PubMed:8137243
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 33-55 | protein | denotes | nuclear factor kappa B |
| T2 | 87-102 | protein | denotes | I kappa B alpha |
| T3 | 141-156 | cell_type | denotes | mammalian cells |
| T4 | 184-219 | protein | denotes | transcriptional regulatory proteins |
| T5 | 228-250 | protein | denotes | nuclear factor kappa B |
| T6 | 252-262 | protein | denotes | NF-kappa B |
| T7 | 292-312 | DNA | denotes | early response genes |
| T8 | 394-409 | protein | denotes | I kappa B alpha |
| T9 | 433-443 | protein | denotes | NF-kappa B |
| T10 | 491-514 | DNA | denotes | reporter gene construct |
| T11 | 530-558 | DNA | denotes | NF-kappa B DNA binding sites |
| T12 | 595-610 | protein | denotes | tyrosine kinase |
| T13 | 630-654 | DNA | denotes | dominant negative allele |
| T14 | 658-665 | DNA | denotes | c-Raf-1 |
| T15 | 667-674 | protein | denotes | Raf 301 |
| T16 | 686-701 | protein | denotes | I kappa B alpha |
| T17 | 715-725 | protein | denotes | NF-kappa B |
| T18 | 758-785 | DNA | denotes | kappa B reporter constructs |
| T19 | 877-892 | protein | denotes | I kappa B alpha |
| T20 | 898-908 | protein | denotes | NF-kappa B |
| T21 | 943-958 | protein | denotes | I kappa B alpha |
| T22 | 1147-1162 | protein | denotes | I kappa B alpha |
| T23 | 1173-1188 | protein | denotes | I kappa B alpha |
| T24 | 1205-1215 | protein | denotes | NF-kappa B |
| T25 | 1262-1272 | protein | denotes | NF-kappa B |
| T26 | 1310-1331 | protein | denotes | tumor necrosis factor |
| T27 | 1401-1416 | protein | denotes | I kappa B alpha |
| T28 | 1521-1536 | protein | denotes | I kappa B alpha |
| T29 | 1635-1645 | protein | denotes | NF-kappa B |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-7 | NP | denotes | Hypoxia |
| C2 | 15-55 | NP | denotes | the activation of nuclear factor kappa B |
| C3 | 87-102 | NP | denotes | I kappa B alpha |
| C4 | 228-263 | NP | denotes | nuclear factor kappa B (NF-kappa B) |
| C5 | 364-382 | NP | denotes | hypoxia (0.02% O2) |
| C6 | 394-421 | NP | denotes | I kappa B alpha degradation |
| C7 | 470-514 | NP | denotes | transactivation of a reporter gene construct |
| C8 | 686-713 | NP | denotes | I kappa B alpha degradation |
| C9 | 715-733 | NP | denotes | NF-kappa B binding |
| C10 | 739-785 | NP | denotes | transactivation of kappa B reporter constructs |
| C11 | 789-796 | NP | denotes | hypoxia |
| C12 | 877-892 | NP | denotes | I kappa B alpha |
| C13 | 898-919 | NP | denotes | NF-kappa B activation |
| C14 | 943-958 | NP | denotes | I kappa B alpha |
| C15 | 982-998 | NP | denotes | hypoxic exposure |
| C17 | 1014-1017 | NP | denotes | its |
| C16 | 1014-1049 | NP | denotes | its tyrosine phosphorylation status |
| C18 | 1067-1083 | NP | denotes | hypoxic exposure |
| C19 | 1147-1162 | NP | denotes | I kappa B alpha |
| C20 | 1173-1200 | NP | denotes | I kappa B alpha degradation |
| C21 | 1205-1223 | NP | denotes | NF-kappa B binding |
| C22 | 1262-1272 | NP | denotes | NF-kappa B |
| C24 | 1401-1416 | NP | denotes | I kappa B alpha |
| C23 | 1362-1416 | NP | denotes | the tyrosine phosphorylation status of I kappa B alpha |
| C25 | 1521-1536 | NP | denotes | I kappa B alpha |
| C26 | 1544-1551 | NP | denotes | hypoxia |
| C27 | 1555-1581 | NP | denotes | an important proximal step |
| C28 | 1582-1587 | NP | denotes | which |
| C29 | 1597-1600 | NP | denotes | its |
| C30 | 1635-1645 | NP | denotes | NF-kappa B |
| R1 | C5 | C1 | coref-ident | hypoxia (0.02% O2),Hypoxia |
| R2 | C8 | C6 | coref-ident | I kappa B alpha degradation,I kappa B alpha degradation |
| R3 | C10 | C7 | coref-ident | transactivation of kappa B reporter constructs,transactivation of a reporter gene construct |
| R4 | C11 | C5 | coref-ident | hypoxia,hypoxia (0.02% O2) |
| R5 | C12 | C3 | coref-ident | I kappa B alpha,I kappa B alpha |
| R6 | C13 | C2 | coref-ident | NF-kappa B activation,the activation of nuclear factor kappa B |
| R7 | C14 | C12 | coref-ident | I kappa B alpha,I kappa B alpha |
| R8 | C16 | C14 | coref-pron | its tyrosine phosphorylation status,I kappa B alpha |
| R9 | C18 | C15 | coref-ident | hypoxic exposure,hypoxic exposure |
| R10 | C19 | C14 | coref-ident | I kappa B alpha,I kappa B alpha |
| R11 | C20 | C8 | coref-ident | I kappa B alpha degradation,I kappa B alpha degradation |
| R12 | C21 | C9 | coref-ident | NF-kappa B binding,NF-kappa B binding |
| R13 | C22 | C4 | coref-ident | NF-kappa B,nuclear factor kappa B (NF-kappa B) |
| R14 | C24 | C19 | coref-ident | I kappa B alpha,I kappa B alpha |
| R15 | C23 | C17 | coref-ident | the tyrosine phosphorylation status of I kappa B alpha,its |
| R16 | C25 | C24 | coref-ident | I kappa B alpha,I kappa B alpha |
