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PubMed:8095167 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1165-1172 gene:84106 denotes pml/RAR
T1 1197-1200 disease:C0023487 denotes APL
R1 T0 T1 associated_with pml/RAR,APL

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-21 cell_type denotes Human CD4 lymphocytes
T2 93-107 protein denotes hybrid protein
T3 108-121 protein denotes pml/RAR alpha
T4 133-167 cell_type denotes acute promyelocytic leukemia cells
T5 196-210 cell_type denotes leukemic cells
T6 254-266 protein denotes fusion point
T7 323-336 protein denotes fusion region
T8 360-373 protein denotes pml/RAR alpha
T9 409-449 cell_type denotes acute promyelocytic leukemia (APL) cells
T10 472-491 cell_type denotes human T lymphocytes
T11 502-518 cell_type denotes CD4+ lymphocytes
T12 590-596 protein denotes HLA-DR
T13 636-670 cell_type denotes autologous antigen-presenting cell
T14 672-675 cell_type denotes APC
T15 683-686 cell_type denotes APC
T16 702-731 protein denotes HLA-DR11 restricting molecule
T17 778-781 protein denotes pml
T18 786-804 protein denotes RAR alpha proteins
T19 837-841 cell_line denotes DEG5
T20 897-913 cell_line denotes autologous cells
T21 939-956 cell_line denotes autologous DE LCL
T22 981-1006 DNA denotes pml/RAR alpha fusion gene
T23 1041-1054 protein denotes pml/RAR alpha
T24 1099-1128 cell_line denotes DE anti-BCR1/25 T cell clones
T25 1155-1193 protein denotes bcr1 type-pml/RAR alpha fusion protein
T26 1197-1200 cell_line denotes APL
T27 1287-1309 cell_line denotes human CD4+ lymphocytes

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8095167-0#100#111#gene5371 100-111 gene5371 denotes protein pml
8095167-0#133#161#diseaseC0023487 133-161 diseaseC0023487 denotes acute promyelocytic leukemia
8095167-2#29#33#gene613 297-301 gene613 denotes BCR1
8095167-2#141#169#diseaseC0023487 409-437 diseaseC0023487 denotes acute promyelocytic leukemia
8095167-7#35#42#gene84106 1165-1172 gene84106 denotes pml/RAR
8095167-7#67#70#diseaseC0023487 1197-1200 diseaseC0023487 denotes APL
100#111#gene5371133#161#diseaseC0023487 8095167-0#100#111#gene5371 8095167-0#133#161#diseaseC0023487 associated_with protein pml,acute promyelocytic leukemia
29#33#gene613141#169#diseaseC0023487 8095167-2#29#33#gene613 8095167-2#141#169#diseaseC0023487 associated_with BCR1,acute promyelocytic leukemia
35#42#gene8410667#70#diseaseC0023487 8095167-7#35#42#gene84106 8095167-7#67#70#diseaseC0023487 associated_with pml/RAR,APL

