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PubMed:7927950 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-89 Sentence denotes EGF modulation of the ras-related rhoB gene expression in human breast-cancer cell lines.
TextSentencer_T2 90-328 Sentence denotes The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization.
TextSentencer_T3 329-460 Sentence denotes In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations in the mRNA level of the rhoB gene were evidenced.
TextSentencer_T4 461-593 Sentence denotes The rhoB mRNA level appeared to be inversely correlated to the amounts of the epidermal-growth-factor(EGF) receptors in these cells.
TextSentencer_T5 594-850 Sentence denotes The rhoB transcripts were detected at high levels in ZR75-1, MCF7, HSL 53, HSL 59, HSL 90, T47D and SKBR3 HBCal, at hardly detectable levels in BT 20, MDA-MB 231 and H466B HBCal and at intermediate levels in normal and immortalized breast epithelial cells.
TextSentencer_T6 851-1008 Sentence denotes Rapid and transient induction of the rhoB transcription was observed after EGF treatment in serum-deprived MDA-MB231, T47D and immortalized epithelial cells.
TextSentencer_T7 1009-1117 Sentence denotes In contrast, no modulation of rhoB expression by EGF could be objectified in the MCF7 and ZR75-1 cell lines.
TextSentencer_T8 1118-1327 Sentence denotes Yet a normal function of EGF receptors was evidenced, since the immediate early gene c-fos was rapidly induced, suggesting a constitutive expression of rhoB in these cell lines bypassing the regulation by EGF.
TextSentencer_T9 1328-1470 Sentence denotes In human mammary epithelial cells, rhoB mRNA is rapidly and transiently induced with EGF concentrations known to stimulate cell proliferation.
TextSentencer_T10 1471-1672 Sentence denotes This suggests that the rhoB product might be involved in a cascade that initiates or promotes cell proliferation, and plays an important role in EGF-stimulated growth of breast normal and cancer cells.
T1 0-89 Sentence denotes EGF modulation of the ras-related rhoB gene expression in human breast-cancer cell lines.
T2 90-328 Sentence denotes The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization.
T3 329-460 Sentence denotes In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations in the mRNA level of the rhoB gene were evidenced.
T4 461-593 Sentence denotes The rhoB mRNA level appeared to be inversely correlated to the amounts of the epidermal-growth-factor(EGF) receptors in these cells.
T5 594-850 Sentence denotes The rhoB transcripts were detected at high levels in ZR75-1, MCF7, HSL 53, HSL 59, HSL 90, T47D and SKBR3 HBCal, at hardly detectable levels in BT 20, MDA-MB 231 and H466B HBCal and at intermediate levels in normal and immortalized breast epithelial cells.
T6 851-1008 Sentence denotes Rapid and transient induction of the rhoB transcription was observed after EGF treatment in serum-deprived MDA-MB231, T47D and immortalized epithelial cells.
T7 1009-1117 Sentence denotes In contrast, no modulation of rhoB expression by EGF could be objectified in the MCF7 and ZR75-1 cell lines.
T8 1118-1327 Sentence denotes Yet a normal function of EGF receptors was evidenced, since the immediate early gene c-fos was rapidly induced, suggesting a constitutive expression of rhoB in these cell lines bypassing the regulation by EGF.
T9 1328-1470 Sentence denotes In human mammary epithelial cells, rhoB mRNA is rapidly and transiently induced with EGF concentrations known to stimulate cell proliferation.
T10 1471-1672 Sentence denotes This suggests that the rhoB product might be involved in a cascade that initiates or promotes cell proliferation, and plays an important role in EGF-stimulated growth of breast normal and cancer cells.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 34-38 gene:388 denotes rhoB
T1 64-77 disease:C0006142 denotes breast-cancer
T2 34-38 gene:388 denotes rhoB
T3 64-77 disease:C0678222 denotes breast-cancer
R1 T0 T1 associated_with rhoB,breast-cancer
R2 T2 T3 associated_with rhoB,breast-cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T976 34-38 gene:388 denotes rhoB
T977 64-77 disease:C0006142 denotes breast-cancer
R1 T976 T977 associated_with rhoB,breast-cancer
R2 T976 T977 associated_with rhoB,breast-cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 64-70 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 179-185 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 826-832 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 1641-1647 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 943-948 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 943-948 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 64-70 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 179-185 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 826-832 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1641-1647 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 826-843 http://purl.obolibrary.org/obo/UBERON_0008367 denotes breast epithelial