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sentences

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.
T2 93-265 Sentence denotes The tumor necrosis factor-alpha (TNF alpha) gene is an immediate early gene in activated T cells, in that it is rapidly induced without a requirement for protein synthesis.
T3 266-441 Sentence denotes Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin-dependent process that is blocked by cyclosporin A.
T4 442-619 Sentence denotes We have previously identified a promoter element, kappa 3, that is required for calcium-stimulated, cyclosporin A-sensitive induction of the TNF alpha gene in activated T cells.
T5 620-779 Sentence denotes Here, we demonstrate that the kappa 3 binding factor contains NFATp, a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription.
T6 780-902 Sentence denotes NFATp binds to two sites within the kappa 3 element, and occupancy of both sites is required for TNF alpha gene induction.
T7 903-1116 Sentence denotes Thus, although the kappa 3 element has little sequence similarity to other NFATp-binding sites, it appears to function as a cyclosporin-sensitive promoter element in T cells by virtue of its ability to bind NFATp.
T8 1117-1377 Sentence denotes The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation.
T1 0-92 Sentence denotes The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.
T2 93-265 Sentence denotes The tumor necrosis factor-alpha (TNF alpha) gene is an immediate early gene in activated T cells, in that it is rapidly induced without a requirement for protein synthesis.
T3 266-441 Sentence denotes Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin-dependent process that is blocked by cyclosporin A.
T4 442-619 Sentence denotes We have previously identified a promoter element, kappa 3, that is required for calcium-stimulated, cyclosporin A-sensitive induction of the TNF alpha gene in activated T cells.
T5 620-779 Sentence denotes Here, we demonstrate that the kappa 3 binding factor contains NFATp, a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription.
T6 780-902 Sentence denotes NFATp binds to two sites within the kappa 3 element, and occupancy of both sites is required for TNF alpha gene induction.
T7 903-1116 Sentence denotes Thus, although the kappa 3 element has little sequence similarity to other NFATp-binding sites, it appears to function as a cyclosporin-sensitive promoter element in T cells by virtue of its ability to bind NFATp.
T8 1117-1377 Sentence denotes The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 12-17 protein denotes NFATp
T2 21-77 DNA denotes cyclosporin A-sensitive tumor necrosis factor-alpha gene
T3 97-141 DNA denotes tumor necrosis factor-alpha (TNF alpha) gene
T4 182-189 cell_type denotes T cells
T5 287-301 RNA denotes TNF alpha mRNA
T6 333-340 cell_type denotes T cells
T7 378-389 protein denotes calcineurin
T8 474-490 DNA denotes promoter element
T9 492-499 DNA denotes kappa 3
T10 583-597 DNA denotes TNF alpha gene
T11 611-618 cell_type denotes T cells
T12 650-672 protein denotes kappa 3 binding factor
T13 682-687 protein denotes NFATp
T14 691-732 protein denotes cyclosporin-sensitive DNA-binding protein
T15 746-764 DNA denotes interleukin-2 gene
T16 780-785 protein denotes NFATp
T17 816-831 DNA denotes kappa 3 element
T18 877-880 protein denotes TNF
T19 922-937 DNA denotes kappa 3 element
T20 978-997 DNA denotes NFATp-binding sites
T21 1027-1065 DNA denotes cyclosporin-sensitive promoter element
T22 1069-1076 cell_type denotes T cells
T23 1110-1115 protein denotes NFATp
T24 1136-1141 protein denotes NFATp
T25 1184-1197 protein denotes interleukin-2
T26 1202-1217 DNA denotes TNF alpha genes
T27 1308-1322 DNA denotes cytokine genes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 12-17 NP denotes NFATp
C2 93-141 NP denotes The tumor necrosis factor-alpha (TNF alpha) gene
C3 145-189 NP denotes an immediate early gene in activated T cells
C4 194-198 NP denotes that
C5 199-201 NP denotes it
C6 333-340 NP denotes T cells
C7 376-407 NP denotes a calcineurin-dependent process
C8 408-412 NP denotes that
C9 472-490 NP denotes a promoter element
C10 492-499 NP denotes kappa 3
C11 501-505 NP denotes that
C13 579-597 NP denotes the TNF alpha gene
C12 579-618 NP denotes the TNF alpha gene in activated T cells
C14 682-687 NP denotes NFATp
C15 689-778 NP denotes a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription
C16 780-785 NP denotes NFATp
C18 812-831 NP denotes the kappa 3 element
C17 795-831 NP denotes two sites within the kappa 3 element
C19 850-860 NP denotes both sites
C20 918-937 NP denotes the kappa 3 element
C21 999-1001 NP denotes it
C22 1069-1076 NP denotes T cells
C23 1090-1093 NP denotes its
C24 1110-1115 NP denotes NFATp
C25 1136-1141 NP denotes NFATp
C26 1232-1243 NP denotes this factor
R1 C4 C3 coref-relat that,an immediate early gene in activated T cells
R2 C5 C2 coref-pron it,The tumor necrosis factor-alpha (TNF alpha) gene
R3 C8 C7 coref-relat that,a calcineurin-dependent process
R4 C10 C9 coref-appos kappa 3,a promoter element
R5 C11 C9 coref-relat that,a promoter element
R6 C13 C12 coref-ident the TNF alpha gene,the TNF alpha gene in activated T cells
R7 C12 C2 coref-ident the TNF alpha gene in activated T cells,The tumor necrosis factor-alpha (TNF alpha) gene
R8 C14 C1 coref-ident NFATp,NFATp
R9 C15 C14 coref-appos a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription,NFATp
R10 C16 C14 coref-ident NFATp,NFATp
R11 C18 C9 coref-ident the kappa 3 element,a promoter element
R12 C19 C17 coref-ident both sites,two sites within the kappa 3 element
R13 C20 C18 coref-ident the kappa 3 element,the kappa 3 element
R14 C21 C20 coref-pron it,the kappa 3 element
R15 C22 C6 coref-ident T cells,T cells
R16 C23 C20 coref-pron its,the kappa 3 element
R17 C24 C16 coref-ident NFATp,NFATp
R18 C25 C24 coref-ident NFATp,NFATp
R19 C26 C25 coref-ident this factor,NFATp

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-92 Sentence denotes The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.
S2 93-265 Sentence denotes The tumor necrosis factor-alpha (TNF alpha) gene is an immediate early gene in activated T cells, in that it is rapidly induced without a requirement for protein synthesis.
S3 266-441 Sentence denotes Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin-dependent process that is blocked by cyclosporin A.
S4 442-619 Sentence denotes We have previously identified a promoter element, kappa 3, that is required for calcium-stimulated, cyclosporin A-sensitive induction of the TNF alpha gene in activated T cells.
S5 620-779 Sentence denotes Here, we demonstrate that the kappa 3 binding factor contains NFATp, a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription.
S6 780-902 Sentence denotes NFATp binds to two sites within the kappa 3 element, and occupancy of both sites is required for TNF alpha gene induction.
S7 903-1116 Sentence denotes Thus, although the kappa 3 element has little sequence similarity to other NFATp-binding sites, it appears to function as a cyclosporin-sensitive promoter element in T cells by virtue of its ability to bind NFATp.
S8 1117-1377 Sentence denotes The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-17 protein_molecule denotes NFATp
T2 21-66 protein_molecule denotes cyclosporin A-sensitive tumor necrosis factor
T3 97-124 protein_molecule denotes tumor necrosis factor-alpha
T4 126-129 protein_molecule denotes TNF
T5 182-189 cell_type denotes T cells
T6 247-264 other_name denotes protein synthesis
T7 287-290 protein_molecule denotes TNF
T8 333-340 cell_type denotes T cells
T9 346-364 other_organic_compound denotes calcium ionophores
T10 378-389 protein_molecule denotes calcineurin
T11 427-440 other_organic_compound denotes cyclosporin A
T12 474-490 DNA_domain_or_region denotes promoter element
T13 492-499 DNA_domain_or_region denotes kappa 3
T14 542-555 other_organic_compound denotes cyclosporin A
T15 583-586 protein_molecule denotes TNF
T16 611-618 cell_type denotes T cells
T17 650-657 DNA_domain_or_region denotes kappa 3
T18 682-687 protein_molecule denotes NFATp
T19 691-732 protein_family_or_group denotes cyclosporin-sensitive DNA-binding protein
T20 746-764 DNA_domain_or_region denotes interleukin-2 gene
T21 780-785 protein_molecule denotes NFATp
T22 816-823 DNA_domain_or_region denotes kappa 3
T23 877-880 protein_molecule denotes TNF
T24 922-929 DNA_domain_or_region denotes kappa 3
T25 978-983 protein_molecule denotes NFATp
T26 1027-1048 DNA_domain_or_region denotes cyclosporin-sensitive
T27 1049-1065 DNA_domain_or_region denotes promoter element
T28 1069-1076 cell_type denotes T cells
T29 1110-1115 protein_molecule denotes NFATp
T30 1136-1141 protein_molecule denotes NFATp
T31 1145-1171 other_name denotes transcriptional activation
T32 1184-1197 protein_molecule denotes interleukin-2
T33 1202-1211 protein_family_or_group denotes TNF alpha
T34 1308-1322 DNA_family_or_group denotes cytokine genes
T35 1359-1376 other_name denotes T cell activation

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 45-50 Phenotype denotes tumor HP:0002664
T2 97-102 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 45-50 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 97-102 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1359-1365 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 182-189 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 333-340 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 611-618 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 1069-1076 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 1359-1365 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084