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-168 Sentence denotes Human CD4 lymphocytes specifically recognize a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells.
S2 169-267 Sentence denotes Fusion proteins present in leukemic cells frequently contain a new amino acid at the fusion point.
S3 268-501 Sentence denotes We tested whether a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells, can be recognized by human T lymphocytes in vitro.
S4 502-732 Sentence denotes CD4+ lymphocytes, at both polyclonal and clonal level, recognized peptide BCR1/25 in an HLA-DR--restricted fashion on presentation by autologous antigen-presenting cell (APC) or by APC expressing the HLA-DR11 restricting molecule.
S5 733-825 Sentence denotes Control peptides corresponding to the normal pml and RAR alpha proteins were not recognized.
S6 826-934 Sentence denotes One clone (DEG5) also exerted a high and specific cytotoxicity against autologous cells pulsed with BCR1/25.
S7 935-1129 Sentence denotes The autologous DE LCL containing a transduced pml/RAR alpha fusion gene and expressing a bcr1 type of the pml/RAR alpha hybrid protein induced the proliferation of DE anti-BCR1/25 T cell clones.
S8 1130-1310 Sentence denotes It is concluded that the bcr1 type-pml/RAR alpha fusion protein of APL contains an antigenic site, absent from the normal parent molecules and recognized by human CD4+ lymphocytes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-21 NP denotes Human CD4 lymphocytes
C5 133-167 NP denotes acute promyelocytic leukemia cells
C4 89-167 NP denotes the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
C3 68-167 NP denotes the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
C2 45-167 NP denotes a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
C6 196-210 NP denotes leukemic cells
C9 340-373 NP denotes the hybrid molecule pml/RAR alpha
C10 375-380 NP denotes which
C11 409-449 NP denotes acute promyelocytic leukemia (APL) cells
C8 319-449 NP denotes the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells
C7 286-449 NP denotes a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells
C12 502-518 NP denotes CD4+ lymphocytes
C13 568-583 NP denotes peptide BCR1/25
C14 636-676 NP denotes autologous antigen-presenting cell (APC)
C15 683-731 NP denotes APC expressing the HLA-DR11 restricting molecule
C16 897-913 NP denotes autologous cells
C17 926-933 NP denotes BCR1/25
C18 981-994 NP denotes pml/RAR alpha
C20 1037-1069 NP denotes the pml/RAR alpha hybrid protein
C19 1022-1069 NP denotes a bcr1 type of the pml/RAR alpha hybrid protein
C22 1197-1200 NP denotes APL
C21 1151-1200 NP denotes the bcr1 type-pml/RAR alpha fusion protein of APL
C23 1287-1309 NP denotes human CD4+ lymphocytes
R1 C6 C5 coref-other leukemic cells,acute promyelocytic leukemia cells
R2 C9 C4 coref-other the hybrid molecule pml/RAR alpha,the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
R3 C10 C9 coref-relat which,the hybrid molecule pml/RAR alpha
R4 C11 C5 coref-ident acute promyelocytic leukemia (APL) cells,acute promyelocytic leukemia cells
R5 C8 C3 coref-ident "the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells",the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
R6 C7 C2 coref-ident "a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells",a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
R7 C12 C1 coref-ident CD4+ lymphocytes,Human CD4 lymphocytes
R8 C13 C7 coref-ident peptide BCR1/25,"a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells"
R9 C15 C14 coref-other APC expressing the HLA-DR11 restricting molecule,autologous antigen-presenting cell (APC)
R10 C16 C14 coref-other autologous cells,autologous antigen-presenting cell (APC)
R11 C17 C13 coref-ident BCR1/25,peptide BCR1/25
R12 C18 C9 coref-ident pml/RAR alpha,the hybrid molecule pml/RAR alpha
R13 C20 C4 coref-ident the pml/RAR alpha hybrid protein,the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells
R14 C22 C11 coref-ident APL,acute promyelocytic leukemia (APL) cells
R15 C21 C19 coref-ident the bcr1 type-pml/RAR alpha fusion protein of APL,a bcr1 type of the pml/RAR alpha hybrid protein
R16 C23 C12 coref-ident human CD4+ lymphocytes,CD4+ lymphocytes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-21 cell_type denotes Human CD4 lymphocytes
T2 93-107 protein_family_or_group denotes hybrid protein
T3 108-121 protein_molecule denotes pml/RAR alpha
T4 133-167 cell_type denotes acute promyelocytic leukemia cells
T5 196-210 cell_type denotes leukemic cells
T6 232-246 amino_acid_monomer denotes new amino acid
T7 254-266 protein_domain_or_region denotes fusion point
T8 297-304 peptide denotes BCR1/25
T9 323-336 protein_domain_or_region denotes fusion region
T10 360-373 protein_molecule denotes pml/RAR alpha
T11 409-449 cell_type denotes acute promyelocytic leukemia (APL) cells
T12 472-477 cell_type denotes human
T13 478-491 cell_type denotes T lymphocytes
T14 502-518 cell_type denotes CD4+ lymphocytes
T15 576-583 peptide denotes BCR1/25
T16 590-596 protein_molecule denotes HLA-DR
T17 636-670 cell_type denotes autologous antigen-presenting cell
T18 672-675 cell_type denotes APC
T19 683-686 cell_type denotes APC
T20 702-731 protein_molecule denotes HLA-DR11 restricting molecule
T21 778-781 protein_molecule denotes pml
T22 786-804 protein_molecule denotes RAR alpha proteins
T23 837-841 cell_line denotes DEG5
T24 897-913 cell_line denotes autologous cells
T25 926-933 peptide denotes BCR1/25
T26 939-956 cell_line denotes autologous DE LCL
T27 981-994 protein_molecule denotes pml/RAR alpha
T28 1041-1054 protein_molecule denotes pml/RAR alpha
T29 1099-1128 cell_line denotes DE anti-BCR1/25 T cell clones
T30 1155-1193 protein_molecule denotes bcr1 type-pml/RAR alpha fusion protein
T31 1197-1200 cell_line denotes APL
T32 1287-1309 cell_line denotes human CD4+ lymphocytes