PubMed:8108414
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 22-47 | protein | denotes | NF-kappa B transactivator |
| T2 | 48-52 | protein | denotes | RelA |
| T3 | 54-57 | protein | denotes | p65 |
| T4 | 71-93 | protein | denotes | cytoplasmic inhibitors |
| T5 | 105-119 | protein | denotes | ankyrin motifs |
| T6 | 121-125 | protein | denotes | RelA |
| T7 | 127-130 | protein | denotes | p65 |
| T8 | 191-231 | protein | denotes | heterodimeric p50-p65 NF-kappa B complex |
| T9 | 247-273 | protein | denotes | high-affinity binding site |
| T10 | 282-303 | protein | denotes | cytoplasmic inhibitor |
| T11 | 305-320 | protein | denotes | I kappa B alpha |
| T12 | 349-364 | protein | denotes | I kappa B alpha |
| T13 | 438-448 | protein | denotes | NF-kappa B |
| T14 | 486-513 | protein | denotes | tumor necrosis factor alpha |
| T15 | 537-552 | protein | denotes | I kappa B alpha |
| T16 | 556-569 | cell_type | denotes | human T cells |
| T17 | 646-661 | protein | denotes | I kappa B alpha |
| T18 | 746-750 | protein | denotes | RelA |
| T19 | 794-810 | protein | denotes | cytoplasmic RelA |
| T20 | 846-861 | protein | denotes | I kappa B alpha |
| T21 | 882-909 | protein | denotes | ankyrin motif-rich proteins |
| T22 | 940-987 | DNA | denotes | NF-kappa B2 (p100) and NF-kappa B1 (p105) genes |
| T23 | 1009-1013 | protein | denotes | RelA |
| T24 | 1013-1029 | protein | denotes | -I kappa B alpha |
| T25 | 1031-1062 | protein | denotes | RelA-p100 cytoplasmic complexes |
| T26 | 1093-1120 | protein | denotes | tumor necrosis factor alpha |
| T27 | 1139-1143 | protein | denotes | p100 |
| T28 | 1179-1183 | protein | denotes | RelA |
| T29 | 1240-1244 | protein | denotes | RelA |
| T30 | 1249-1253 | protein | denotes | p100 |
| T31 | 1267-1296 | protein | denotes | conserved Rel homology domain |
| T32 | 1326-1353 | protein | denotes | nuclear localization signal |
| T33 | 1357-1361 | protein | denotes | RelA |
| T34 | 1385-1400 | protein | denotes | I kappa B alpha |
| T35 | 1414-1418 | protein | denotes | p100 |
| T36 | 1433-1437 | protein | denotes | RelA |
| T37 | 1460-1491 | protein | denotes | C-terminal ankyrin motif domain |
| T38 | 1533-1537 | protein | denotes | RelA |
| T39 | 1565-1580 | protein | denotes | I kappa B alpha |
| T40 | 1590-1594 | protein | denotes | RelA |
| T41 | 1606-1615 | RNA | denotes | p100 mRNA |
| T42 | 1787-1805 | protein | denotes | nuclear NF-kappa B |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-120 | Sentence | denotes | Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. |
| S2 | 121-321 | Sentence | denotes | RelA (p65) functions as the critical transactivating component of the heterodimeric p50-p65 NF-kappa B complex and contains a high-affinity binding site for its cytoplasmic inhibitor, I kappa B alpha. |
| S3 | 322-449 | Sentence | denotes | After cellular activation, I kappa B alpha is rapidly degraded in concert with the induced nuclear translocation of NF-kappa B. |
| S4 | 450-619 | Sentence | denotes | The present study demonstrates that tumor necrosis factor alpha-induced degradation of I kappa B alpha in human T cells is preceded by its rapid phosphorylation in vivo. |
| S5 | 620-751 | Sentence | denotes | However, these effects on I kappa B alpha result in nuclear mobilization of only a fraction of the entire cytoplasmic pool of RelA. |
