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PubMed:803971 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 0-16 Glycan_Motif denotes Lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T4 185-201 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T7 346-349 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T9 559-575 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T12 622-625 Glycan_Motif denotes Gm1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T14 1062-1078 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T17 1153-1171 Glycan_Motif denotes galactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T18 1530-1533 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T20 2319-2337 Glycan_Motif denotes galactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T21 2367-2383 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T24 2496-2512 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT

sentences

Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Lactosylceramide beta-galactosidase in human sphingolipidoses.
T2 63-109 Sentence denotes Evidence for two genetically distinct enzymes.
T3 110-365 Sentence denotes In view of recent conflicting reports from two laboratories, activities of lactosylceramide beta-galactosidase were reinvestigated in detail in brains and livers of normal individuals and of patients with globoid cell leukodystrophy or GM1-gangliosidosis.
T4 366-523 Sentence denotes Both sets of the apparently totally contradictory results were readily reproduced simply by using the different assay systems of the respective laboratories.
T5 524-813 Sentence denotes With our own assay system, hepatic lactosylceramide beta-galactosidase appeared deficient only in Gm1-gangliosidosis, while it appeared deficient only in globoid cell leukodystrophy when the assay system of Wenger et al. (Wenger, D.A., Sattler, M., Clark, D., and McKelvey, H. (1974) Clin.
T6 814-819 Sentence denotes Chim.
T7 820-847 Sentence denotes Acta 56, 199-206) was used.
T8 848-978 Sentence denotes Analyses of individual constitutents in the two assay systems revealed their complex effects on measured activities of the enzyme.
T9 979-1096 Sentence denotes The findings were strongly indicative of the existence of two genetically distinct lactosylceramide-cleaving enzymes.
T10 1097-1305 Sentence denotes One enzyme (lactosylceramidase I) may be identical with galactosylceramide betal-galactosidase, and the other (lactosylceramidase II) is closely related to nonspecific 4-methylumbelliferyl beta-galactosidase.
T11 1306-1427 Sentence denotes Normal human brain contains mostly lactosylceramidase I, while normal liver contains predominantly lactosylceramidase II.
T12 1428-1549 Sentence denotes Lactosylceramidase I is genetically lacking globoid cell leukodystrophy, and lactosylceramidase II in GM1-gangliosidosis.
T13 1550-1687 Sentence denotes Lactosylceramidase I is activated by either pure or crude taurocholate and by oleic acid and is only slightly activated by chloride ions.
T14 1688-1774 Sentence denotes Lactosylceramidase II is activated by crude taurocholate but not by pure taurocholate.
T15 1775-1877 Sentence denotes As activators, oleic acid is less effective and chloride more effective than for lactosylceramidase I.
T16 1878-2014 Sentence denotes Citrate-phosphate buffer is more favorable to lactosylceramidase I than citrate buffer, while lactosylceramidase II responds in reverse.
T17 2015-2229 Sentence denotes The standard assay system used by Wenger et al. determines almost exclusively lactosylceramidase I, while our own standard system is optimal for lactosylceramidase II and is less favorable for lactosylceramidase I.
T18 2230-2492 Sentence denotes With a highly purified human hepatic beta-galactosidase preparation, exxentially free of galactosylceramide beta-galactosidase activity, lactosylceramide-cleaving activity determined by the Wenger system was less than 2 per cent of that determined by our system.
T19 2493-2711 Sentence denotes If lactosylceramide beta-balactosidase assays are to be used for diagnosis of globoid cell leukodystrophy, it is absolutely essential to use an appropriate assay system in order to avoid errors of serious consequences.
T1 0-62 Sentence denotes Lactosylceramide beta-galactosidase in human sphingolipidoses.
T2 63-109 Sentence denotes Evidence for two genetically distinct enzymes.
T3 110-365 Sentence denotes In view of recent conflicting reports from two laboratories, activities of lactosylceramide beta-galactosidase were reinvestigated in detail in brains and livers of normal individuals and of patients with globoid cell leukodystrophy or GM1-gangliosidosis.
T4 366-523 Sentence denotes Both sets of the apparently totally contradictory results were readily reproduced simply by using the different assay systems of the respective laboratories.
