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PubMed:8034715 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 118-128 Cell denotes basophilic http://purl.obolibrary.org/obo/CL:0000767
T2 244-254 Cell denotes basophilic http://purl.obolibrary.org/obo/CL:0000767
T3 415-422 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T4 435-442 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T5 597-604 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T6 715-722 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T7 855-862 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T8 878-885 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T9 1031-1038 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T10 1240-1247 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T11 1369-1376 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T12 1587-1594 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T13 1684-1691 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T14 1848-1855 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 232-236 Glycan_Motif denotes GD1b https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G97612UN|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G37184KW

sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells.
T2 145-280 Sentence denotes The monoclonal antibody AA4 (mAb AA4) recognizes novel alpha-galactosyl derivatives of GD1b on rat basophilic leukemia (RBL-2H3) cells.
T3 281-372 Sentence denotes The binding of mAb AA4 induced protein tyrosine phosphorylations without histamine release.
T4 373-608 Sentence denotes Several of the same proteins including Fc epsilon RI beta, Fc epsilon RI gamma, p72syk, and phospholipase C-gamma 1 were tyrosine-phosphorylated by mAb AA4 binding and by the activation of the high affinity IgE receptor, Fc epsilon RI.
T5 609-929 Sentence denotes There was also activation of the p53/56lyn and p72syk protein-tyrosine kinases, but compared to direct Fc epsilon RI activation, mAb AA4 did not result in increased tyrosine phosphorylation of pp105-115 or pp125FAK, and the receptor subunits (Fc epsilon RI beta and Fc epsilon RI gamma) were more heavily phosphorylated.
T6 930-1054 Sentence denotes Furthermore, the time course of the phosphorylations with mAb AA4 was slower than that induced by Fc epsilon RI aggregation.
T7 1055-1305 Sentence denotes By immunofluorescence, the tyrosine-phosphorylated proteins after mAb AA4 stimulation were localized in patches at the cell membrane and in areas of cell-cell contact, whereas after Fc epsilon RI activation, there was a reticular cytoplasmic pattern.
T8 1306-1518 Sentence denotes There were no protein tyrosine phosphorylations either when Fc epsilon RI was saturated with IgE or when F(ab')2 fragments of mAb AA4 were used, although the F(ab')2 fragments still induced morphological changes.
T9 1519-1633 Sentence denotes There was also coprecipitation of the beta and gamma subunits of Fc epsilon RI with the anti-ganglioside antibody.
T10 1634-1760 Sentence denotes These data strongly suggest the involvement of Fc epsilon RI in the antiganglioside-induced protein tyrosine phosphorylations.
T11 1761-1934 Sentence denotes Moreover, phosphorylations of these proteins including the beta and gamma chains of Fc epsilon RI and activation of p53/56lyn and p72syk did not result in histamine release.
T1 0-144 Sentence denotes The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells.
T2 145-280 Sentence denotes The monoclonal antibody AA4 (mAb AA4) recognizes novel alpha-galactosyl derivatives of GD1b on rat basophilic leukemia (RBL-2H3) cells.
T3 281-372 Sentence denotes The binding of mAb AA4 induced protein tyrosine phosphorylations without histamine release.
T4 373-608 Sentence denotes Several of the same proteins including Fc epsilon RI beta, Fc epsilon RI gamma, p72syk, and phospholipase C-gamma 1 were tyrosine-phosphorylated by mAb AA4 binding and by the activation of the high affinity IgE receptor, Fc epsilon RI.
T5 609-929 Sentence denotes There was also activation of the p53/56lyn and p72syk protein-tyrosine kinases, but compared to direct Fc epsilon RI activation, mAb AA4 did not result in increased tyrosine phosphorylation of pp105-115 or pp125FAK, and the receptor subunits (Fc epsilon RI beta and Fc epsilon RI gamma) were more heavily phosphorylated.
T6 930-1054 Sentence denotes Furthermore, the time course of the phosphorylations with mAb AA4 was slower than that induced by Fc epsilon RI aggregation.
T7 1055-1305 Sentence denotes By immunofluorescence, the tyrosine-phosphorylated proteins after mAb AA4 stimulation were localized in patches at the cell membrane and in areas of cell-cell contact, whereas after Fc epsilon RI activation, there was a reticular cytoplasmic pattern.
T8 1306-1518 Sentence denotes There were no protein tyrosine phosphorylations either when Fc epsilon RI was saturated with IgE or when F(ab')2 fragments of mAb AA4 were used, although the F(ab')2 fragments still induced morphological changes.
T9 1519-1633 Sentence denotes There was also coprecipitation of the beta and gamma subunits of Fc epsilon RI with the anti-ganglioside antibody.
T10 1634-1760 Sentence denotes These data strongly suggest the involvement of Fc epsilon RI in the antiganglioside-induced protein tyrosine phosphorylations.
T11 1761-1934 Sentence denotes Moreover, phosphorylations of these proteins including the beta and gamma chains of Fc epsilon RI and activation of p53/56lyn and p72syk did not result in histamine release.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 232-236 https://glytoucan.org/Structures/Glycans/G37184KW denotes GD1b
T2 232-236 https://glytoucan.org/Structures/Glycans/G97612UN denotes GD1b

