| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-126 |
Sentence |
denotes |
Influence of cholesterol feeding on liver microsomal metabolism of steroids and bile acids in conventional and germ-free rats. |
| T2 |
127-295 |
Sentence |
denotes |
The present investigation has aimed at defining the factor responsible for the differences in microsomal metabolism of steroids between germ-free and conventional rats. |
| T3 |
296-649 |
Sentence |
denotes |
Cholesterol, cholic acid, taurocholic acid, and chenodeoxycholic acid were fed to conventional and germ-free male rats and the effects on liver microsomal metabolism of 4-[4-14C]androstene-3,17-dione, 5alpha-[4-14C]androstane-3alpha,17beta-diol, [4-14C]-cholesterol, 7alpha-hydroxy-4-[6beta-3H]cholesten-3-one, and [24-14C]lithocholic acid were studied. |
| T4 |
650-1100 |
Sentence |
denotes |
The most consistent effects were found with dietary cholesterol that stimulated the activities of several of the hydroxylases active on 4-androstene-3,17-dione and 5alpha-androstane-3alpha,17beta-diol and that decreased the 5alpha reduction of 4-androstene-3,17-dione, increased the 7alpha hydroxylation of cholesterol, decreased the 12alpha hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, and increased by 6beta hydroxylation of lithocholic acid. |
| T5 |
1101-1296 |
Sentence |
denotes |
These effects of cholesterol feeding on the microsomal metabolism of steroids in conventional rats made the pattern of microsomal enzyme activities resemble that characteristic of germ-free rats. |
| T6 |
1297-1423 |
Sentence |
denotes |
Cholesterol feeding led to a pronounced increase in the intestinal concentration of beta-muricholic acid in conventional rats. |
| T7 |
1424-1713 |
Sentence |
denotes |
Furthermore, cholesterol feeding to conventional animals led to an intestinal ratio of chenodeoxycholic acid (including its metabolites alpha- and beta-muricholic acid and hyodeoxycholic acid) to cholic acid (including deoxycholic acid) that was almost identical to that in germ-free rats. |
| T8 |
1714-2010 |
Sentence |
denotes |
Conventionalization of germ-free rats for a period of up to 56 days led only to a partial normalization of the liver microsomal metabolism of 5alpha-[4-14C]androstane-3alpha, 17beta-diol and 7alpha-hydroxy-4-[6beta-3H]cholesten-3-one and of the liver microsomal concentration of cytochrome P-450. |
| T9 |
2011-2192 |
Sentence |
denotes |
The concentration of cholesterol was higher in both total liver homogenate and liver microsomal fraction of germ-free rats than in corresponding preparations from conventional rats. |
| T10 |
2193-2362 |
Sentence |
denotes |
In conclusion, it is suggested that cholesterol is one of the factors responsible for the different microsomal metabolism of steroids in germ-free and conventional rats. |
| T11 |
2363-2462 |
Sentence |
denotes |
It is also suggested that cholesterol may play a role as regulator of microsomal enzyme activities. |
| T1 |
0-126 |
Sentence |
denotes |
Influence of cholesterol feeding on liver microsomal metabolism of steroids and bile acids in conventional and germ-free rats. |
| T2 |
127-295 |
Sentence |
denotes |
The present investigation has aimed at defining the factor responsible for the differences in microsomal metabolism of steroids between germ-free and conventional rats. |
| T3 |
296-649 |
Sentence |
denotes |
Cholesterol, cholic acid, taurocholic acid, and chenodeoxycholic acid were fed to conventional and germ-free male rats and the effects on liver microsomal metabolism of 4-[4-14C]androstene-3,17-dione, 5alpha-[4-14C]androstane-3alpha,17beta-diol, [4-14C]-cholesterol, 7alpha-hydroxy-4-[6beta-3H]cholesten-3-one, and [24-14C]lithocholic acid were studied. |
| T4 |
650-1100 |
Sentence |
denotes |
The most consistent effects were found with dietary cholesterol that stimulated the activities of several of the hydroxylases active on 4-androstene-3,17-dione and 5alpha-androstane-3alpha,17beta-diol and that decreased the 5alpha reduction of 4-androstene-3,17-dione, increased the 7alpha hydroxylation of cholesterol, decreased the 12alpha hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, and increased by 6beta hydroxylation of lithocholic acid. |
| T5 |
1101-1296 |
Sentence |
denotes |
These effects of cholesterol feeding on the microsomal metabolism of steroids in conventional rats made the pattern of microsomal enzyme activities resemble that characteristic of germ-free rats. |
| T6 |
1297-1423 |
Sentence |
denotes |
Cholesterol feeding led to a pronounced increase in the intestinal concentration of beta-muricholic acid in conventional rats. |
| T7 |
1424-1713 |
Sentence |
denotes |
Furthermore, cholesterol feeding to conventional animals led to an intestinal ratio of chenodeoxycholic acid (including its metabolites alpha- and beta-muricholic acid and hyodeoxycholic acid) to cholic acid (including deoxycholic acid) that was almost identical to that in germ-free rats. |
| T8 |
1714-2010 |
Sentence |
denotes |
Conventionalization of germ-free rats for a period of up to 56 days led only to a partial normalization of the liver microsomal metabolism of 5alpha-[4-14C]androstane-3alpha, 17beta-diol and 7alpha-hydroxy-4-[6beta-3H]cholesten-3-one and of the liver microsomal concentration of cytochrome P-450. |
| T9 |
2011-2192 |
Sentence |
denotes |
The concentration of cholesterol was higher in both total liver homogenate and liver microsomal fraction of germ-free rats than in corresponding preparations from conventional rats. |
| T10 |
2193-2362 |
Sentence |
denotes |
In conclusion, it is suggested that cholesterol is one of the factors responsible for the different microsomal metabolism of steroids in germ-free and conventional rats. |
| T11 |
2363-2462 |
Sentence |
denotes |
It is also suggested that cholesterol may play a role as regulator of microsomal enzyme activities. |