T5 524-813 Sentence denotes With our own assay system, hepatic lactosylceramide beta-galactosidase appeared deficient only in Gm1-gangliosidosis, while it appeared deficient only in globoid cell leukodystrophy when the assay system of Wenger et al. (Wenger, D.A., Sattler, M., Clark, D., and McKelvey, H. (1974) Clin.
T6 814-819 Sentence denotes Chim.
T7 820-847 Sentence denotes Acta 56, 199-206) was used.
T8 848-978 Sentence denotes Analyses of individual constitutents in the two assay systems revealed their complex effects on measured activities of the enzyme.
T9 979-1096 Sentence denotes The findings were strongly indicative of the existence of two genetically distinct lactosylceramide-cleaving enzymes.
T10 1097-1305 Sentence denotes One enzyme (lactosylceramidase I) may be identical with galactosylceramide betal-galactosidase, and the other (lactosylceramidase II) is closely related to nonspecific 4-methylumbelliferyl beta-galactosidase.
T11 1306-1427 Sentence denotes Normal human brain contains mostly lactosylceramidase I, while normal liver contains predominantly lactosylceramidase II.
T12 1428-1549 Sentence denotes Lactosylceramidase I is genetically lacking globoid cell leukodystrophy, and lactosylceramidase II in GM1-gangliosidosis.
T13 1550-1687 Sentence denotes Lactosylceramidase I is activated by either pure or crude taurocholate and by oleic acid and is only slightly activated by chloride ions.
T14 1688-1774 Sentence denotes Lactosylceramidase II is activated by crude taurocholate but not by pure taurocholate.
T15 1775-1877 Sentence denotes As activators, oleic acid is less effective and chloride more effective than for lactosylceramidase I.
T16 1878-2014 Sentence denotes Citrate-phosphate buffer is more favorable to lactosylceramidase I than citrate buffer, while lactosylceramidase II responds in reverse.
T17 2015-2229 Sentence denotes The standard assay system used by Wenger et al. determines almost exclusively lactosylceramidase I, while our own standard system is optimal for lactosylceramidase II and is less favorable for lactosylceramidase I.
T18 2230-2492 Sentence denotes With a highly purified human hepatic beta-galactosidase preparation, exxentially free of galactosylceramide beta-galactosidase activity, lactosylceramide-cleaving activity determined by the Wenger system was less than 2 per cent of that determined by our system.
T19 2493-2711 Sentence denotes If lactosylceramide beta-balactosidase assays are to be used for diagnosis of globoid cell leukodystrophy, it is absolutely essential to use an appropriate assay system in order to avoid errors of serious consequences.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 0-16 https://glytoucan.org/Structures/Glycans/G20420WT denotes Lactosylceramide
T2 0-16 https://glytoucan.org/Structures/Glycans/G74621DY denotes Lactosylceramide
T3 0-16 https://glytoucan.org/Structures/Glycans/G84224TW denotes Lactosylceramide
T4 185-201 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T5 185-201 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T6 185-201 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T7 346-349 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T8 346-349 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T9 559-575 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T10 559-575 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T11 559-575 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T12 622-625 https://glytoucan.org/Structures/Glycans/G46613JI denotes Gm1
T13 622-625 https://glytoucan.org/Structures/Glycans/G48558GR denotes Gm1
T14 1062-1078 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T15 1062-1078 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T16 1062-1078 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T17 1153-1171 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactosylceramide
T18 1530-1533 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T19 1530-1533 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T20 2319-2337 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactosylceramide
T21 2367-2383 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T22 2367-2383 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T23 2367-2383 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T24 2496-2512 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T25 2496-2512 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T26 2496-2512 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 254-260 http://purl.obolibrary.org/obo/MAT_0000098 denotes brains
T2 265-271 http://purl.obolibrary.org/obo/MAT_0000097 denotes livers
T3 1319-1324 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 1376-1381 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 0-16 http://www.glycoepitope.jp/epitopes/EP0078 denotes Lactosylceramide
T2 185-201 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
T3 346-349 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T4 559-575 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
T5 1062-1078 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
T6 1153-1171 http://www.glycoepitope.jp/epitopes/EP0074 denotes galactosylceramide
T7 1530-1533 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T8 2319-2337 http://www.glycoepitope.jp/epitopes/EP0074 denotes galactosylceramide
T9 2367-2383 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
T10 2496-2512 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 45-61 Disease denotes sphingolipidoses http://purl.obolibrary.org/obo/MONDO_0019255
