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PubMed:7998962 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-31 protein denotes nuclear NF-kappa B
T2 69-78 cell_type denotes monocytes
T3 84-109 protein denotes nuclear factor NF-kappa B
T4 143-163 protein denotes transcription factor
T5 185-199 DNA denotes cytokine genes
T6 204-226 protein denotes cell-surface receptors
T7 321-331 protein denotes NF-kappa B
T8 410-430 cell_line denotes human monocytic line
T9 431-441 cell_line denotes Mono Mac 6
T10 567-577 protein denotes NF-kappa B
T11 648-666 protein denotes nuclear NF-kappa B
T12 803-813 protein denotes NF-kappa B
T13 845-867 protein denotes LPS-induced NF-kappa B
T14 923-934 protein denotes p50 subunit
T15 938-948 protein denotes NF-kappa B
T16 1038-1060 protein denotes LPS-induced NF-kappa B
T17 1074-1102 protein denotes constitutive binding protein
T18 1159-1169 protein denotes NF-kappa B
T19 1199-1209 cell_line denotes cell lines
T20 1217-1234 cell_type denotes monocytic lineage
T21 1236-1240 cell_line denotes HL60
T22 1242-1246 cell_line denotes U937
T23 1248-1253 cell_line denotes THP-1
T24 1255-1265 cell_line denotes Mono Mac 1
T25 1270-1280 cell_line denotes Mono Mac 6
T26 1294-1308 cell_line denotes Molt 4 T cells
T27 1312-1327 cell_line denotes K562 stem cells
T28 1403-1413 protein denotes NF-kappa B
T29 1440-1457 cell_line denotes mature cell lines
T30 1505-1521 cell_line denotes Mono Mac 6 cells
T31 1579-1589 protein denotes NF-kappa B
T32 1667-1677 protein denotes NF-kappa B
T33 1698-1713 cell_type denotes blood monocytes
T34 1715-1734 cell_type denotes pleural macrophages
T35 1739-1759 cell_type denotes alveolar macrophages
T36 1778-1788 protein denotes NF-kappa B
T37 1845-1884 RNA denotes tumour necrosis factor (TNF) transcript
T38 1902-1911 cell_type denotes monocytes
T39 2027-2037 protein denotes NF-kappa B
T40 2113-2131 cell_type denotes mature macrophages
T41 2146-2156 protein denotes NF-kappa B
T42 2199-2208 protein denotes cytokines
T43 2209-2212 protein denotes TNF
T44 2214-2227 protein denotes interleukin 6
T45 2229-2240 protein denotes interleukin
T46 2245-2293 protein denotes granulocyte-macrophage colony-stimulating factor
T47 2297-2333 protein denotes macrophage colony-stimulating factor
T48 2510-2520 protein denotes NF-kappa B

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-65 Sentence denotes Constitutive nuclear NF-kappa B in cells of the monocyte lineage.
S2 66-281 Sentence denotes In monocytes, the nuclear factor NF-kappa B has been invoked as an important transcription factor in the expression of cytokine genes, of cell-surface receptors and in the expression of human immunodeficiency virus.
S3 282-380 Sentence denotes In such cells, DNA binding activity of NF-kappa B can be detected without intentional stimulation.
S4 381-642 Sentence denotes In our studies, cells of the human monocytic line Mono Mac 6, cultured in medium containing fetal-calf serum and low levels of lipopolysaccharide (LPS), also exhibit such 'constitutive' NF-kappa B, as demonstrated by mobility-shift analysis of nuclear extracts.
S5 643-764 Sentence denotes This nuclear NF-kappa B was still present when contaminant LPS was removed by ultrafiltration and when serum was omitted.
S6 765-949 Sentence denotes Protein-DNA complexes of constitutive NF-kappa B are similar in mobility to the LPS-induced NF-kappa B and both are recognized by an antibody specific to the p50 subunit of NF-kappa B.
S7 950-1103 Sentence denotes By contrast, treatment of cells with pyrrolidine dithiocarbamate (PDTC) will only block LPS-induced NF-kappa B, but not the constitutive binding protein.
S8 1104-1328 Sentence denotes Using LPS-free and serum-free conditions, constitutive NF-kappa B can be detected in different cell lines of the monocytic lineage (HL60, U937, THP-1, Mono Mac 1 and Mono Mac 6), but not in Molt 4 T cells or K562 stem cells.
