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PubMed:7915282 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Specific binding of the transglutaminase, platelet factor XIII, to HSP27.
T2 74-312 Sentence denotes HSP27, the unique mammalian low molecular weight heat shock protein, is prominently phosphorylated upon activation of a wide variety of cells and has a role in thermotolerance, growth events, and regulation of actin cytoskeletal dynamics.
T3 313-449 Sentence denotes In thrombin-stimulated platelets, HSP27 is rapidly and prominently phosphorylated in a manner highly correlated with platelet secretion.
T4 450-550 Sentence denotes However, the function of HSP27 and the identity of proteins that interact with HSP27 remain unknown.
T5 551-769 Sentence denotes To identify specific HSP27-protein interactions, a recombinant fusion protein affinity reagent was constructed and used to identify proteins associating with HSP27 from human platelet lysates and erythroleukemia cells.
T6 770-989 Sentence denotes An 84-kDa protein was found to associate specifically with HSP27 and was isolated from platelet lysates, resolved on preparative gels, transferred to nitrocellulose, subjected to enzymatic digestion, and microsequenced.
T7 990-1118 Sentence denotes A 20-amino acid sequence derived from p84 proved identical to amino acids 484-503 of the transglutaminase, platelet Factor XIII.
T8 1119-1240 Sentence denotes Immunoblotting studies were used to confirm the binding of FXIII from fresh platelet lysates to the HSP27 fusion protein.
T9 1241-1416 Sentence denotes FXIII also was shown to coprecipitate with HSP27 in immunoprecipitation studies and to colocalize with HSP27 in immunofluorescence studies of intact glass-activated platelets.
T10 1417-1601 Sentence denotes The data thus demonstrate specific binding of platelet FXIII to HSP27 and suggest that HSP27 may participate in the cellular localization and/or enzymatic regulation of platelet FXIII.
T1 0-73 Sentence denotes Specific binding of the transglutaminase, platelet factor XIII, to HSP27.
T2 74-312 Sentence denotes HSP27, the unique mammalian low molecular weight heat shock protein, is prominently phosphorylated upon activation of a wide variety of cells and has a role in thermotolerance, growth events, and regulation of actin cytoskeletal dynamics.
T3 313-449 Sentence denotes In thrombin-stimulated platelets, HSP27 is rapidly and prominently phosphorylated in a manner highly correlated with platelet secretion.
T4 450-550 Sentence denotes However, the function of HSP27 and the identity of proteins that interact with HSP27 remain unknown.
T5 551-769 Sentence denotes To identify specific HSP27-protein interactions, a recombinant fusion protein affinity reagent was constructed and used to identify proteins associating with HSP27 from human platelet lysates and erythroleukemia cells.
T6 770-989 Sentence denotes An 84-kDa protein was found to associate specifically with HSP27 and was isolated from platelet lysates, resolved on preparative gels, transferred to nitrocellulose, subjected to enzymatic digestion, and microsequenced.
T7 990-1118 Sentence denotes A 20-amino acid sequence derived from p84 proved identical to amino acids 484-503 of the transglutaminase, platelet Factor XIII.
T8 1119-1240 Sentence denotes Immunoblotting studies were used to confirm the binding of FXIII from fresh platelet lysates to the HSP27 fusion protein.
T9 1241-1416 Sentence denotes FXIII also was shown to coprecipitate with HSP27 in immunoprecipitation studies and to colocalize with HSP27 in immunofluorescence studies of intact glass-activated platelets.
T10 1417-1601 Sentence denotes The data thus demonstrate specific binding of platelet FXIII to HSP27 and suggest that HSP27 may participate in the cellular localization and/or enzymatic regulation of platelet FXIII.

AIMed

Id Subject Object Predicate Lexical cue
T1 42-62 protein denotes platelet factor XIII
T2 67-72 protein denotes HSP27
T3 74-79 protein denotes HSP27
T4 347-352 protein denotes HSP27
T5 475-480 protein denotes HSP27
T6 529-534 protein denotes HSP27
T7 572-577 protein denotes HSP27
T8 709-714 protein denotes HSP27
T9 829-834 protein denotes HSP27
T10 1178-1183 protein denotes FXIII
T11 1219-1224 protein denotes HSP27
T12 1241-1246 protein denotes FXIII
T13 1284-1289 protein denotes HSP27
T14 1344-1349 protein denotes HSP27
T15 1472-1477 protein denotes FXIII
T16 1481-1486 protein denotes HSP27
T17 1504-1509 protein denotes HSP27
T18 1595-1600 protein denotes FXIII

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 747-762 Disease denotes erythroleukemia http://purl.obolibrary.org/obo/MONDO_0017858

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 720-725 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 42-50 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T2 336-345 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233
T3 430-438 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T4 726-734 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T5 857-865 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T6 1097-1105 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T7 1195-1203 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T8 1406-1415 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233
T9 1463-1471 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T10 1586-1594 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 128-133 Phenotype denotes shock HP:0031273

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 42-50 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T2 336-345 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233
T3 430-438 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T4 726-734 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T5 857-865 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T6 1097-1105 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T7 1195-1203 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T8 1406-1415 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233
T9 1463-1471 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T10 1586-1594 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233