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sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.
T2 145-273 Sentence denotes A large body of evidence indicates that experimental agents which raise cellular cAMP levels inhibit T cell growth and division.
T3 274-446 Sentence denotes By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process.
T4 447-641 Sentence denotes In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB).
T5 642-764 Sentence denotes Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation.
T6 765-941 Sentence denotes All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments.
T7 942-1127 Sentence denotes Binding of the four complexes to CRE is prevented by dephosphorylation of nuclear extracts and is restored by rephosphorylation with cAMP-dependent protein kinase or endogenous kinases.
T8 1128-1195 Sentence denotes Similar complexes are detected in nuclear extracts of Jurkat cells.
T9 1196-1340 Sentence denotes Mitogen induction of the electrophoretic mobility shift assay complexes is not accounted for by protein phosphorylation or by induction of CREB.
T10 1341-1449 Sentence denotes Rather, the data indicate that mitogen increases the levels of a nuclear factor(s) that dimerizes with CREB.
T11 1450-1559 Sentence denotes Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes.
T1 0-144 Sentence denotes Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.
T2 145-273 Sentence denotes A large body of evidence indicates that experimental agents which raise cellular cAMP levels inhibit T cell growth and division.
T3 274-446 Sentence denotes By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process.
T4 447-641 Sentence denotes In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB).
T5 642-764 Sentence denotes Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation.
T6 765-941 Sentence denotes All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments.
T7 942-1127 Sentence denotes Binding of the four complexes to CRE is prevented by dephosphorylation of nuclear extracts and is restored by rephosphorylation with cAMP-dependent protein kinase or endogenous kinases.
T8 1128-1195 Sentence denotes Similar complexes are detected in nuclear extracts of Jurkat cells.
T9 1196-1340 Sentence denotes Mitogen induction of the electrophoretic mobility shift assay complexes is not accounted for by protein phosphorylation or by induction of CREB.
T10 1341-1449 Sentence denotes Rather, the data indicate that mitogen increases the levels of a nuclear factor(s) that dimerizes with CREB.
T11 1450-1559 Sentence denotes Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-52 cell_type denotes human peripheral T lymphocytes
T2 82-143 protein denotes cyclic AMP response element-binding protein nuclear complexes
T3 319-326 protein denotes mitogen
T4 341-348 cell_type denotes T cells
T5 488-495 protein denotes mitogen
T6 510-540 cell_type denotes human peripheral T lymphocytes
T7 590-633 protein denotes cyclic AMP response element-binding protein
T8 635-639 protein denotes CREB
T9 745-752 protein denotes mitogen
T10 792-796 protein denotes CREB
T11 818-859 DNA denotes cAMP response element (CRE) core sequence
T12 975-978 DNA denotes CRE
T13 1075-1104 protein denotes cAMP-dependent protein kinase
T14 1108-1126 protein denotes endogenous kinases
T15 1182-1194 cell_line denotes Jurkat cells
T16 1221-1267 protein denotes electrophoretic mobility shift assay complexes
T17 1335-1339 protein denotes CREB
T18 1444-1448 protein denotes CREB
T19 1467-1481 protein denotes CREB complexes
T20 1523-1530 protein denotes mitogen
T21 1545-1558 cell_type denotes T lymphocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-144 Sentence denotes Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.
S2 145-273 Sentence denotes A large body of evidence indicates that experimental agents which raise cellular cAMP levels inhibit T cell growth and division.
S3 274-446 Sentence denotes By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process.
S4 447-641 Sentence denotes In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB).
S5 642-764 Sentence denotes Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation.
S6 765-941 Sentence denotes All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments.
S7 942-1127 Sentence denotes Binding of the four complexes to CRE is prevented by dephosphorylation of nuclear extracts and is restored by rephosphorylation with cAMP-dependent protein kinase or endogenous kinases.
S8 1128-1195 Sentence denotes Similar complexes are detected in nuclear extracts of Jurkat cells.
S9 1196-1340 Sentence denotes Mitogen induction of the electrophoretic mobility shift assay complexes is not accounted for by protein phosphorylation or by induction of CREB.
S10 1341-1449 Sentence denotes Rather, the data indicate that mitogen increases the levels of a nuclear factor(s) that dimerizes with CREB.