T2 315-342 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499
T3 346-364 Disease denotes GM1-gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T4 622-640 Disease denotes Gm1-gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T5 678-705 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499
T6 1472-1499 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499
T7 1530-1548 Disease denotes GM1-gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T8 2571-2598 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 254-260 Body_part denotes brains http://purl.obolibrary.org/obo/MAT_0000098
T2 265-271 Body_part denotes livers http://purl.obolibrary.org/obo/MAT_0000097
T3 1319-1324 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 1376-1381 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 328-342 Phenotype denotes leukodystrophy HP:0002415
T2 691-705 Phenotype denotes leukodystrophy HP:0002415
T3 1485-1499 Phenotype denotes leukodystrophy HP:0002415
T4 2584-2598 Phenotype denotes leukodystrophy HP:0002415

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 0-16 Glycan denotes Lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T2 185-201 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T3 346-349 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 559-575 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T5 1062-1078 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T6 1153-1171 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T7 1530-1533 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T8 2319-2337 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T9 2367-2383 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 2496-2512 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 0-16 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T2 185-201 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T3 346-349 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 559-575 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T5 1062-1078 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T6 1153-1171 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T7 1530-1533 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T8 2319-2337 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T9 2367-2383 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T10 2496-2512 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 328-342 Phenotype denotes leukodystrophy HP:0002415
T2 691-705 Phenotype denotes leukodystrophy HP:0002415
T3 1485-1499 Phenotype denotes leukodystrophy HP:0002415
T4 2584-2598 Phenotype denotes leukodystrophy HP:0002415

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 45-61 Disease denotes sphingolipidoses http://purl.obolibrary.org/obo/MONDO_0019255
T2 315-342 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499
T3 346-364 Disease denotes GM1-gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T4 622-640 Disease denotes Gm1-gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T5 678-705 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499
T6 1472-1499 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499
T7 1530-1548 Disease denotes GM1-gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T8 2571-2598 Disease denotes globoid cell leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009499

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 39-44 OrganismTaxon denotes human 9606
T2 1313-1318 OrganismTaxon denotes human 9606
T3 2253-2258 OrganismTaxon denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1319-1324 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 1376-1381 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 254-260 Body_part denotes brains http://purl.obolibrary.org/obo/MAT_0000098
T2 265-271 Body_part denotes livers http://purl.obolibrary.org/obo/MAT_0000097
T3 1319-1324 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 1376-1381 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

sentences

Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Lactosylceramide beta-galactosidase in human sphingolipidoses.
T2 63-109 Sentence denotes Evidence for two genetically distinct enzymes.
T3 110-365 Sentence denotes In view of recent conflicting reports from two laboratories, activities of lactosylceramide beta-galactosidase were reinvestigated in detail in brains and livers of normal individuals and of patients with globoid cell leukodystrophy or GM1-gangliosidosis.
T4 366-523 Sentence denotes Both sets of the apparently totally contradictory results were readily reproduced simply by using the different assay systems of the respective laboratories.
T5 524-813 Sentence denotes With our own assay system, hepatic lactosylceramide beta-galactosidase appeared deficient only in Gm1-gangliosidosis, while it appeared deficient only in globoid cell leukodystrophy when the assay system of Wenger et al. (Wenger, D.A., Sattler, M., Clark, D., and McKelvey, H. (1974) Clin.
T6 814-819 Sentence denotes Chim.
T7 820-847 Sentence denotes Acta 56, 199-206) was used.
T8 848-978 Sentence denotes Analyses of individual constitutents in the two assay systems revealed their complex effects on measured activities of the enzyme.
T9 979-1096 Sentence denotes The findings were strongly indicative of the existence of two genetically distinct lactosylceramide-cleaving enzymes.
T10 1097-1305 Sentence denotes One enzyme (lactosylceramidase I) may be identical with galactosylceramide betal-galactosidase, and the other (lactosylceramidase II) is closely related to nonspecific 4-methylumbelliferyl beta-galactosidase.
