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PubMed:7927175 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-50 protein denotes retinoic acid receptor alpha
T2 58-70 cell_type denotes myeloid cell
T3 334-346 protein denotes RA receptors
T4 348-352 protein denotes RARs
T5 355-359 protein denotes RARs
T6 379-423 protein denotes steroid/thyroid hormone receptor superfamily
T7 496-523 protein denotes RA (ligand)-binding domains
T8 557-561 protein denotes RARs
T9 577-586 protein denotes RAR alpha
T10 651-676 cell_type denotes hematopoietic progenitors
T11 722-726 protein denotes RARs
T12 826-835 protein denotes RAR alpha
T13 900-915 protein denotes human RAR alpha
T14 917-927 protein denotes hRAR alpha
T15 934-958 cell_type denotes murine bone marrow cells
T16 1016-1037 DNA denotes drug resistant marker
T17 1039-1045 DNA denotes Neo(r)
T18 1063-1079 cell_line denotes stroma cell line
T19 1081-1088 cell_line denotes PA6-neo
T20 1120-1134 cell_type denotes infected cells
T21 1198-1208 protein denotes hRAR alpha
T22 1219-1243 cell_type denotes promyelocytic morphology
T23 1355-1369 cell_type denotes immature cells
T24 1451-1460 protein denotes RAR alpha
T25 1461-1475 cell_type denotes infected cells
T26 1513-1531 cell_type denotes mature macrophages
T27 1569-1579 cell_line denotes IL3 colony
T28 1634-1643 protein denotes RAR alpha
T29 1675-1687 cell_type denotes myeloid cell
T30 1708-1717 protein denotes RAR alpha
T31 1862-1877 DNA denotes essential genes
T32 1901-1925 cell_type denotes normal bone marrow cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 22-50 NP denotes retinoic acid receptor alpha
C1 1-50 NP denotes An overexpression of retinoic acid receptor alpha
C3 58-86 NP denotes myeloid cell differentiation
C4 90-112 NP denotes the promyelocyte stage
C5 115-133 NP denotes Retinoic acid (RA)
C6 135-157 NP denotes a vitamin A derivative
C7 279-281 NP denotes RA
C8 326-353 NP denotes nuclear RA receptors (RARs)
C9 355-359 NP denotes RARs
C10 436-457 NP denotes a molecular structure
C11 458-462 NP denotes that
C12 550-561 NP denotes RA and RARs
C13 577-586 NP denotes RAR alpha
C14 715-726 NP denotes RA and RARs
C15 819-821 NP denotes RA
C16 826-835 NP denotes RAR alpha
C17 900-928 NP denotes human RAR alpha (hRAR alpha)
C18 934-981 NP denotes murine bone marrow cells with retroviral vector
C19 987-1010 NP denotes selected infected cells
C20 1120-1134 NP denotes infected cells
C21 1173-1183 NP denotes Most cells
C22 1198-1208 NP denotes hRAR alpha
C23 1278-1301 NP denotes the promyelocytic stage
C24 1305-1310 NP denotes their
C25 1349-1369 NP denotes these immature cells
C26 1451-1475 NP denotes RAR alpha infected cells
C28 1634-1649 NP denotes RAR alpha alone
C27 1613-1649 NP denotes an overexpression of RAR alpha alone
C29 1675-1703 NP denotes myeloid cell differentiation
C30 1708-1717 NP denotes RAR alpha
R1 C6 C5 coref-appos a vitamin A derivative,Retinoic acid (RA)
R2 C7 C5 coref-ident RA,Retinoic acid (RA)
R3 C9 C8 coref-ident RARs,nuclear RA receptors (RARs)
R4 C11 C10 coref-relat that,a molecular structure
R5 C13 C2 coref-ident RAR alpha,retinoic acid receptor alpha
R6 C14 C12 coref-ident RA and RARs,RA and RARs
R7 C15 C7 coref-ident RA,RA
R8 C16 C13 coref-ident RAR alpha,RAR alpha
R9 C20 C19 coref-ident infected cells,selected infected cells
R10 C21 C18 coref-ident Most cells,murine bone marrow cells with retroviral vector
R11 C22 C17 coref-ident hRAR alpha,human RAR alpha (hRAR alpha)
R12 C23 C4 coref-ident the promyelocytic stage,the promyelocyte stage
R13 C24 C21 coref-pron their,Most cells
R14 C25 C21 coref-ident these immature cells,Most cells
R15 C26 C25 coref-ident RAR alpha infected cells,these immature cells
R16 C28 C16 coref-ident RAR alpha alone,RAR alpha
R17 C27 C1 coref-ident an overexpression of RAR alpha alone,An overexpression of retinoic acid receptor alpha
R18 C29 C3 coref-ident myeloid cell differentiation,myeloid cell differentiation
R19 C30 C28 coref-ident RAR alpha,RAR alpha alone

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-113 Sentence denotes [An overexpression of retinoic acid receptor alpha blocks myeloid cell differentiation at the promyelocyte stage]
S2 115-251 Sentence denotes Retinoic acid (RA), a vitamin A derivative, exerts a wide range of biological effects related to cell proliferation and differentiation.
