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sentences

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.
T2 88-214 Sentence denotes Acetyl-CoA carboxylase is regulated allosterically by citrate and covalently by a phosphorylation/dephosphorylation mechanism.
T3 215-328 Sentence denotes We have isolated and purified from rat livers a novel kinase that phosphorylates and inactivates the carboxylase.
T4 329-409 Sentence denotes This kinase is bound to the carboxylase and can be eluted in salt-rich solution.
T5 410-522 Sentence denotes The native kinase exists as high molecular weight aggregates of a subunit that has a molecular weight of 40,000.
T6 523-726 Sentence denotes The phosphorylation sites of the carboxylase were determined after tryptic and cyanogen bromide digestions of 32P-labeled carboxylase and separation of the peptides by various chromatographic procedures.
T7 727-847 Sentence denotes Amino acid analyses of the phosphopeptides showed that the Ser77 and Ser1200 residues were the sites of phosphorylation.
T8 848-1005 Sentence denotes Treating the phosphorylated carboxylase with the Mn(2+)-dependent acetyl-CoA carboxylase phosphatase 2 removed the phosphate and reactivated the carboxylase.
T9 1006-1158 Sentence denotes These results suggest that both this kinase and the acetyl-CoA carboxylase phosphatase 2 act at the same site(s) in the acetyl-CoA carboxylase molecule.
T10 1159-1424 Sentence denotes Citrate dramatically inhibits the kinase-mediated phosphorylation of the carboxylase, suggesting that the allosteric modification and activation by citrate render the phosphorylation sites inaccessible to the kinase and therefore maintain high carboxylase activity.
T11 1425-1580 Sentence denotes This observation indicates that there is a close interplay between the citrate effect on and phosphorylation of the carboxylase in regulating its activity.
T1 0-87 Sentence denotes Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.
T2 88-214 Sentence denotes Acetyl-CoA carboxylase is regulated allosterically by citrate and covalently by a phosphorylation/dephosphorylation mechanism.
T3 215-328 Sentence denotes We have isolated and purified from rat livers a novel kinase that phosphorylates and inactivates the carboxylase.
T4 329-409 Sentence denotes This kinase is bound to the carboxylase and can be eluted in salt-rich solution.
T5 410-522 Sentence denotes The native kinase exists as high molecular weight aggregates of a subunit that has a molecular weight of 40,000.
T6 523-726 Sentence denotes The phosphorylation sites of the carboxylase were determined after tryptic and cyanogen bromide digestions of 32P-labeled carboxylase and separation of the peptides by various chromatographic procedures.
T7 727-847 Sentence denotes Amino acid analyses of the phosphopeptides showed that the Ser77 and Ser1200 residues were the sites of phosphorylation.
T8 848-1005 Sentence denotes Treating the phosphorylated carboxylase with the Mn(2+)-dependent acetyl-CoA carboxylase phosphatase 2 removed the phosphate and reactivated the carboxylase.
T9 1006-1158 Sentence denotes These results suggest that both this kinase and the acetyl-CoA carboxylase phosphatase 2 act at the same site(s) in the acetyl-CoA carboxylase molecule.
T10 1159-1424 Sentence denotes Citrate dramatically inhibits the kinase-mediated phosphorylation of the carboxylase, suggesting that the allosteric modification and activation by citrate render the phosphorylation sites inaccessible to the kinase and therefore maintain high carboxylase activity.
T11 1425-1580 Sentence denotes This observation indicates that there is a close interplay between the citrate effect on and phosphorylation of the carboxylase in regulating its activity.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 81-86 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 254-260 http://purl.obolibrary.org/obo/MAT_0000097 denotes livers

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 81-86 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 254-260 Body_part denotes livers http://purl.obolibrary.org/obo/MAT_0000097

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 77-80 OrganismTaxon denotes rat 10114|10116
T3 250-253 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 81-86 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107