| S6 | 752-1639 | Sentence | denotes | Subsequent studies have revealed that (i) cytoplasmic RelA is stably associated not only with I kappa B alpha but also with other ankyrin motif-rich proteins including the products of the NF-kappa B2 (p100) and NF-kappa B1 (p105) genes; (ii) in contrast to RelA-I kappa B alpha, RelA-p100 cytoplasmic complexes are not dissociated following tumor necrosis factor alpha activation; (iii) p100 functions as a potent inhibitor of RelA-mediated transcription in vivo; (iv) the interaction of RelA and p100 involves the conserved Rel homology domain of both proteins but not the nuclear localization signal of RelA, which is required for I kappa B alpha binding; (v) p100 inhibition of RelA function requires the C-terminal ankyrin motif domain, which mediates cytoplasmic retention of RelA; and (vi) as observed with I kappa B alpha, nuclear RelA stimulates p100 mRNA and protein expression. |
| S7 | 1640-1806 | Sentence | denotes | These findings thus reveal the presence of a second inducible autoregulated inhibitory pathway that helps ensure the rapid but transient action of nuclear NF-kappa B. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 18-58 | NP | denotes | the NF-kappa B transactivator RelA (p65) |
| C2 | 121-131 | NP | denotes | RelA (p65) |
| C3 | 187-231 | NP | denotes | the heterodimeric p50-p65 NF-kappa B complex |
| C5 | 278-281 | NP | denotes | its |
| C4 | 278-303 | NP | denotes | its cytoplasmic inhibitor |
| C6 | 305-320 | NP | denotes | I kappa B alpha |
| C7 | 349-364 | NP | denotes | I kappa B alpha |
| C8 | 537-569 | NP | denotes | I kappa B alpha in human T cells |
| C9 | 585-588 | NP | denotes | its |
| C10 | 646-661 | NP | denotes | I kappa B alpha |
| C11 | 746-750 | NP | denotes | RelA |
| C12 | 846-861 | NP | denotes | I kappa B alpha |
| C13 | 936-958 | NP | denotes | the NF-kappa B2 (p100) |
| C14 | 1009-1014 | NP | denotes | RelA- |
| C15 | 1031-1036 | NP | denotes | RelA- |
| C16 | 1139-1143 | NP | denotes | p100 |
| C17 | 1179-1184 | NP | denotes | RelA- |
| C18 | 1240-1244 | NP | denotes | RelA |
| C19 | 1249-1253 | NP | denotes | p100 |
| C20 | 1357-1361 | NP | denotes | RelA |
| C21 | 1363-1368 | NP | denotes | which |
| C22 | 1433-1437 | NP | denotes | RelA |
| C23 | 1456-1491 | NP | denotes | the C-terminal ankyrin motif domain |
| C24 | 1493-1498 | NP | denotes | which |
| C25 | 1533-1538 | NP | denotes | RelA; |
| C26 | 1565-1580 | NP | denotes | I kappa B alpha |
| C27 | 1683-1734 | NP | denotes | a second inducible autoregulated inhibitory pathway |
| C28 | 1735-1739 | NP | denotes | that |
| R1 | C2 | C1 | coref-ident | RelA (p65),the NF-kappa B transactivator RelA (p65) |
| R2 | C4 | C3 | coref-pron | its cytoplasmic inhibitor,the heterodimeric p50-p65 NF-kappa B complex |
| R3 | C7 | C6 | coref-ident | I kappa B alpha,I kappa B alpha |
| R4 | C8 | C7 | coref-ident | I kappa B alpha in human T cells,I kappa B alpha |
| R5 | C9 | C8 | coref-pron | its,I kappa B alpha in human T cells |
| R6 | C10 | C8 | coref-ident | I kappa B alpha,I kappa B alpha in human T cells |
| R7 | C11 | C2 | coref-other | RelA,RelA (p65) |
| R8 | C12 | C10 | coref-ident | I kappa B alpha,I kappa B alpha |
| R9 | C14 | C11 | coref-ident | RelA-,RelA |
| R10 | C15 | C14 | coref-ident | RelA-,RelA- |
| R11 | C16 | C13 | coref-ident | p100,the NF-kappa B2 (p100) |
| R12 | C17 | C15 | coref-ident | RelA-,RelA- |
| R13 | C18 | C17 | coref-ident | RelA,RelA- |
| R14 | C19 | C16 | coref-ident | p100,p100 |
