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PubMed:7888666 JSONTXT

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jnlpba-st-training

Id	Subject	Object	Predicate	Lexical cue
T1	0-13	protein	denotes	Interleukin-5
T2	27-44	cell_type	denotes	human eosinophils
T3	54-74	protein	denotes	JAK2 tyrosine kinase
T4	79-90	protein	denotes	Stat1 alpha
T5	123-132	protein	denotes	cytokines
T6	144-155	protein	denotes	interferons
T7	157-169	protein	denotes	interleukins
T8	175-189	protein	denotes	growth factors
T9	214-225	protein	denotes	JAK kinases
T10	230-296	protein	denotes	Stat (Signal transducers and activators of transcription) proteins
T11	368-381	protein	denotes	interleukin-5
T12	383-387	protein	denotes	IL-5
T13	426-443	cell_type	denotes	Human eosinophils
T14	474-486	cell_type	denotes	target cells
T15	491-495	protein	denotes	IL-5
T16	524-528	protein	denotes	IL-5
T17	544-562	cell_type	denotes	primary human cell
T18	564-568	protein	denotes	IL-5
T19	625-629	protein	denotes	JAK2
T20	641-645	protein	denotes	IL-5
T21	667-688	protein	denotes	DNA-binding complexes
T22	725-742	cell_type	denotes	human eosinophils
T23	751-789	DNA	denotes	IL-6/interferon-gamma response element
T24	797-812	DNA	denotes	ICAM-1 promoter
T25	814-825	DNA	denotes	ICAM-1 pIRE
T26	916-935	protein	denotes	DNA-binding complex
T27	946-957	protein	denotes	Stat1 alpha
T28	989-1010	protein	denotes	DNA-binding complexes
T29	1031-1055	protein	denotes	phosphotyrosine antibody
T30	1057-1061	protein	denotes	4G10
T31	1140-1144	protein	denotes	IL-3
T32	1149-1197	protein	denotes	granulocyte-macrophage colony-stimulating factor
T33	1218-1222	protein	denotes	IL-5
T34	1228-1249	protein	denotes	DNA-binding complexes
T35	1253-1270	cell_type	denotes	human eosinophils
T36	1282-1293	protein	denotes	Stat1 alpha
T37	1359-1363	protein	denotes	IL-5
T38	1377-1394	cell_type	denotes	human eosinophils
T39	1418-1435	protein	denotes	JAK kinase family
T40	1462-1473	protein	denotes	Stat family

genia-medco-coref

Id	Subject	Object	Predicate	Lexical cue
C1	0-23	NP	denotes	Interleukin-5 signaling
C2	27-44	NP	denotes	human eosinophils
C3	214-296	NP	denotes	JAK kinases and Stat (Signal transducers and activators of transcription) proteins
C4	334-358	NP	denotes	the molecular mechanisms
C5	362-367	NP	denotes	which
C6	368-388	NP	denotes	interleukin-5 (IL-5)
C7	396-399	NP	denotes	its
C8	426-443	NP	denotes	Human eosinophils
C9	491-495	NP	denotes	IL-5
C10	524-538	NP	denotes	IL-5 signaling
C11	564-568	NP	denotes	IL-5
C12	641-645	NP	denotes	IL-5
C13	654-688	NP	denotes	at least two DNA-binding complexes
C14	946-957	NP	denotes	Stat1 alpha
C15	984-1010	NP	denotes	Both DNA-binding complexes
C16	1218-1222	NP	denotes	IL-5
C18	1253-1270	NP	denotes	human eosinophils
C17	1224-1270	NP	denotes	two DNA-binding complexes in human eosinophils
C19	1282-1293	NP	denotes	Stat1 alpha
C20	1359-1373	NP	denotes	IL-5 signaling
C21	1377-1394	NP	denotes	human eosinophils
C22	1403-1473	NP	denotes	members of the JAK kinase family as well as members of the Stat family
R1	C5	C4	coref-relat	which,the molecular mechanisms
R2	C7	C6	coref-pron	its,interleukin-5 (IL-5)
R3	C8	C2	coref-ident	Human eosinophils,human eosinophils
R4	C9	C6	coref-ident	IL-5,interleukin-5 (IL-5)
R5	C10	C1	coref-ident	IL-5 signaling,Interleukin-5 signaling
R6	C11	C9	coref-ident	IL-5,IL-5
R7	C12	C11	coref-ident	IL-5,IL-5
R8	C15	C13	coref-ident	Both DNA-binding complexes,at least two DNA-binding complexes
R9	C16	C12	coref-ident	IL-5,IL-5
R10	C18	C8	coref-ident	human eosinophils,Human eosinophils
R11	C17	C15	coref-ident	two DNA-binding complexes in human eosinophils,Both DNA-binding complexes
R12	C19	C14	coref-ident	Stat1 alpha,Stat1 alpha
R13	C20	C10	coref-ident	IL-5 signaling,IL-5 signaling
R14	C21	C18	coref-ident	human eosinophils,human eosinophils
R15	C22	C3	coref-ident	members of the JAK kinase family as well as members of the Stat family,JAK kinases and Stat (Signal transducers and activators of transcription) proteins

