PubMed:7964516 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	11-30	protein	denotes	Myc-Max heterodimer
T2	79-96	cell_line	denotes	T cell hybridomas
T3	98-115	cell_line	denotes	T cell hybridomas
T4	266-293	cell_type	denotes	immature and mature T cells
T5	368-381	protein	denotes	c-Myc protein
T6	447-452	protein	denotes	c-Myc
T7	563-566	protein	denotes	Max
T8	653-684	protein	denotes	reciprocally mutant Myc protein
T9	715-727	protein	denotes	heterodimers
T10	744-747	protein	denotes	Max
T11	865-868	protein	denotes	Myc
T12	945-948	protein	denotes	Max

Id	Subject	Object	Predicate	Lexical cue
C1	47-75	NP	denotes	activation-induced apoptosis
C2	79-96	NP	denotes	T cell hybridomas
C3	98-115	NP	denotes	T cell hybridomas
C4	364-381	NP	denotes	the c-Myc protein
C5	403-431	NP	denotes	activation-induced apoptosis
C6	447-452	NP	denotes	c-Myc
C8	528-531	NP	denotes	its
C7	528-561	NP	denotes	its heterodimeric binding partner
C9	563-566	NP	denotes	Max
C10	568-573	NP	denotes	which
C11	596-624	NP	denotes	activation-induced apoptosis
C12	733-747	NP	denotes	the mutant Max
C13	810-838	NP	denotes	activation-induced apoptosis
C14	865-868	NP	denotes	Myc
C15	878-906	NP	denotes	activation-induced apoptosis
C16	945-948	NP	denotes	Max
R1	C3	C2	coref-ident	T cell hybridomas,T cell hybridomas
R2	C5	C1	coref-ident	activation-induced apoptosis,activation-induced apoptosis
R3	C6	C4	coref-ident	c-Myc,the c-Myc protein
R4	C8	C6	coref-pron	its,c-Myc
R5	C9	C7	coref-appos	Max,its heterodimeric binding partner
R6	C10	C7	coref-relat	which,its heterodimeric binding partner
R7	C11	C5	coref-ident	activation-induced apoptosis,activation-induced apoptosis
R8	C12	C9	coref-ident	the mutant Max,Max
R9	C13	C11	coref-ident	activation-induced apoptosis,activation-induced apoptosis
R10	C14	C6	coref-ident	Myc,c-Myc
R11	C15	C13	coref-ident	activation-induced apoptosis,activation-induced apoptosis
R12	C16	C12	coref-ident	Max,the mutant Max

Id	Subject	Object	Predicate	Lexical cue
S1	0-97	Sentence	denotes	Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.
S2	98-302	Sentence	denotes	T cell hybridomas respond to activation signals by undergoing apoptotic cell death, and this is likely to represent comparable events related to tolerance induction in immature and mature T cells in vivo.
S3	303-432	Sentence	denotes	Previous studies using antisense oligonucleotides implicated the c-Myc protein in the phenomenon of activation-induced apoptosis.
S4	433-625	Sentence	denotes	This role for c-Myc in apoptosis is now confirmed in studies using a dominant negative form of its heterodimeric binding partner, Max, which we show here inhibits activation-induced apoptosis.
S5	626-839	Sentence	denotes	Further, coexpression of a reciprocally mutant Myc protein capable of forming functional heterodimers with the mutant Max can compensate for the dominant negative activity and restore activation-induced apoptosis.
S6	840-998	Sentence	denotes	These results imply that Myc promotes activation-induced apoptosis by obligatory heterodimerization with Max, and therefore, by regulating gene transcription.

Id	Subject	Object	Predicate	Lexical cue
T1	11-30	protein_complex	denotes	Myc-Max heterodimer
T2	66-75	other_name	denotes	apoptosis
T3	79-96	cell_line	denotes	T cell hybridomas
T4	98-115	cell_line	denotes	T cell hybridomas
T5	127-145	other_name	denotes	activation signals
T6	160-180	other_name	denotes	apoptotic cell death
T7	326-352	polynucleotide	denotes	antisense oligonucleotides
T8	368-381	protein_molecule	denotes	c-Myc protein
T9	422-431	other_name	denotes	apoptosis
T10	447-452	protein_molecule	denotes	c-Myc
T11	456-465	other_name	denotes	apoptosis
T12	563-566	protein_molecule	denotes	Max
T13	615-624	other_name	denotes	apoptosis
T14	653-684	protein_molecule	denotes	reciprocally mutant Myc protein
T15	715-727	protein_complex	denotes	heterodimers
T16	744-747	protein_molecule	denotes	Max
T17	771-797	other_name	denotes	dominant negative activity
T18	829-838	other_name	denotes	apoptosis
T19	865-868	protein_molecule	denotes	Myc
T20	897-906	other_name	denotes	apoptosis
T21	910-939	other_name	denotes	obligatory heterodimerization
T22	945-948	protein_molecule	denotes	Max
T23	979-997	other_name	denotes	gene transcription