T11 1306-1427 Sentence denotes Normal human brain contains mostly lactosylceramidase I, while normal liver contains predominantly lactosylceramidase II.
T12 1428-1549 Sentence denotes Lactosylceramidase I is genetically lacking globoid cell leukodystrophy, and lactosylceramidase II in GM1-gangliosidosis.
T13 1550-1687 Sentence denotes Lactosylceramidase I is activated by either pure or crude taurocholate and by oleic acid and is only slightly activated by chloride ions.
T14 1688-1774 Sentence denotes Lactosylceramidase II is activated by crude taurocholate but not by pure taurocholate.
T15 1775-1877 Sentence denotes As activators, oleic acid is less effective and chloride more effective than for lactosylceramidase I.
T16 1878-2014 Sentence denotes Citrate-phosphate buffer is more favorable to lactosylceramidase I than citrate buffer, while lactosylceramidase II responds in reverse.
T17 2015-2229 Sentence denotes The standard assay system used by Wenger et al. determines almost exclusively lactosylceramidase I, while our own standard system is optimal for lactosylceramidase II and is less favorable for lactosylceramidase I.
T18 2230-2492 Sentence denotes With a highly purified human hepatic beta-galactosidase preparation, exxentially free of galactosylceramide beta-galactosidase activity, lactosylceramide-cleaving activity determined by the Wenger system was less than 2 per cent of that determined by our system.
T19 2493-2711 Sentence denotes If lactosylceramide beta-balactosidase assays are to be used for diagnosis of globoid cell leukodystrophy, it is absolutely essential to use an appropriate assay system in order to avoid errors of serious consequences.
T1 0-62 Sentence denotes Lactosylceramide beta-galactosidase in human sphingolipidoses.
T2 63-109 Sentence denotes Evidence for two genetically distinct enzymes.
T3 110-365 Sentence denotes In view of recent conflicting reports from two laboratories, activities of lactosylceramide beta-galactosidase were reinvestigated in detail in brains and livers of normal individuals and of patients with globoid cell leukodystrophy or GM1-gangliosidosis.
T4 366-523 Sentence denotes Both sets of the apparently totally contradictory results were readily reproduced simply by using the different assay systems of the respective laboratories.
T5 524-813 Sentence denotes With our own assay system, hepatic lactosylceramide beta-galactosidase appeared deficient only in Gm1-gangliosidosis, while it appeared deficient only in globoid cell leukodystrophy when the assay system of Wenger et al. (Wenger, D.A., Sattler, M., Clark, D., and McKelvey, H. (1974) Clin.
T6 814-819 Sentence denotes Chim.
T7 820-847 Sentence denotes Acta 56, 199-206) was used.
T8 848-978 Sentence denotes Analyses of individual constitutents in the two assay systems revealed their complex effects on measured activities of the enzyme.
T9 979-1096 Sentence denotes The findings were strongly indicative of the existence of two genetically distinct lactosylceramide-cleaving enzymes.
T10 1097-1305 Sentence denotes One enzyme (lactosylceramidase I) may be identical with galactosylceramide betal-galactosidase, and the other (lactosylceramidase II) is closely related to nonspecific 4-methylumbelliferyl beta-galactosidase.
T11 1306-1427 Sentence denotes Normal human brain contains mostly lactosylceramidase I, while normal liver contains predominantly lactosylceramidase II.
T12 1428-1549 Sentence denotes Lactosylceramidase I is genetically lacking globoid cell leukodystrophy, and lactosylceramidase II in GM1-gangliosidosis.
T13 1550-1687 Sentence denotes Lactosylceramidase I is activated by either pure or crude taurocholate and by oleic acid and is only slightly activated by chloride ions.
T14 1688-1774 Sentence denotes Lactosylceramidase II is activated by crude taurocholate but not by pure taurocholate.
T15 1775-1877 Sentence denotes As activators, oleic acid is less effective and chloride more effective than for lactosylceramidase I.
T16 1878-2014 Sentence denotes Citrate-phosphate buffer is more favorable to lactosylceramidase I than citrate buffer, while lactosylceramidase II responds in reverse.
T17 2015-2229 Sentence denotes The standard assay system used by Wenger et al. determines almost exclusively lactosylceramidase I, while our own standard system is optimal for lactosylceramidase II and is less favorable for lactosylceramidase I.
