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PubMed:7890768 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 329-339 Cell denotes hepatocyte http://purl.obolibrary.org/obo/CL:0000182
T2 436-442 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T4 498-504 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T6 880-886 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138

sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism.
T2 97-221 Sentence denotes The beta:beta activin homodimer and alpha:beta inhibin heterodimer are mutual antagonists which share a common beta subunit.
T3 222-354 Sentence denotes Recently, it has been shown that, similar to transforming growth factor-beta 1, activin is an inhibitor of hepatocyte DNA synthesis.
T4 355-489 Sentence denotes The activin receptor appears to be an obligatory complex of genetically distinct type I and II transmembrane serine/threonine kinases.
T5 490-603 Sentence denotes Activin type I receptors, SKR1 and SKR2, were first cloned from well differentiated human hepatoma cells (HepG2).
T6 604-752 Sentence denotes This prompted us to investigate the binding of activin and inhibin to receptors from HepG2 cells and the effect of the two ligands on DNA synthesis.
T7 753-1010 Sentence denotes Here we show that beta:beta activin binds to the activin type II receptor kinase (ActRII) which induces activin binding to the type I receptor kinase SKR2 to form ActRII.beta:beta.SKR2 complexes in which an activin beta chain occupies each receptor subunit.
T8 1011-1156 Sentence denotes Inhibin also binds to ActRII through its beta subunit, competes with the binding of activin to ActRII, but fails to form the ActRII.SKR2 complex.
T9 1157-1231 Sentence denotes No specific binding site for inhibin could be demonstrated in HepG2 cells.
T10 1232-1337 Sentence denotes Inhibin, which had no activity of its own, antagonized the inhibitory effect of activin on DNA synthesis.
T11 1338-1495 Sentence denotes The results suggest that inhibin may be a natural antagonist of assembly of the heterodimeric activin receptor complex through a dominant-negative mechanism.
T1 0-96 Sentence denotes Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism.
T2 97-221 Sentence denotes The beta:beta activin homodimer and alpha:beta inhibin heterodimer are mutual antagonists which share a common beta subunit.
T3 222-354 Sentence denotes Recently, it has been shown that, similar to transforming growth factor-beta 1, activin is an inhibitor of hepatocyte DNA synthesis.
T4 355-489 Sentence denotes The activin receptor appears to be an obligatory complex of genetically distinct type I and II transmembrane serine/threonine kinases.
T5 490-603 Sentence denotes Activin type I receptors, SKR1 and SKR2, were first cloned from well differentiated human hepatoma cells (HepG2).
T6 604-752 Sentence denotes This prompted us to investigate the binding of activin and inhibin to receptors from HepG2 cells and the effect of the two ligands on DNA synthesis.
T7 753-1010 Sentence denotes Here we show that beta:beta activin binds to the activin type II receptor kinase (ActRII) which induces activin binding to the type I receptor kinase SKR2 to form ActRII.beta:beta.SKR2 complexes in which an activin beta chain occupies each receptor subunit.
T8 1011-1156 Sentence denotes Inhibin also binds to ActRII through its beta subunit, competes with the binding of activin to ActRII, but fails to form the ActRII.SKR2 complex.
T9 1157-1231 Sentence denotes No specific binding site for inhibin could be demonstrated in HepG2 cells.
T10 1232-1337 Sentence denotes Inhibin, which had no activity of its own, antagonized the inhibitory effect of activin on DNA synthesis.
T11 1338-1495 Sentence denotes The results suggest that inhibin may be a natural antagonist of assembly of the heterodimeric activin receptor complex through a dominant-negative mechanism.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 34-39 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

AIMed

Id Subject Object Predicate Lexical cue
T1 0-7 protein denotes Inhibin
T2 106-118 protein denotes beta activin
T3 139-151 protein denotes beta inhibin
T4 267-300 protein denotes transforming growth factor-beta 1
T5 516-520 protein denotes SKR1
T6 525-529 protein denotes SKR2
T7 776-788 protein denotes beta activin
T8 802-833 protein denotes activin type II receptor kinase
T9 835-841 protein denotes ActRII
T10 903-907 protein denotes SKR2
T11 916-922 protein denotes ActRII
T12 933-937 protein denotes SKR2
T13 960-972 protein denotes activin beta
T14 1011-1018 protein denotes Inhibin
T15 1033-1039 protein denotes ActRII
T16 1106-1112 protein denotes ActRII
T17 1136-1142 protein denotes ActRII
T18 1143-1147 protein denotes SKR2
T19 1232-1239 protein denotes Inhibin
T20 1432-1448 protein denotes activin receptor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 580-588 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 574-579 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 34-39 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 329-339 Body_part denotes hepatocyte http://purl.obolibrary.org/obo/CL_0000182
T3 450-463 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 34-39 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097