S11 1450-1559 Sentence denotes Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-52 NP denotes Mitogen activation of human peripheral T lymphocytes
C2 78-143 NP denotes new cyclic AMP response element-binding protein nuclear complexes
C3 185-204 NP denotes experimental agents
C4 205-210 NP denotes which
C5 217-237 NP denotes cellular cAMP levels
C6 319-348 NP denotes mitogen activation of T cells
C7 359-370 NP denotes cAMP levels
C8 415-419 NP denotes cAMP
C9 488-540 NP denotes mitogen activation of human peripheral T lymphocytes
C10 549-564 NP denotes nuclear factors
C11 565-569 NP denotes that
C13 590-640 NP denotes cyclic AMP response element-binding protein (CREB)
C12 575-640 NP denotes complexes with cyclic AMP response element-binding protein (CREB)
C14 642-656 NP denotes Four complexes
C15 717-720 NP denotes two
C16 724-729 NP denotes which
C17 765-783 NP denotes All four complexes
C18 792-796 NP denotes CREB
C19 953-971 NP denotes the four complexes
C20 1217-1267 NP denotes the electrophoretic mobility shift assay complexes
C21 1335-1339 NP denotes CREB
C22 1404-1423 NP denotes a nuclear factor(s)
C23 1424-1428 NP denotes that
C24 1444-1448 NP denotes CREB
C25 1515-1519 NP denotes cAMP
C26 1523-1558 NP denotes mitogen activation of T lymphocytes
R1 C4 C3 coref-relat which,experimental agents
R2 C6 C1 coref-ident mitogen activation of T cells,Mitogen activation of human peripheral T lymphocytes
R3 C7 C5 coref-ident cAMP levels,cellular cAMP levels
R4 C9 C6 coref-ident mitogen activation of human peripheral T lymphocytes,mitogen activation of T cells
R5 C11 C10 coref-relat that,nuclear factors
R6 C12 C2 coref-ident complexes with cyclic AMP response element-binding protein (CREB),new cyclic AMP response element-binding protein nuclear complexes
R7 C15 C14 coref-pron two,Four complexes
R8 C16 C14 coref-relat which,Four complexes
R9 C17 C14 coref-ident All four complexes,Four complexes
R10 C18 C13 coref-ident CREB,cyclic AMP response element-binding protein (CREB)
R11 C19 C17 coref-ident the four complexes,All four complexes
R12 C20 C14 coref-ident the electrophoretic mobility shift assay complexes,Four complexes
R13 C21 C18 coref-ident CREB,CREB
R14 C23 C22 coref-relat that,a nuclear factor(s)
R15 C24 C21 coref-ident CREB,CREB
R16 C25 C8 coref-ident cAMP,cAMP
R17 C26 C9 coref-ident mitogen activation of T lymphocytes,mitogen activation of human peripheral T lymphocytes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-18 other_name denotes Mitogen activation
T2 22-38 cell_type denotes human peripheral
T3 39-52 cell_type denotes T lymphocytes
T4 82-92 nucleotide denotes cyclic AMP
T5 185-204 other_name denotes experimental agents
T6 217-225 other_name denotes cellular
T7 226-230 nucleotide denotes cAMP
T8 246-259 other_name denotes T cell growth
T9 319-326 protein_family_or_group denotes mitogen
T10 341-348 cell_type denotes T cells
T11 359-363 nucleotide denotes cAMP
T12 415-419 nucleotide denotes cAMP
T13 488-495 protein_family_or_group denotes mitogen
T14 510-526 cell_type denotes human peripheral
T15 527-540 cell_type denotes T lymphocytes
T16 590-600 nucleotide denotes cyclic AMP
T17 635-639 protein_molecule denotes CREB
T18 679-715 other_name denotes electrophoretic mobility shift assay
T19 745-752 protein_family_or_group denotes mitogen
T20 792-796 protein_molecule denotes CREB
T21 818-822 nucleotide denotes cAMP
T22 841-844 DNA_domain_or_region denotes CRE
T23 861-869 polynucleotide denotes TGACGTCA
T24 901-916 polynucleotide denotes oligonucleotide
T25 975-978 DNA_domain_or_region denotes CRE
T26 1075-1079 nucleotide denotes cAMP
T27 1108-1126 protein_family_or_group denotes endogenous kinases
T28 1162-1178 cell_component denotes nuclear extracts
T29 1182-1194 cell_line denotes Jurkat cells
T30 1221-1257 other_name denotes electrophoretic mobility shift assay
T31 1335-1339 protein_molecule denotes CREB
T32 1372-1379 other_organic_compound denotes mitogen
T33 1444-1448 protein_molecule denotes CREB
T34 1467-1471 protein_molecule denotes CREB
T35 1515-1519 nucleotide denotes cAMP
T36 1523-1530 protein_family_or_group denotes mitogen
T37 1545-1558 cell_type denotes T lymphocytes

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 22-27 OrganismTaxon denotes human 9606
T2 510-515 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 39-52 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T2 126-143 Body_part denotes nuclear complexes http://purl.obolibrary.org/obo/UBERON_0007245
T3 246-252 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T4 527-540 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T5 1545-1558 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 39-52 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T2 246-252 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T3 341-348 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 527-540 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T5 1545-1558 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084