PubMed:8137421 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8137421","sourcedb":"PubMed","sourceid":"8137421","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8137421","text":"JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.\nThe ultraviolet (UV) response of mammalian cells is characterized by a rapid and selective increase in gene expression mediated by AP-1 and NF-kappa B. The effect on AP-1 transcriptional activity results, in part, from enhanced phosphorylation of the c-Jun NH2-terminal activation domain. Here, we describe the molecular cloning and characterization of JNK1, a distant relative of the MAP kinase group that is activated by dual phosphorylation at Thr and Tyr during the UV response. Significantly, Ha-Ras partially activates JNK1 and potentiates the activation caused by UV. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Thus, JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation. These properties indicate that JNK1 activation may play an important role in tumor promotion.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein"},{"id":"T2","span":{"begin":50,"end":56},"obj":"protein"},{"id":"T3","span":{"begin":91,"end":96},"obj":"protein"},{"id":"T4","span":{"begin":247,"end":251},"obj":"protein"},{"id":"T5","span":{"begin":256,"end":266},"obj":"protein"},{"id":"T6","span":{"begin":282,"end":286},"obj":"protein"},{"id":"T7","span":{"begin":367,"end":372},"obj":"protein"},{"id":"T8","span":{"begin":469,"end":473},"obj":"protein"},{"id":"T9","span":{"begin":501,"end":511},"obj":"protein"},{"id":"T10","span":{"begin":614,"end":620},"obj":"protein"},{"id":"T11","span":{"begin":641,"end":645},"obj":"protein"},{"id":"T12","span":{"begin":691,"end":695},"obj":"protein"},{"id":"T13","span":{"begin":709,"end":714},"obj":"protein"},{"id":"T14","span":{"begin":788,"end":792},"obj":"protein"},{"id":"T15","span":{"begin":932,"end":936},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"},{"subj":"T7","pred":"source","obj":"AIMed"},{"subj":"T8","pred":"source","obj":"AIMed"},{"subj":"T9","pred":"source","obj":"AIMed"},{"subj":"T10","pred":"source","obj":"AIMed"},{"subj":"T11","pred":"source","obj":"AIMed"},{"subj":"T12","pred":"source","obj":"AIMed"},{"subj":"T13","pred":"source","obj":"AIMed"},{"subj":"T14","pred":"source","obj":"AIMed"},{"subj":"T15","pred":"source","obj":"AIMed"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":978,"end":983},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"subj":"T1","pred":"source","obj":"mondo_disease"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":978,"end":983},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"subj":"T1","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#c7ec93","default":true},{"id":"mondo_disease","color":"#ec93e1"},{"id":"HP-phenotype","color":"#93ecdd"}]}]}}