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PubMed:7903907 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 89-98 gene:2064 denotes HER-2/neu
T1 125-138 disease:C0678222 denotes breast cancer
T2 89-98 gene:2064 denotes HER-2/neu
T3 125-138 disease:C0006142 denotes breast cancer
T11 202-215 disease:C0006142 denotes breast cancer
T10 180-189 gene:2064 denotes HER-2/neu
T9 202-215 disease:C0678222 denotes breast cancer
T8 180-189 gene:2064 denotes HER-2/neu
T7 202-215 disease:C0006142 denotes breast cancer
T6 242-259 gene:2099 denotes estrogen receptor
T5 202-215 disease:C0678222 denotes breast cancer
T4 242-259 gene:2099 denotes estrogen receptor
R1 T0 T1 associated_with HER-2/neu,breast cancer
R2 T2 T3 associated_with HER-2/neu,breast cancer
R3 T4 T5 associated_with estrogen receptor,breast cancer
R4 T6 T7 associated_with estrogen receptor,breast cancer
R5 T8 T9 associated_with HER-2/neu,breast cancer
R6 T10 T11 associated_with HER-2/neu,breast cancer

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 89-107 DNA denotes HER-2/neu oncogene
T2 180-198 DNA denotes HER-2/neu oncogene
T3 242-259 protein denotes estrogen receptor
T4 386-395 protein denotes HER-2/neu
T5 549-558 protein denotes HER-2/neu
T6 614-628 cell_line denotes K562 cell line
T7 659-683 cell_type denotes natural killer (NK) cell
T8 735-742 cell_type denotes NK cell
T9 805-818 cell_type denotes benign tumors
T10 947-964 protein denotes HER-2/neu protein
T11 997-1004 cell_type denotes NK cell
T12 1087-1096 protein denotes HER-2/neu
T13 1130-1137 cell_type denotes NK cell
T14 1181-1190 protein denotes HER-2/neu
T15 1304-1313 protein denotes HER-2/neu
T16 1355-1364 protein denotes HER-2/neu
T17 1407-1424 protein denotes estrogen receptor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-139 Sentence denotes Increased natural killer cell activity correlates with low or negative expression of the HER-2/neu oncogene in patients with breast cancer.
S2 140-151 Sentence denotes BACKGROUND:
S3 152-321 Sentence denotes Increased expression of the HER-2/neu oncogene in breast cancer correlates with decreased estrogen receptor concentration and seems to be an important prognostic factor.
S4 322-492 Sentence denotes The authors investigated whether there is a correlation between HER-2/neu expression and immunologic parameters representing tumor defense in patients with breast cancer.
S5 493-500 Sentence denotes METHOD:
S6 501-693 Sentence denotes A Western blot analysis was used to investigate HER-2/neu expression, whereas a chromium-release assay using the K562 cell line as target was used to measure natural killer (NK) cell activity.
S7 694-702 Sentence denotes RESULTS:
S8 703-871 Sentence denotes In patients with breast cancer, NK cell activity was significantly higher compared with patients with benign tumors (P = 0.006) or healthy control subjects (P = 0.002).
S9 872-965 Sentence denotes Moreover, 23.3% of patients with breast cancer showed an overexpression of HER-2/neu protein.
S10 966-1129 Sentence denotes Within this group of patients, NK cell activity was significantly lower (45.6 +/- 16.1%) compared with the group with no HER-2/neu overexpression (57.3 +/- 11.0%).
S11 1130-1206 Sentence denotes NK cell activity did not increase in patients with HER-2/neu overexpression.
S12 1207-1444 Sentence denotes Thus, there was a statistically significant correlation of cytolytic effector cell function with HER-2/neu expression of the tumor (P = 0.003), and HER-2/neu overexpression correlated with a negative estrogen receptor status (P = 0.005).