T18 2230-2492 Sentence denotes With a highly purified human hepatic beta-galactosidase preparation, exxentially free of galactosylceramide beta-galactosidase activity, lactosylceramide-cleaving activity determined by the Wenger system was less than 2 per cent of that determined by our system.
T19 2493-2711 Sentence denotes If lactosylceramide beta-balactosidase assays are to be used for diagnosis of globoid cell leukodystrophy, it is absolutely essential to use an appropriate assay system in order to avoid errors of serious consequences.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Lactosylceramide beta-galactosidase in human sphingolipidoses.
T2 63-109 Sentence denotes Evidence for two genetically distinct enzymes.
T3 110-365 Sentence denotes In view of recent conflicting reports from two laboratories, activities of lactosylceramide beta-galactosidase were reinvestigated in detail in brains and livers of normal individuals and of patients with globoid cell leukodystrophy or GM1-gangliosidosis.
T4 366-523 Sentence denotes Both sets of the apparently totally contradictory results were readily reproduced simply by using the different assay systems of the respective laboratories.
T5 524-847 Sentence denotes With our own assay system, hepatic lactosylceramide beta-galactosidase appeared deficient only in Gm1-gangliosidosis, while it appeared deficient only in globoid cell leukodystrophy when the assay system of Wenger et al. (Wenger, D.A., Sattler, M., Clark, D., and McKelvey, H. (1974) Clin. Chim. Acta 56, 199-206) was used.
T6 848-978 Sentence denotes Analyses of individual constitutents in the two assay systems revealed their complex effects on measured activities of the enzyme.
T7 979-1096 Sentence denotes The findings were strongly indicative of the existence of two genetically distinct lactosylceramide-cleaving enzymes.
T8 1097-1305 Sentence denotes One enzyme (lactosylceramidase I) may be identical with galactosylceramide betal-galactosidase, and the other (lactosylceramidase II) is closely related to nonspecific 4-methylumbelliferyl beta-galactosidase.
T9 1306-1427 Sentence denotes Normal human brain contains mostly lactosylceramidase I, while normal liver contains predominantly lactosylceramidase II.
T10 1428-1549 Sentence denotes Lactosylceramidase I is genetically lacking globoid cell leukodystrophy, and lactosylceramidase II in GM1-gangliosidosis.
T11 1550-1687 Sentence denotes Lactosylceramidase I is activated by either pure or crude taurocholate and by oleic acid and is only slightly activated by chloride ions.
T12 1688-1774 Sentence denotes Lactosylceramidase II is activated by crude taurocholate but not by pure taurocholate.
T13 1775-2014 Sentence denotes As activators, oleic acid is less effective and chloride more effective than for lactosylceramidase I. Citrate-phosphate buffer is more favorable to lactosylceramidase I than citrate buffer, while lactosylceramidase II responds in reverse.
T14 2015-2492 Sentence denotes The standard assay system used by Wenger et al. determines almost exclusively lactosylceramidase I, while our own standard system is optimal for lactosylceramidase II and is less favorable for lactosylceramidase I. With a highly purified human hepatic beta-galactosidase preparation, exxentially free of galactosylceramide beta-galactosidase activity, lactosylceramide-cleaving activity determined by the Wenger system was less than 2 per cent of that determined by our system.
T15 2493-2711 Sentence denotes If lactosylceramide beta-balactosidase assays are to be used for diagnosis of globoid cell leukodystrophy, it is absolutely essential to use an appropriate assay system in order to avoid errors of serious consequences.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 0-16 Glycan denotes Lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T2 185-201 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T3 346-349 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 559-575 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T5 1062-1078 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T6 1153-1171 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T7 1530-1533 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T8 2319-2337 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T9 2367-2383 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 2496-2512 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 0-16 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T2 185-201 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T3 346-349 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 559-575 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T5 1062-1078 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T6 1153-1171 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T7 1530-1533 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T8 2319-2337 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T9 2367-2383 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T10 2496-2512 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 39-44 OrganismTaxon denotes human 9606
T2 1313-1318 OrganismTaxon denotes human 9606
T3 2253-2258 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1319-1324 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 1376-1381 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107