15;17) translocation
T9 244-272 other_name denotes acute promyelocytic leukemia
T10 274-277 other_name denotes APL
T11 362-368 other_name denotes RT-PCR
T12 389-407 RNA_molecule denotes PML/RAR alpha mRNA
T13 450-473 other_organic_compound denotes all-trans retinoic acid
T14 475-479 other_organic_compound denotes ATRA
T15 485-494 other_name denotes cytotoxic
T16 495-507 other_name denotes chemotherapy
T17 513-520 multi_cell denotes patient
T18 526-529 other_name denotes APL
T19 536-542 other_name denotes RT-PCR
T20 564-577 cell_type denotes leukemic cell
T21 587-599 cell_type denotes normal cells
T22 623-641 RNA_molecule denotes PML/RAR alpha mRNA
T23 700-704 other_organic_compound denotes ATRA
T24 762-774 other_name denotes chemotherapy
T25 848-872 other_name denotes minimal residual disease
T1 13-37 other_name denotes minimal residual disease
T2 43-50 multi_cell denotes patient
T26 876-884 multi_cell denotes patients
T27 890-893 other_name denotes APL
T28 903-912 other_name denotes cytotoxic
T29 913-925 other_name denotes chemotherapy
T30 936-940 other_organic_compound denotes ATRA
T31 984-987 other_name denotes APL

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 56-84 HP:0004836 denotes acute promyelocytic leukemia
AB1 244-272 HP:0004836 denotes acute promyelocytic leukemia

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 56-84 ORDO:520 denotes acute promyelocytic leukemia
AB1 244-272 ORDO:520 denotes acute promyelocytic leukemia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 292-303 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 292-303 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow