PubMed:7971441 JSONTXT

{"project":"PennBioIE","denotations":[{"id":"T1","span":{"begin":66,"end":78},"obj":"protein"},{"id":"T2","span":{"begin":82,"end":90},"obj":"protein"},{"id":"T3","span":{"begin":327,"end":336},"obj":"protein"},{"id":"T4","span":{"begin":337,"end":343},"obj":"protein"},{"id":"T5","span":{"begin":357,"end":362},"obj":"protein"},{"id":"T6","span":{"begin":415,"end":429},"obj":"protein"},{"id":"T7","span":{"begin":431,"end":444},"obj":"protein"},{"id":"T8","span":{"begin":446,"end":458},"obj":"protein"},{"id":"T9","span":{"begin":464,"end":480},"obj":"protein"},{"id":"T10","span":{"begin":481,"end":503},"obj":"protein"},{"id":"T11","span":{"begin":793,"end":802},"obj":"protein"},{"id":"T12","span":{"begin":803,"end":815},"obj":"protein"}],"text":"[Oncogenes and suppressor genes in the genesis and progression of solid tumors in children].\nOncogeni e geni soppressori nella genesi e nella progressione dei tumori solidi del bambino.\nMolecular and genetic analyses of tumor cell show that cellular oncogenes and suppressor genes are involved in neoplastic transformation. In pediatric tumors oncogenes as N-myc play an important role in the tumor progression. In retinoblastoma, neuroblastoma, Wilms' tumor, and rhabdomyosarcoma loss of heterozygosity for specific chromosome loci has been suggested to be a critical step in cancer development. Oncogene abnormalities can also be useful as a molecular tumor factor to foresee the prognosis of the disease. The present article is a review on the role of the oncogenes and suppressor genes in pediatric solid tumors."}