S13 1445-1456 Sentence denotes CONCLUSION:
S14 1457-1642 Sentence denotes These data add further evidence to previous observations from the authors' laboratory that certain tumor characteristics may be associated with reactions of the host with breast cancer.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 10-38 NP denotes natural killer cell activity
C4 111-138 NP denotes patients with breast cancer
C3 85-138 NP denotes the HER-2/neu oncogene in patients with breast cancer
C2 55-138 NP denotes low or negative expression of the HER-2/neu oncogene in patients with breast cancer
C5 176-215 NP denotes the HER-2/neu oncogene in breast cancer
C6 386-406 NP denotes HER-2/neu expression
C7 464-491 NP denotes patients with breast cancer
C8 549-569 NP denotes HER-2/neu expression
C9 659-692 NP denotes natural killer (NK) cell activity
C10 706-733 NP denotes patients with breast cancer
C11 735-751 NP denotes NK cell activity
C12 882-918 NP denotes 23.3% of patients with breast cancer
C13 926-964 NP denotes an overexpression of HER-2/neu protein
C14 973-995 NP denotes this group of patients
C15 997-1013 NP denotes NK cell activity
C16 1130-1146 NP denotes NK cell activity
C18 1181-1205 NP denotes HER-2/neu overexpression
C17 1167-1205 NP denotes patients with HER-2/neu overexpression
C19 1304-1324 NP denotes HER-2/neu expression
C20 1355-1379 NP denotes HER-2/neu overexpression
C21 1492-1542 NP denotes previous observations from the authors' laboratory
C22 1543-1547 NP denotes that
C23 1614-1641 NP denotes the host with breast cancer
R1 C5 C3 coref-ident the HER-2/neu oncogene in breast cancer,the HER-2/neu oncogene in patients with breast cancer
R2 C6 C2 coref-other HER-2/neu expression,low or negative expression of the HER-2/neu oncogene in patients with breast cancer
R3 C7 C4 coref-ident patients with breast cancer,patients with breast cancer
R4 C8 C6 coref-ident HER-2/neu expression,HER-2/neu expression
R5 C9 C1 coref-ident natural killer (NK) cell activity,natural killer cell activity
R6 C10 C7 coref-ident patients with breast cancer,patients with breast cancer
R7 C11 C9 coref-ident NK cell activity,natural killer (NK) cell activity
R8 C12 C10 coref-part-whole 23.3% of patients with breast cancer,patients with breast cancer
R9 C14 C12 coref-ident this group of patients,23.3% of patients with breast cancer
R10 C15 C11 coref-ident NK cell activity,NK cell activity
R11 C16 C15 coref-ident NK cell activity,NK cell activity
R12 C18 C13 coref-ident HER-2/neu overexpression,an overexpression of HER-2/neu protein
R13 C17 C12 coref-ident patients with HER-2/neu overexpression,23.3% of patients with breast cancer
R14 C19 C6 coref-ident HER-2/neu expression,HER-2/neu expression
R15 C22 C21 coref-relat that,previous observations from the authors' laboratory
R16 C23 C10 coref-ident the host with breast cancer,patients with breast cancer

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 10-38 other_name denotes natural killer cell activity
T2 89-107 DNA_domain_or_region denotes HER-2/neu oncogene
T3 111-119 multi_cell denotes patients
T4 125-138 other_name denotes breast cancer
T5 180-198 DNA_domain_or_region denotes HER-2/neu oncogene
T6 202-215 other_name denotes breast cancer
T7 242-250 lipid denotes estrogen
T8 386-395 protein_molecule denotes HER-2/neu
T9 411-433 other_name denotes immunologic parameters
T10 464-472 multi_cell denotes patients
T11 478-491 other_name denotes breast cancer
T12 503-524 other_name denotes Western blot analysis
T13 549-558 protein_molecule denotes HER-2/neu
T14 581-603 other_name denotes chromium-release assay
T15 614-628 cell_line denotes K562 cell line
T16 659-683 cell_type denotes natural killer (NK) cell
T17 706-714 multi_cell denotes patients
T18 720-733 other_name denotes breast cancer
T19 735-742 cell_type denotes NK cell
T20 791-799 multi_cell denotes patients
T21 805-818 cell_type denotes benign tumors
T22 834-858 multi_cell denotes healthy control subjects
T23 891-899 multi_cell denotes patients
T24 905-918 other_name denotes breast cancer
T25 947-956 protein_molecule denotes HER-2/neu
T26 987-995 multi_cell denotes patients
T27 997-1004 cell_type denotes NK cell
T28 1087-1096 protein_molecule denotes HER-2/neu
T29 1130-1137 cell_type denotes NK cell
T30 1167-1175 multi_cell denotes patients
T31 1181-1190 protein_molecule denotes HER-2/neu
T32 1304-1313 protein_molecule denotes HER-2/neu
T33 1355-1364 protein_molecule denotes HER-2/neu
T34 1407-1415 lipid denotes estrogen
T35 1556-1577 other_name denotes tumor characteristics
T36 1628-1641 other_name denotes breast cancer