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PubMed:7925569 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-78 DNA denotes major histocompatibility complex class II DRA promoter
T2 105-126 protein denotes AIR-1 trans-activator
T3 128-136 cell_line denotes RJ 2.2.5
T4 142-161 cell_line denotes human B cell mutant
T5 179-205 cell_line denotes Burkitt lymphoma Raji cell
T6 351-404 DNA denotes major histocompatibility complex (MHC) class II genes
T7 431-438 protein denotes DNase I
T8 462-480 DNA denotes AIR-1 locus defect
T9 512-524 DNA denotes DRA promoter
T10 567-591 DNA denotes human MHC class II genes
T11 595-631 cell_line denotes RJ 2.2.5 x mouse spleen cell hybrids
T12 672-684 DNA denotes DRA promoter
T13 716-728 DNA denotes DRA promoter
T14 748-778 cell_line denotes class II-negative B cell lines
T15 883-891 cell_line denotes RJ 2.2.5
T16 896-906 cell_line denotes Raji cells
T17 933-940 protein denotes DNase I
T18 991-1011 cell_line denotes patients' cell lines
T19 1041-1054 DNA denotes bare promoter
T20 1146-1153 protein denotes DNase I
T21 1203-1221 DNA denotes AIR-1 locus defect
T22 1227-1244 DNA denotes class II promoter
T23 1375-1402 cell_line denotes MHC class II-negative cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 24-88 NP denotes major histocompatibility complex class II DRA promoter occupancy
C2 128-136 NP denotes RJ 2.2.5
C3 175-205 NP denotes the Burkitt lymphoma Raji cell
C4 206-211 NP denotes which
C5 228-252 NP denotes the AIR-1 locus function
C6 254-264 NP denotes This locus
C7 458-480 NP denotes the AIR-1 locus defect
C8 508-534 NP denotes the DRA promoter occupancy
C9 672-694 NP denotes DRA promoter occupancy
C10 716-738 NP denotes DRA promoter occupancy
C11 742-778 NP denotes other class II-negative B cell lines
C12 863-870 NP denotes the one
C13 883-891 NP denotes RJ 2.2.5
C14 896-906 NP denotes Raji cells
C15 918-940 NP denotes the use of the DNase I
C16 987-1011 NP denotes the patients' cell lines
C17 1135-1153 NP denotes the use of DNase I
C18 1199-1221 NP denotes the AIR-1 locus defect
C19 1227-1266 NP denotes class II promoter occupancy alterations
C20 1283-1300 NP denotes these alterations
C21 1306-1314 NP denotes the ones
R1 C4 C3 coref-relat which,the Burkitt lymphoma Raji cell
R2 C6 C5 coref-ident This locus,the AIR-1 locus function
R3 C8 C1 coref-ident the DRA promoter occupancy,major histocompatibility complex class II DRA promoter occupancy
R4 C9 C8 coref-ident DRA promoter occupancy,the DRA promoter occupancy
R5 C10 C9 coref-ident DRA promoter occupancy,DRA promoter occupancy
R6 C12 C10 coref-ident the one,DRA promoter occupancy
R7 C13 C2 coref-ident RJ 2.2.5,RJ 2.2.5
R8 C14 C3 coref-ident Raji cells,the Burkitt lymphoma Raji cell
R9 C16 C11 coref-ident the patients' cell lines,other class II-negative B cell lines
R10 C17 C15 coref-ident the use of DNase I,the use of the DNase I
R11 C18 C7 coref-ident the AIR-1 locus defect,the AIR-1 locus defect
R12 C20 C19 coref-ident these alterations,class II promoter occupancy alterations
R13 C21 C19 coref-ident the ones,class II promoter occupancy alterations

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-127 Sentence denotes In vivo modification of major histocompatibility complex class II DRA promoter occupancy mediated by the AIR-1 trans-activator.
S2 128-253 Sentence denotes RJ 2.2.5 is a human B cell mutant derived from the Burkitt lymphoma Raji cell which is defective in the AIR-1 locus function.
S3 254-405 Sentence denotes This locus encodes a transcriptional trans-activator required for the constitutive expression of major histocompatibility complex (MHC) class II genes.
S4 406-535 Sentence denotes Here we show, by in vivo DNase I footprinting, that the AIR-1 locus defect correlates with changes in the DRA promoter occupancy.
S5 536-715 Sentence denotes Interestingly, reexpression of human MHC class II genes in RJ 2.2.5 x mouse spleen cell hybrids is associated with partial reversion of DRA promoter occupancy to the Raji pattern.
S6 716-907 Sentence denotes DRA promoter occupancy in other class II-negative B cell lines, derived from patients with bare lymphocyte syndrome, is drastically different from the one observed in RJ 2.2.5 and Raji cells.
S7 908-1128 Sentence denotes Moreover, the use of the DNase I as an in vivo footprinting agent reveals that the patients' cell lines do not display a completely "bare promoter" as previously reported using dimethyl sulfate as the footprinting agent.
S8 1129-1403 Sentence denotes Thus, the use of DNase I allowed us, for the first time, to correlate the AIR-1 locus defect with class II promoter occupancy alterations and distinguish these alterations from the ones observed in phenotypically similar but genetically distinct MHC class II-negative cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 24-65 protein_complex denotes major histocompatibility complex class II
T2 105-126 protein_molecule denotes AIR-1 trans-activator
T3 128-136 cell_line denotes RJ 2.2.5
T4 142-161 cell_line denotes human B cell mutant
T5 179-205 cell_line denotes Burkitt lymphoma Raji cell
T6 232-252 atom denotes AIR-1 locus function
T7 324-347 other_name denotes constitutive expression
T8 351-404 DNA_family_or_group denotes major histocompatibility complex (MHC) class II genes
T9 423-430 other_name denotes in vivo
T10 431-438 protein_molecule denotes DNase I
T11 462-480 DNA_domain_or_region denotes AIR-1 locus defect
T12 512-524 DNA_domain_or_region denotes DRA promoter
T13 567-591 DNA_family_or_group denotes human MHC class II genes
T14 595-631 cell_line denotes RJ 2.2.5 x mouse spleen cell hybrids
T15 672-684 DNA_domain_or_region denotes DRA promoter
T16 702-714 other_name denotes Raji pattern
T17 716-728 DNA_domain_or_region denotes DRA promoter
T18 748-778 cell_line denotes class II-negative B cell lines
T19 793-801 multi_cell denotes patients
T20 807-831 other_name denotes bare lymphocyte syndrome
T21 883-891 cell_line denotes RJ 2.2.5
T22 896-906 cell_line denotes Raji cells
T23 933-940 protein_molecule denotes DNase I
T24 947-967 other_name denotes in vivo footprinting
T25 991-999 multi_cell denotes patients
T26 1041-1054 DNA_domain_or_region denotes bare promoter
T27 1085-1101 other_organic_compound denotes dimethyl sulfate
T28 1109-1127 other_name denotes footprinting agent
T29 1146-1153 protein_molecule denotes DNase I
T30 1203-1221 DNA_domain_or_region denotes AIR-1 locus defect
T31 1227-1244 DNA_domain_or_region denotes class II promoter
T32 1375-1402 cell_line denotes MHC class II-negative cells