S9 1329-1458 Sentence denotes When ordered according to stage of maturation, the amount of constitutive NF-kappa B was not increased in more mature cell lines.
S10 1459-1606 Sentence denotes Furthermore, when inducing differentiation in Mono Mac 6 cells, with vitamin D3, no change in constitutive or inducible NF-kappa B can be detected.
S11 1607-1760 Sentence denotes Analysis of primary cells revealed substantial constitutive NF-kappa B-binding activity in blood monocytes, pleural macrophages and alveolar macrophages.
S12 1761-2000 Sentence denotes The constitutive NF-kappa B appears to be functionally active, since a low level of tumour necrosis factor (TNF) transcript is detectable in monocytes, and this level can be increased by blocking transcript degradation using cycloheximide.
S13 2001-2132 Sentence denotes The level of constitutive NF-kappa B in these cells is variable and is frequently found to be lower in the more mature macrophages.
S14 2133-2414 Sentence denotes Constitutive NF-kappa B was not maintained by autocrine action of cytokines TNF, interleukin 6, interleukin 10, granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor, since neutralizing antibodies did not reduce constitutive DNA-binding activity.
S15 2415-2521 Sentence denotes Furthermore, blockade of prostaglandin or leukotriene biosynthesis did not affect constitutive NF-kappa B.
S16 2521-2554 Sentence denotes (ABSTRACT TRUNCATED AT 400 WORDS)

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-31 NP denotes Constitutive nuclear NF-kappa B
C2 69-78 NP denotes monocytes
C3 80-109 NP denotes the nuclear factor NF-kappa B
C4 285-295 NP denotes such cells
C5 321-331 NP denotes NF-kappa B
C6 508-532 NP denotes lipopolysaccharide (LPS)
C7 552-577 NP denotes 'constitutive' NF-kappa B
C8 643-666 NP denotes This nuclear NF-kappa B
C9 690-705 NP denotes contaminant LPS
C10 790-813 NP denotes constitutive NF-kappa B
C11 841-867 NP denotes the LPS-induced NF-kappa B
C12 938-948 NP denotes NF-kappa B
C13 1038-1060 NP denotes LPS-induced NF-kappa B
C14 1070-1102 NP denotes the constitutive binding protein
C15 1146-1169 NP denotes constitutive NF-kappa B
C16 1390-1413 NP denotes constitutive NF-kappa B
C17 1761-1788 NP denotes The constitutive NF-kappa B
C18 1830-1884 NP denotes a low level of tumour necrosis factor (TNF) transcript
C19 1902-1911 NP denotes monocytes
C20 1917-1927 NP denotes this level
C21 1986-1999 NP denotes cycloheximide
C22 2014-2037 NP denotes constitutive NF-kappa B
C23 2041-2052 NP denotes these cells
C24 2133-2156 NP denotes Constitutive NF-kappa B
C25 2497-2520 NP denotes constitutive NF-kappa B
R1 C4 C2 coref-ident such cells,monocytes
R2 C5 C3 coref-ident NF-kappa B,the nuclear factor NF-kappa B
R3 C7 C1 coref-ident 'constitutive' NF-kappa B,Constitutive nuclear NF-kappa B
R4 C8 C7 coref-ident This nuclear NF-kappa B,'constitutive' NF-kappa B
R5 C9 C6 coref-ident contaminant LPS,lipopolysaccharide (LPS)
R6 C10 C7 coref-ident constitutive NF-kappa B,'constitutive' NF-kappa B
R7 C12 C5 coref-ident NF-kappa B,NF-kappa B
R8 C13 C11 coref-ident LPS-induced NF-kappa B,the LPS-induced NF-kappa B
R9 C14 C10 coref-ident the constitutive binding protein,constitutive NF-kappa B
R10 C15 C10 coref-ident constitutive NF-kappa B,constitutive NF-kappa B
R11 C16 C15 coref-ident constitutive NF-kappa B,constitutive NF-kappa B
R12 C17 C16 coref-ident The constitutive NF-kappa B,constitutive NF-kappa B
R13 C19 C2 coref-ident monocytes,monocytes
R14 C20 C18 coref-ident this level,a low level of tumour necrosis factor (TNF) transcript
R15 C22 C17 coref-ident constitutive NF-kappa B,The constitutive NF-kappa B
R16 C23 C21 coref-ident these cells,cycloheximide
R17 C24 C22 coref-ident Constitutive NF-kappa B,constitutive NF-kappa B
R18 C25 C24 coref-ident constitutive NF-kappa B,Constitutive NF-kappa B

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-31 protein_molecule denotes nuclear NF-kappa B
T2 69-78 cell_type denotes monocytes
T3 84-98 protein_molecule denotes nuclear factor
T4 99-109 protein_molecule denotes NF-kappa B
T5 143-163 protein_family_or_group denotes transcription factor
T6 185-199 DNA_family_or_group denotes cytokine genes
T7 204-226 protein_family_or_group denotes cell-surface receptors
T8 252-280 virus denotes human immunodeficiency virus
T9 297-317 other_name denotes DNA binding activity
T10 321-331 protein_molecule denotes NF-kappa B
T11 410-430 cell_line denotes human monocytic line
T12 431-441 cell_line denotes Mono Mac 6
T13 473-489 tissue denotes fetal-calf serum
T14 508-526 lipid denotes lipopolysaccharide
T15 528-531 lipid denotes LPS
T16 567-577 protein_molecule denotes NF-kappa B
T17 625-641 cell_component denotes nuclear extracts
T18 648-655 protein_molecule denotes nuclear
T19 656-666 protein_molecule denotes NF-kappa B
T20 702-705 lipid denotes LPS
T21 721-736 other_name denotes ultrafiltration
T22 746-751 tissue denotes serum
T23 803-813 protein_molecule denotes NF-kappa B
T24 845-848 lipid denotes LPS
T25 857-867 protein_molecule denotes NF-kappa B
T26 923-934 protein_subunit denotes p50 subunit
T27 938-948 protein_molecule denotes NF-kappa B
T28 987-1014 other_organic_compound denotes pyrrolidine dithiocarbamate
T29 1016-1020 other_organic_compound denotes PDTC
T30 1038-1041 lipid denotes LPS
T31 1050-1060 protein_molecule denotes NF-kappa B
T32 1074-1102 protein_family_or_group denotes constitutive binding protein
T33 1159-1169 protein_molecule denotes NF-kappa B
T34 1199-1209 cell_line denotes cell lines
T35 1217-1234 cell_type denotes monocytic lineage
T36 1236-1240 cell_line denotes HL60
T37 1242-1246 cell_line denotes U937
T38 1248-1253 cell_line denotes THP-1
T39 1255-1265 cell_line denotes Mono Mac 1
T40 1270-1280 cell_line denotes Mono Mac 6
T41 1294-1308 cell_line denotes Molt 4 T cells
T42 1312-1327 cell_line denotes K562 stem cells
T43 1403-1413 protein_molecule denotes NF-kappa B
T44 1440-1457 cell_line denotes mature cell lines
T45 1505-1521 cell_line denotes Mono Mac 6 cells
T46 1528-1538 lipid denotes vitamin D3
T47 1579-1589 protein_molecule denotes NF-kappa B
T48 1667-1677 protein_molecule denotes NF-kappa B
T49 1698-1703 cell_type denotes blood
T50 1704-1713 cell_type denotes monocytes
T51 1715-1734 cell_type denotes pleural macrophages
T52 1739-1759 cell_type denotes alveolar macrophages
T53 1778-1788 protein_molecule denotes NF-kappa B
T54 1845-1884 RNA_molecule denotes tumour necrosis factor (TNF) transcript
T55 1902-1911 cell_type denotes monocytes
T56 1986-1999 other_organic_compound denotes cycloheximide
T57 2027-2037 protein_molecule denotes NF-kappa B
T58 2113-2131 cell_type denotes mature macrophages
T59 2146-2156 protein_molecule denotes NF-kappa B
T60 2199-2208 protein_family_or_group denotes cytokines
T61 2209-2212 protein_family_or_group denotes TNF
T62 2214-2227 protein_molecule denotes interleukin 6
T63 2229-2240 protein_molecule denotes interleukin
T64 2245-2293 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T65 2297-2333 protein_molecule denotes macrophage colony-stimulating factor
T66 2393-2413 other_name denotes DNA-binding activity
T67 2440-2453 other_name denotes prostaglandin
T68 2457-2468 other_organic_compound denotes leukotriene
T69 2510-2520 protein_molecule denotes NF-kappa B