| R17 | C26 | C11 | coref-ident | hypoxia,hypoxia |
| R18 | C28 | C27 | coref-ident | which,an important proximal step |
| R19 | C29 | C25 | coref-pron | its,I kappa B alpha |
| R20 | C30 | C22 | coref-ident | NF-kappa B,NF-kappa B |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-124 | Sentence | denotes | Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. |
| S2 | 125-313 | Sentence | denotes | The response of mammalian cells to stress is controlled by transcriptional regulatory proteins such as nuclear factor kappa B (NF-kappa B) to induce a wide variety of early response genes. |
| S3 | 314-559 | Sentence | denotes | In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites. |
| S4 | 560-797 | Sentence | denotes | Pretreatment of cells with protein tyrosine kinase inhibitors and the dominant negative allele of c-Raf-1 (Raf 301) inhibited I kappa B alpha degradation, NF-kappa B binding, and transactivation of kappa B reporter constructs by hypoxia. |
| S5 | 798-1084 | Sentence | denotes | To demonstrate a direct link between changes in the phosphorylation pattern of I kappa B alpha with NF-kappa B activation, we immunoprecipitated I kappa B alpha after varying times of hypoxic exposure and found that its tyrosine phosphorylation status increased during hypoxic exposure. |
| S6 | 1085-1224 | Sentence | denotes | Inhibition of the transfer of tyrosine phosphoryl groups onto I kappa B alpha prevented I kappa B alpha degradation and NF-kappa B binding. |
| S7 | 1225-1465 | Sentence | denotes | In comparison to other activators of NF-kappa B such as phorbol myristate acetate or tumor necrosis factor, we did not detect changes in the tyrosine phosphorylation status of I kappa B alpha following treatment with either of these agents. |
| S8 | 1466-1646 | Sentence | denotes | These results suggest that tyrosine phosphorylation of I kappa B alpha during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-kappa B. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-7 | other_name | denotes | Hypoxia |
| T2 | 33-55 | protein_molecule | denotes | nuclear factor kappa B |
| T3 | 87-102 | protein_molecule | denotes | I kappa B alpha |
| T4 | 106-114 | amino_acid_monomer | denotes | tyrosine |
| T5 | 141-156 | cell_type | denotes | mammalian cells |
| T6 | 184-219 | protein_family_or_group | denotes | transcriptional regulatory proteins |
| T7 | 228-250 | protein_molecule | denotes | nuclear factor kappa B |
| T8 | 252-262 | protein_molecule | denotes | NF-kappa B |
| T9 | 292-312 | DNA_family_or_group | denotes | early response genes |
| T10 | 364-371 | other_name | denotes | hypoxia |
| T11 | 394-409 | protein_molecule | denotes | I kappa B alpha |
| T12 | 433-443 | protein_molecule | denotes | NF-kappa B |
| T13 | 491-514 | DNA_molecule | denotes | reporter gene construct |
| T14 | 530-540 | protein_molecule | denotes | NF-kappa B |
| T15 | 587-594 | other_organic_compound | denotes | protein |
| T16 | 595-603 | amino_acid_monomer | denotes | tyrosine |
| T17 | 630-654 | DNA_domain_or_region | denotes | dominant negative allele |
| T18 | 658-665 | DNA_domain_or_region | denotes | c-Raf-1 |
| T19 | 667-674 | protein_molecule | denotes | Raf 301 |
| T20 | 686-701 | protein_molecule | denotes | I kappa B alpha |
| T21 | 715-725 | protein_molecule | denotes | NF-kappa B |
| T22 | 758-785 | DNA_molecule | denotes | kappa B reporter constructs |
| T23 | 789-796 | other_name | denotes | hypoxia |
| T24 | 877-892 | protein_molecule | denotes | I kappa B alpha |
| T25 | 898-908 | protein_molecule | denotes | NF-kappa B |
| T26 | 943-958 | protein_molecule | denotes | I kappa B alpha |
| T27 | 982-998 | other_name | denotes | hypoxic exposure |
| T28 | 1018-1026 | amino_acid_monomer | denotes | tyrosine |
| T29 | 1067-1083 | other_name | denotes | hypoxic exposure |
| T30 | 1115-1123 | amino_acid_monomer | denotes | tyrosine |
| T31 | 1147-1162 | protein_molecule | denotes | I kappa B alpha |
| T32 | 1173-1188 | protein_molecule | denotes | I kappa B alpha |
| T33 | 1205-1215 | protein_molecule | denotes | NF-kappa B |
| T34 | 1262-1272 | protein_molecule | denotes | NF-kappa B |
| T35 | 1281-1306 | other_organic_compound | denotes | phorbol myristate acetate |
| T36 | 1310-1331 | protein_family_or_group | denotes | tumor necrosis factor |
| T37 | 1366-1374 | amino_acid_monomer | denotes | tyrosine |
| T38 | 1401-1416 | protein_molecule | denotes | I kappa B alpha |
| T39 | 1493-1501 | amino_acid_monomer | denotes | tyrosine |
| T40 | 1521-1536 | protein_molecule | denotes | I kappa B alpha |
| T41 | 1544-1551 | other_name | denotes | hypoxia |
| T42 | 1635-1645 | protein_molecule | denotes | NF-kappa B |