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 41-44 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T2 169-172 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T3 178-181 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T4 232-236 http://www.glycoepitope.jp/epitopes/EP0059 denotes GD1b
T5 300-303 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T6 525-528 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T7 742-745 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T8 992-995 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T9 1125-1128 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4
T10 1436-1439 http://www.glycoepitope.jp/epitopes/AN0285 denotes AA4

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 129-137 Phenotype denotes leukemia HP:0001909
T2 255-263 Phenotype denotes leukemia HP:0001909

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 118-137 Disease denotes basophilic leukemia http://purl.obolibrary.org/obo/MONDO_0019458
T2 244-263 Disease denotes basophilic leukemia http://purl.obolibrary.org/obo/MONDO_0019458

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 232-236 Glycan denotes GD1b https://api.glycosmos.org/wurcs2image/latest/png/binary/G37184KW

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 41-44 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T2 169-172 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T3 178-181 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T4 232-236 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1b http://www.glycoepitope.jp/epitopes/EP0059
T5 300-303 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T6 525-528 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T7 742-745 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T8 992-995 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T9 1125-1128 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T10 1436-1439 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 129-137 Phenotype denotes leukemia HP:0001909
T2 255-263 Phenotype denotes leukemia HP:0001909

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 118-137 Disease denotes basophilic leukemia http://purl.obolibrary.org/obo/MONDO_0019458
T2 244-263 Disease denotes basophilic leukemia http://purl.obolibrary.org/obo/MONDO_0019458

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 114-117 OrganismTaxon denotes rat 10114|10116
T3 240-243 OrganismTaxon denotes rat 10114|10116

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 118-128 Cell denotes basophilic http://purl.obolibrary.org/obo/CL:0000767
T2 244-254 Cell denotes basophilic http://purl.obolibrary.org/obo/CL:0000767
T3 415-422 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T4 435-442 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T5 597-604 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T6 715-722 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T7 855-862 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T8 878-885 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T9 1031-1038 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T10 1240-1247 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T11 1369-1376 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T12 1587-1594 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T13 1684-1691 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T14 1848-1855 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1174-1187 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886
T2 1285-1296 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737

sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells.
T2 145-280 Sentence denotes The monoclonal antibody AA4 (mAb AA4) recognizes novel alpha-galactosyl derivatives of GD1b on rat basophilic leukemia (RBL-2H3) cells.
T3 281-372 Sentence denotes The binding of mAb AA4 induced protein tyrosine phosphorylations without histamine release.
T4 373-608 Sentence denotes Several of the same proteins including Fc epsilon RI beta, Fc epsilon RI gamma, p72syk, and phospholipase C-gamma 1 were tyrosine-phosphorylated by mAb AA4 binding and by the activation of the high affinity IgE receptor, Fc epsilon RI.
T5 609-929 Sentence denotes There was also activation of the p53/56lyn and p72syk protein-tyrosine kinases, but compared to direct Fc epsilon RI activation, mAb AA4 did not result in increased tyrosine phosphorylation of pp105-115 or pp125FAK, and the receptor subunits (Fc epsilon RI beta and Fc epsilon RI gamma) were more heavily phosphorylated.
T6 930-1054 Sentence denotes Furthermore, the time course of the phosphorylations with mAb AA4 was slower than that induced by Fc epsilon RI aggregation.
T7 1055-1305 Sentence denotes By immunofluorescence, the tyrosine-phosphorylated proteins after mAb AA4 stimulation were localized in patches at the cell membrane and in areas of cell-cell contact, whereas after Fc epsilon RI activation, there was a reticular cytoplasmic pattern.
T8 1306-1518 Sentence denotes There were no protein tyrosine phosphorylations either when Fc epsilon RI was saturated with IgE or when F(ab')2 fragments of mAb AA4 were used, although the F(ab')2 fragments still induced morphological changes.
T9 1519-1633 Sentence denotes There was also coprecipitation of the beta and gamma subunits of Fc epsilon RI with the anti-ganglioside antibody.
T10 1634-1760 Sentence denotes These data strongly suggest the involvement of Fc epsilon RI in the antiganglioside-induced protein tyrosine phosphorylations.
T11 1761-1934 Sentence denotes Moreover, phosphorylations of these proteins including the beta and gamma chains of Fc epsilon RI and activation of p53/56lyn and p72syk did not result in histamine release.
T1 0-144 Sentence denotes The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells.
T2 145-280 Sentence denotes The monoclonal antibody AA4 (mAb AA4) recognizes novel alpha-galactosyl derivatives of GD1b on rat basophilic leukemia (RBL-2H3) cells.
T3 281-372 Sentence denotes The binding of mAb AA4 induced protein tyrosine phosphorylations without histamine release.
T4 373-608 Sentence denotes Several of the same proteins including Fc epsilon RI beta, Fc epsilon RI gamma, p72syk, and phospholipase C-gamma 1 were tyrosine-phosphorylated by mAb AA4 binding and by the activation of the high affinity IgE receptor, Fc epsilon RI.
T5 609-929 Sentence denotes There was also activation of the p53/56lyn and p72syk protein-tyrosine kinases, but compared to direct Fc epsilon RI activation, mAb AA4 did not result in increased tyrosine phosphorylation of pp105-115 or pp125FAK, and the receptor subunits (Fc epsilon RI beta and Fc epsilon RI gamma) were more heavily phosphorylated.
T6 930-1054 Sentence denotes Furthermore, the time course of the phosphorylations with mAb AA4 was slower than that induced by Fc epsilon RI aggregation.
T7 1055-1305 Sentence denotes By immunofluorescence, the tyrosine-phosphorylated proteins after mAb AA4 stimulation were localized in patches at the cell membrane and in areas of cell-cell contact, whereas after Fc epsilon RI activation, there was a reticular cytoplasmic pattern.
T8 1306-1518 Sentence denotes There were no protein tyrosine phosphorylations either when Fc epsilon RI was saturated with IgE or when F(ab')2 fragments of mAb AA4 were used, although the F(ab')2 fragments still induced morphological changes.
T9 1519-1633 Sentence denotes There was also coprecipitation of the beta and gamma subunits of Fc epsilon RI with the anti-ganglioside antibody.
T10 1634-1760 Sentence denotes These data strongly suggest the involvement of Fc epsilon RI in the antiganglioside-induced protein tyrosine phosphorylations.
T11 1761-1934 Sentence denotes Moreover, phosphorylations of these proteins including the beta and gamma chains of Fc epsilon RI and activation of p53/56lyn and p72syk did not result in histamine release.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells.
T2 145-280 Sentence denotes The monoclonal antibody AA4 (mAb AA4) recognizes novel alpha-galactosyl derivatives of GD1b on rat basophilic leukemia (RBL-2H3) cells.
T3 281-372 Sentence denotes The binding of mAb AA4 induced protein tyrosine phosphorylations without histamine release.
T4 373-608 Sentence denotes Several of the same proteins including Fc epsilon RI beta, Fc epsilon RI gamma, p72syk, and phospholipase C-gamma 1 were tyrosine-phosphorylated by mAb AA4 binding and by the activation of the high affinity IgE receptor, Fc epsilon RI.
T5 609-929 Sentence denotes There was also activation of the p53/56lyn and p72syk protein-tyrosine kinases, but compared to direct Fc epsilon RI activation, mAb AA4 did not result in increased tyrosine phosphorylation of pp105-115 or pp125FAK, and the receptor subunits (Fc epsilon RI beta and Fc epsilon RI gamma) were more heavily phosphorylated.
T6 930-1054 Sentence denotes Furthermore, the time course of the phosphorylations with mAb AA4 was slower than that induced by Fc epsilon RI aggregation.
T7 1055-1305 Sentence denotes By immunofluorescence, the tyrosine-phosphorylated proteins after mAb AA4 stimulation were localized in patches at the cell membrane and in areas of cell-cell contact, whereas after Fc epsilon RI activation, there was a reticular cytoplasmic pattern.
T8 1306-1518 Sentence denotes There were no protein tyrosine phosphorylations either when Fc epsilon RI was saturated with IgE or when F(ab')2 fragments of mAb AA4 were used, although the F(ab')2 fragments still induced morphological changes.
T9 1519-1633 Sentence denotes There was also coprecipitation of the beta and gamma subunits of Fc epsilon RI with the anti-ganglioside antibody.
T10 1634-1760 Sentence denotes These data strongly suggest the involvement of Fc epsilon RI in the antiganglioside-induced protein tyrosine phosphorylations.
T11 1761-1934 Sentence denotes Moreover, phosphorylations of these proteins including the beta and gamma chains of Fc epsilon RI and activation of p53/56lyn and p72syk did not result in histamine release.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 232-236 Glycan denotes GD1b https://api.glycosmos.org/wurcs2image/latest/png/binary/G37184KW

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 41-44 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T2 169-172 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T3 178-181 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T4 232-236 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1b http://www.glycoepitope.jp/epitopes/EP0059
T5 300-303 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T6 525-528 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T7 742-745 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T8 992-995 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T9 1125-1128 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285
T10 1436-1439 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes AA4 http://www.glycoepitope.jp/epitopes/AN0285

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 114-117 OrganismTaxon denotes rat 10114|10116
T3 240-243 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1174-1187 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886
T2 1285-1296 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737