S3 252-354 Sentence denotes The pleiotropic effects of RA are thought to be mediated through specific nuclear RA receptors (RARs).
S4 355-524 Sentence denotes RARs are members of the steroid/thyroid hormone receptor superfamily and exhibit a molecular structure that possess discrete DNA-binding and RA (ligand)-binding domains.
S5 525-677 Sentence denotes In hematopoietic system, RA and RARs, predominantly RAR alpha may play key roles for the proliferation and differentiation of hematopoietic progenitors.
S6 678-791 Sentence denotes However, it is currently unknown how RA and RARs are involved in regulating normal hematopoietic differentiation.
S7 792-1135 Sentence denotes To make clear the roles of RA and RAR alpha in the normal hematopoiesis, I have introduced the construct of human RAR alpha (hRAR alpha) into murine bone marrow cells with retroviral vector, and selected infected cells with drug resistant marker (Neo(r)) cultured on the stroma cell line (PA6-neo), and analyzed the behavior of infected cells.
S8 1136-1172 Sentence denotes All of procedure were done in vitro.
S9 1173-1335 Sentence denotes Most cells infected with hRAR alpha exhibited promyelocytic morphology and were thought to be blocked at the promyelocytic stage in their myeloid differentiation.
S10 1336-1450 Sentence denotes Furthermore, these immature cells differentiated terminally into mature granulocytes by adding with RA (10(-6) M).
S11 1451-1580 Sentence denotes RAR alpha infected cells were also able to differentiate into mature macrophages in the both of long term culture and IL3 colony.
S12 1581-1793 Sentence denotes These observations suggest that an overexpression of RAR alpha alone is effective to suppress myeloid cell differentiation and RAR alpha plays a crucial role in the terminal differentiation of myeloid precursors.
S13 1794-1926 Sentence denotes The system described here may serve as a model for studying the the essential genes for differentiation of normal bone marrow cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 22-50 protein_molecule denotes retinoic acid receptor alpha
T2 58-70 cell_type denotes myeloid cell
T3 94-112 other_name denotes promyelocyte stage
T4 130-132 other_organic_compound denotes RA
T5 137-146 lipid denotes vitamin A
T6 212-230 other_name denotes cell proliferation
T7 235-250 other_name denotes differentiation
T8 256-275 other_name denotes pleiotropic effects
T9 279-281 other_organic_compound denotes RA
T10 334-336 other_organic_compound denotes RA
T11 348-352 protein_family_or_group denotes RARs
T12 355-359 protein_family_or_group denotes RARs
T13 379-423 protein_family_or_group denotes steroid/thyroid hormone receptor superfamily
T14 496-498 other_organic_compound denotes RA
T15 550-552 other_organic_compound denotes RA
T16 557-561 protein_family_or_group denotes RARs
T17 577-586 protein_molecule denotes RAR alpha
T18 632-647 other_name denotes differentiation
T19 651-676 cell_type denotes hematopoietic progenitors
T20 715-717 other_organic_compound denotes RA
T21 722-726 protein_family_or_group denotes RARs
T22 761-790 other_name denotes hematopoietic differentiation
T23 819-821 other_organic_compound denotes RA
T24 826-835 protein_molecule denotes RAR alpha
T25 850-863 other_name denotes hematopoiesis
T26 900-905 protein_molecule denotes human
T27 906-915 protein_molecule denotes RAR alpha
T28 917-927 protein_molecule denotes hRAR alpha
T29 934-940 cell_type denotes murine
T30 941-952 tissue denotes bone marrow
T31 964-981 virus denotes retroviral vector
T32 1016-1037 DNA_domain_or_region denotes drug resistant marker
T33 1039-1045 DNA_domain_or_region denotes Neo(r)
T34 1063-1079 cell_line denotes stroma cell line
T35 1081-1088 cell_line denotes PA6-neo
T36 1120-1134 cell_type denotes infected cells
T37 1198-1208 protein_molecule denotes hRAR alpha
T38 1219-1243 cell_type denotes promyelocytic morphology
T39 1311-1334 other_name denotes myeloid differentiation
T40 1355-1369 cell_type denotes immature cells
T41 1436-1438 other_organic_compound denotes RA
T42 1451-1460 protein_molecule denotes RAR alpha
T43 1461-1475 cell_type denotes infected cells
T44 1513-1531 cell_type denotes mature macrophages
T45 1569-1579 cell_line denotes IL3 colony
T46 1616-1630 other_name denotes overexpression
T47 1634-1643 protein_molecule denotes RAR alpha
T48 1675-1687 cell_type denotes myeloid cell
T49 1708-1717 protein_molecule denotes RAR alpha
T50 1746-1770 other_name denotes terminal differentiation
T51 1862-1877 DNA_family_or_group denotes essential genes
T52 1882-1897 other_name denotes differentiation
T53 1901-1907 cell_type denotes normal
T54 1908-1919 tissue denotes bone marrow