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PubMed:7895225 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 200-209 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T3 408-417 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T5 498-507 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 200-209 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T2 200-209 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T3 408-417 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T4 408-417 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T5 498-507 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T6 498-507 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 915-919 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-81 Sentence denotes Structural and functional-group tuning in the design of neuraminidase inhibitors.
TextSentencer_T2 82-319 Sentence denotes Analogues of the disaccharide alpha-NeuAc-(2-->6)-beta-D-Gal-OR have been made by modifications at C-1 and C-6 of the galactose and at C-4 of the NeuAc unit, for structure-activity relationship studies with influenza virus neuraminidase.
TextSentencer_T3 320-547 Sentence denotes These studies indicate that for the influenza neuraminidase, a larger aglycon at C-1 of galactose is less preferred, whereas the restriction of the rotamer orientation at C-6 of galactose in the "tg" mode favors enzyme binding.
TextSentencer_T4 548-672 Sentence denotes Substitution at C-4 of the NeuAc unit has the most profound effect in the influenza neuraminidase hydrolysis and inhibition.
TextSentencer_T5 673-799 Sentence denotes For example, azido and acetamido groups at C-4 of the NeuAc units render the sialosides resistant to neuraminidase hydrolysis.
TextSentencer_T6 800-901 Sentence denotes However, these derivatives are not inhibitors of the neuraminidase, indicating their lack of binding.
TextSentencer_T7 902-1085 Sentence denotes On the other hand, a 4-amino substitution of the NeuAc unit not only renders the corresponding sialosides neuraminidase-resistant, but also makes them potent neuraminidase inhibitors.
TextSentencer_T8 1086-1249 Sentence denotes This potent inhibition indicates that the 4-amino groups in these sialosides may engage in favorable interaction with amino acids at the neuraminidase active-site.
TextSentencer_T9 1250-1366 Sentence denotes The conclusion is also supported by docking studies of the carbohydrate structures at the neuraminidase active-site.
T1 0-81 Sentence denotes Structural and functional-group tuning in the design of neuraminidase inhibitors.
T2 82-319 Sentence denotes Analogues of the disaccharide alpha-NeuAc-(2-->6)-beta-D-Gal-OR have been made by modifications at C-1 and C-6 of the galactose and at C-4 of the NeuAc unit, for structure-activity relationship studies with influenza virus neuraminidase.
T3 320-547 Sentence denotes These studies indicate that for the influenza neuraminidase, a larger aglycon at C-1 of galactose is less preferred, whereas the restriction of the rotamer orientation at C-6 of galactose in the "tg" mode favors enzyme binding.
T4 548-672 Sentence denotes Substitution at C-4 of the NeuAc unit has the most profound effect in the influenza neuraminidase hydrolysis and inhibition.
T5 673-799 Sentence denotes For example, azido and acetamido groups at C-4 of the NeuAc units render the sialosides resistant to neuraminidase hydrolysis.
T6 800-901 Sentence denotes However, these derivatives are not inhibitors of the neuraminidase, indicating their lack of binding.
T7 902-1085 Sentence denotes On the other hand, a 4-amino substitution of the NeuAc unit not only renders the corresponding sialosides neuraminidase-resistant, but also makes them potent neuraminidase inhibitors.
T8 1086-1249 Sentence denotes This potent inhibition indicates that the 4-amino groups in these sialosides may engage in favorable interaction with amino acids at the neuraminidase active-site.
T9 1250-1366 Sentence denotes The conclusion is also supported by docking studies of the carbohydrate structures at the neuraminidase active-site.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 118-123 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 228-233 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 575-580 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 727-732 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5 951-956 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 289-298 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 356-365 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 622-631 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 118-123 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 228-233 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 575-580 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 727-732 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5 951-956 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 915-919 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 289-298 Disease denotes influenza MONDO:0005812
T2 356-365 Disease denotes influenza MONDO:0005812
T3 622-631 Disease denotes influenza MONDO:0005812

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Structural and functional-group tuning in the design of neuraminidase inhibitors.
T2 82-319 Sentence denotes Analogues of the disaccharide alpha-NeuAc-(2-->6)-beta-D-Gal-OR have been made by modifications at C-1 and C-6 of the galactose and at C-4 of the NeuAc unit, for structure-activity relationship studies with influenza virus neuraminidase.
T3 320-547 Sentence denotes These studies indicate that for the influenza neuraminidase, a larger aglycon at C-1 of galactose is less preferred, whereas the restriction of the rotamer orientation at C-6 of galactose in the "tg" mode favors enzyme binding.
T4 548-672 Sentence denotes Substitution at C-4 of the NeuAc unit has the most profound effect in the influenza neuraminidase hydrolysis and inhibition.
T5 673-799 Sentence denotes For example, azido and acetamido groups at C-4 of the NeuAc units render the sialosides resistant to neuraminidase hydrolysis.
T6 800-901 Sentence denotes However, these derivatives are not inhibitors of the neuraminidase, indicating their lack of binding.
T7 902-1085 Sentence denotes On the other hand, a 4-amino substitution of the NeuAc unit not only renders the corresponding sialosides neuraminidase-resistant, but also makes them potent neuraminidase inhibitors.
T8 1086-1249 Sentence denotes This potent inhibition indicates that the 4-amino groups in these sialosides may engage in favorable interaction with amino acids at the neuraminidase active-site.
T9 1250-1366 Sentence denotes The conclusion is also supported by docking studies of the carbohydrate structures at the neuraminidase active-site.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 915-919 Body_part denotes hand FMA:9712

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 915-919 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 915-919 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 915-919 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091