PubMed:8128231 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8128231","sourcedb":"PubMed","sourceid":"8128231","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8128231","text":"Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.\nThe gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":32,"end":51},"obj":"protein"},{"id":"T2","span":{"begin":61,"end":74},"obj":"protein"},{"id":"T3","span":{"begin":109,"end":138},"obj":"protein"},{"id":"T4","span":{"begin":169,"end":182},"obj":"protein"},{"id":"T5","span":{"begin":363,"end":367},"obj":"protein"},{"id":"T6","span":{"begin":485,"end":489},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#93ecd6","default":true}]}]}}