PubMed:8019555 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	67-87	DNA	denotes	sex-determining gene
T2	88-91	DNA	denotes	SRY
T3	118-121	DNA	denotes	SRY
T4	346-357	protein	denotes	SRY protein
T5	404-414	protein	denotes	C terminus
T6	422-441	protein	denotes	DNA binding protein
T7	504-531	protein	denotes	HMG box containing proteins
T8	617-620	DNA	denotes	SRY

Id	Subject	Object	Predicate	Lexical cue
S1	0-92	Sentence	denotes	Description and functional implications of a novel mutation in the sex-determining gene SRY.
S2	93-249	Sentence	denotes	The sex-determining gene SRY was screened for molecular alteration in an XY sex-reversed female by single-strand conformation polymorphism (SSCP) technique.
S3	250-358	Sentence	denotes	An A-to-G transition was detected which leads to an exchange of a tyrosine by a cysteine in the SRY protein.
S4	359-532	Sentence	denotes	The affected tyrosine residue located at the C terminus of the DNA binding protein is evolutionarily strongly conserved among the members of the HMG box containing proteins.
S5	533-649	Sentence	denotes	Using gel shift assay and peptide synthesis such a mutation is shown to abolish the SRY protein DNA binding ability.
S6	650-741	Sentence	denotes	The involvement of this particular amino acid in the binding specificity is also discussed.

Id	Subject	Object	Predicate	Lexical cue
C1	43-59	NP	denotes	a novel mutation
C2	63-91	NP	denotes	the sex-determining gene SRY
C3	93-121	NP	denotes	The sex-determining gene SRY
C4	250-270	NP	denotes	An A-to-G transition
C5	284-289	NP	denotes	which
C7	342-349	NP	denotes	the SRY
C6	342-357	NP	denotes	the SRY protein
C8	559-576	NP	denotes	peptide synthesis
C9	577-592	NP	denotes	such a mutation
C11	613-620	NP	denotes	the SRY
C10	613-628	NP	denotes	the SRY protein
C12	669-695	NP	denotes	this particular amino acid
R1	C3	C2	coref-ident	The sex-determining gene SRY,the sex-determining gene SRY
R2	C5	C4	coref-relat	which,An A-to-G transition
R3	C7	C3	coref-ident	the SRY,The sex-determining gene SRY
R4	C9	C1	coref-other	such a mutation,a novel mutation
R5	C11	C7	coref-ident	the SRY,the SRY
R6	C10	C6	coref-ident	the SRY protein,the SRY protein
R7	C12	C8	coref-ident	this particular amino acid,peptide synthesis

Id	Subject	Object	Predicate	Lexical cue
T1	45-59	other_name	denotes	novel mutation
T2	67-87	DNA_family_or_group	denotes	sex-determining gene
T3	88-91	DNA_domain_or_region	denotes	SRY
T4	118-121	DNA_domain_or_region	denotes	SRY
T5	139-159	other_name	denotes	molecular alteration
T6	166-188	multi_cell	denotes	XY sex-reversed female
T7	192-248	other_name	denotes	single-strand conformation polymorphism (SSCP) technique
T8	253-270	other_name	denotes	A-to-G transition
T9	316-324	amino_acid_monomer	denotes	tyrosine
T10	330-338	amino_acid_monomer	denotes	cysteine
T11	346-349	DNA_domain_or_region	denotes	SRY
T12	372-380	amino_acid_monomer	denotes	tyrosine
T13	404-414	protein_domain_or_region	denotes	C terminus
T14	422-441	protein_family_or_group	denotes	DNA binding protein
T15	504-531	protein_family_or_group	denotes	HMG box containing proteins
T16	539-554	other_name	denotes	gel shift assay
T17	559-576	other_name	denotes	peptide synthesis
T18	617-620	DNA_domain_or_region	denotes	SRY
T19	685-695	amino_acid_monomer	denotes	amino acid
T20	703-722	other_name	denotes	binding specificity