| R15 | C20 | C18 | coref-ident | RelA,RelA |
| R16 | C21 | C20 | coref-relat | which,RelA |
| R17 | C22 | C20 | coref-ident | RelA,RelA |
| R18 | C24 | C23 | coref-relat | which,the C-terminal ankyrin motif domain |
| R19 | C25 | C22 | coref-ident | RelA;,RelA |
| R20 | C26 | C12 | coref-ident | I kappa B alpha,I kappa B alpha |
| R21 | C28 | C27 | coref-relat | that,a second inducible autoregulated inhibitory pathway |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 22-32 | protein_complex | denotes | NF-kappa B |
| T2 | 48-52 | protein_subunit | denotes | RelA |
| T3 | 54-57 | protein_subunit | denotes | p65 |
| T4 | 71-93 | protein_family_or_group | denotes | cytoplasmic inhibitors |
| T5 | 121-125 | protein_subunit | denotes | RelA |
| T6 | 127-130 | protein_subunit | denotes | p65 |
| T7 | 191-209 | protein_complex | denotes | heterodimeric p50- |
| T8 | 209-212 | protein_subunit | denotes | p65 |
| T9 | 213-223 | protein_complex | denotes | NF-kappa B |
| T10 | 247-273 | protein_domain_or_region | denotes | high-affinity binding site |
| T11 | 282-303 | protein_family_or_group | denotes | cytoplasmic inhibitor |
| T12 | 305-320 | protein_molecule | denotes | I kappa B alpha |
| T13 | 349-364 | protein_molecule | denotes | I kappa B alpha |
| T14 | 438-448 | protein_complex | denotes | NF-kappa B |
| T15 | 486-513 | protein_molecule | denotes | tumor necrosis factor alpha |
| T16 | 537-552 | protein_molecule | denotes | I kappa B alpha |
| T17 | 556-569 | cell_type | denotes | human T cells |
| T18 | 646-661 | protein_molecule | denotes | I kappa B alpha |
| T19 | 726-742 | other_name | denotes | cytoplasmic pool |
| T20 | 746-750 | protein_subunit | denotes | RelA |
| T21 | 794-805 | protein_subunit | denotes | cytoplasmic |
| T22 | 806-810 | protein_subunit | denotes | RelA |
| T23 | 846-861 | protein_molecule | denotes | I kappa B alpha |
| T24 | 882-909 | protein_family_or_group | denotes | ankyrin motif-rich proteins |
| T25 | 1009-1013 | protein_subunit | denotes | RelA |
| T26 | 1013-1029 | protein_molecule | denotes | -I kappa B alpha |
| T27 | 1031-1035 | protein_subunit | denotes | RelA |
| T28 | 1093-1120 | protein_molecule | denotes | tumor necrosis factor alpha |
| T29 | 1139-1143 | protein_molecule | denotes | p100 |
| T30 | 1179-1183 | protein_subunit | denotes | RelA |
| T31 | 1240-1244 | protein_subunit | denotes | RelA |
| T32 | 1249-1253 | protein_molecule | denotes | p100 |
| T33 | 1267-1296 | protein_domain_or_region | denotes | conserved Rel homology domain |
| T34 | 1326-1353 | protein_domain_or_region | denotes | nuclear localization signal |
| T35 | 1357-1361 | protein_subunit | denotes | RelA |
| T36 | 1385-1400 | protein_molecule | denotes | I kappa B alpha |
| T37 | 1414-1418 | protein_molecule | denotes | p100 |
| T38 | 1433-1437 | protein_subunit | denotes | RelA |
| T39 | 1460-1491 | protein_domain_or_region | denotes | C-terminal ankyrin motif domain |
| T40 | 1533-1537 | protein_subunit | denotes | RelA |
| T41 | 1565-1580 | protein_molecule | denotes | I kappa B alpha |
| T42 | 1590-1594 | protein_subunit | denotes | RelA |
| T43 | 1606-1610 | protein_molecule | denotes | p100 |
| T44 | 1620-1638 | other_name | denotes | protein expression |
| T45 | 1692-1734 | other_name | denotes | inducible autoregulated inhibitory pathway |
| T46 | 1787-1794 | protein_complex | denotes | nuclear |
| T47 | 1795-1805 | protein_complex | denotes | NF-kappa B |