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PubMed:8099583 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes Purification and characterization of eukaryotic initiation factor (eIF)-2 alpha kinases from Ehrlich ascites tumor cells.
T2 122-296 Sentence denotes A major mechanism of regulation of mammalian protein synthesis initiation is accomplished by the phosphorylation of the alpha subunit of eukaryotic initiation factor (eIF) 2.
T3 297-542 Sentence denotes This modification inhibits the activity of another initiation factor, guanine nucleotide exchange factor, preventing conversion of eIF-2.GDP to eIF-2.GTP and hence binding of initiator tRNA and formation of ternary complex (eIF-2.GTP.Met-tRNAf).
T4 543-749 Sentence denotes Inhibition of protein synthesis and phosphorylation of eIF-2 occurs in Ehrlich cells when they are amino acid- or serum-deprived or heat-shocked as well as in other nucleated cells under similar conditions.
T5 750-834 Sentence denotes This paper describes the purification of two eIF-2 alpha kinases from Ehrlich cells.
T6 835-1082 Sentence denotes Unlike the two well characterized eIF-2 alpha kinases, HRI (heme-regulated inhibitor from reticulocytes) and P68 (double-stranded RNA-dependent kinase found in interferon-treated cells), the Ehrlich cell kinases do not appear to autophosphorylate.
T7 1083-1154 Sentence denotes The two kinases chromatograph differently on DEAE-cellulose and Mono Q.
T8 1155-1228 Sentence denotes Furthermore, their Michaelis constants (Km values) for ATP are different.
T9 1229-1347 Sentence denotes Both kinases can inhibit purified guanine nucleotide exchange factor (GEF) from stimulating ternary complex formation.
T10 1348-1430 Sentence denotes However, only one kinase inhibits reticulocyte lysate cell free protein synthesis.
T11 1431-1569 Sentence denotes The other kinase co-purifies with a factor that suppresses inhibition of protein synthesis in reticulocyte lysates by eIF-2 alpha kinases.
T12 1570-1643 Sentence denotes This suppressing activity is probably guanine nucleotide exchange factor.
T1 0-121 Sentence denotes Purification and characterization of eukaryotic initiation factor (eIF)-2 alpha kinases from Ehrlich ascites tumor cells.
T2 122-296 Sentence denotes A major mechanism of regulation of mammalian protein synthesis initiation is accomplished by the phosphorylation of the alpha subunit of eukaryotic initiation factor (eIF) 2.
T3 297-542 Sentence denotes This modification inhibits the activity of another initiation factor, guanine nucleotide exchange factor, preventing conversion of eIF-2.GDP to eIF-2.GTP and hence binding of initiator tRNA and formation of ternary complex (eIF-2.GTP.Met-tRNAf).
T4 543-749 Sentence denotes Inhibition of protein synthesis and phosphorylation of eIF-2 occurs in Ehrlich cells when they are amino acid- or serum-deprived or heat-shocked as well as in other nucleated cells under similar conditions.
T5 750-834 Sentence denotes This paper describes the purification of two eIF-2 alpha kinases from Ehrlich cells.
T6 835-1082 Sentence denotes Unlike the two well characterized eIF-2 alpha kinases, HRI (heme-regulated inhibitor from reticulocytes) and P68 (double-stranded RNA-dependent kinase found in interferon-treated cells), the Ehrlich cell kinases do not appear to autophosphorylate.
T7 1083-1154 Sentence denotes The two kinases chromatograph differently on DEAE-cellulose and Mono Q.
T8 1155-1228 Sentence denotes Furthermore, their Michaelis constants (Km values) for ATP are different.
T9 1229-1347 Sentence denotes Both kinases can inhibit purified guanine nucleotide exchange factor (GEF) from stimulating ternary complex formation.
T10 1348-1430 Sentence denotes However, only one kinase inhibits reticulocyte lysate cell free protein synthesis.
T11 1431-1569 Sentence denotes The other kinase co-purifies with a factor that suppresses inhibition of protein synthesis in reticulocyte lysates by eIF-2 alpha kinases.
T12 1570-1643 Sentence denotes This suppressing activity is probably guanine nucleotide exchange factor.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 109-114 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 101-108 Phenotype denotes ascites HP:0001541
T2 109-114 Phenotype denotes tumor HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 101-108 Body_part denotes ascites http://purl.obolibrary.org/obo/UBERON_0007795
T2 925-938 Body_part denotes reticulocytes http://purl.obolibrary.org/obo/CL_0000558
T3 1382-1394 Body_part denotes reticulocyte http://purl.obolibrary.org/obo/CL_0000558
T4 1525-1537 Body_part denotes reticulocyte http://purl.obolibrary.org/obo/CL_0000558

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 109-120 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T2 708-723 Cell denotes nucleated cells http://purl.obolibrary.org/obo/CL:0002242
T3 925-938 Cell denotes reticulocytes http://purl.obolibrary.org/obo/CL:0000558
T4 1382-1394 Cell denotes reticulocyte http://purl.obolibrary.org/obo/CL:0000558
T5 1525-1537 Cell denotes reticulocyte http://purl.obolibrary.org/obo/CL:0000558