pubmed-sentences-benchmark

Id	Subject	Object	Predicate	Lexical cue
S1	0-91	Sentence	denotes	Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha.
S2	92-297	Sentence	denotes	Signaling by a wide variety of cytokines, including interferons, interleukins, and growth factors, involves activation of JAK kinases and Stat (Signal transducers and activators of transcription) proteins.
S3	298-425	Sentence	denotes	At present, not much is known about the molecular mechanisms by which interleukin-5 (IL-5) exerts its diverse biologic effects.
S4	426-563	Sentence	denotes	Human eosinophils are one of the most important target cells for IL-5 and were used here to study IL-5 signaling in a primary human cell.
S5	564-630	Sentence	denotes	IL-5 induced rapid and transient tyrosine phosphorylation of JAK2.
S6	631-861	Sentence	denotes	Moreover, IL-5 induced at least two DNA-binding complexes, using nuclear extracts from normal human eosinophils and the IL-6/interferon-gamma response element of the ICAM-1 promoter (ICAM-1 pIRE) in an electromobility shift assay.
S7	862-983	Sentence	denotes	From supershift experiments it was concluded that one DNA-binding complex contained Stat1 alpha, probably as a homodimer.
S8	984-1139	Sentence	denotes	Both DNA-binding complexes were inhibited by a phosphotyrosine antibody (4G10), suggesting that tyrosine phosphorylation is required for complex formation.
S9	1140-1294	Sentence	denotes	IL-3 and granulocyte-macrophage colony-stimulating factor induced, similar to IL-5, two DNA-binding complexes in human eosinophils, including Stat1 alpha.
S10	1295-1474	Sentence	denotes	These data show for the first time that molecular mechanisms of IL-5 signaling in human eosinophils involve members of the JAK kinase family as well as members of the Stat family.

GENIAcorpus

Id	Subject	Object	Predicate	Lexical cue
T1	0-13	protein_molecule	denotes	Interleukin-5
T2	27-44	cell_type	denotes	human eosinophils
T3	54-58	protein_molecule	denotes	JAK2
T4	79-90	protein_molecule	denotes	Stat1 alpha
T5	123-132	protein_family_or_group	denotes	cytokines
T6	144-155	protein_family_or_group	denotes	interferons
T7	157-169	protein_family_or_group	denotes	interleukins
T8	175-189	protein_family_or_group	denotes	growth factors
T9	214-225	protein_family_or_group	denotes	JAK kinases
T10	230-234	protein_family_or_group	denotes	Stat
T11	236-286	protein_family_or_group	denotes	Signal transducers and activators of transcription
T12	368-381	protein_molecule	denotes	interleukin-5
T13	383-387	protein_molecule	denotes	IL-5
T14	400-424	other_name	denotes	diverse biologic effects
T15	426-443	cell_type	denotes	Human eosinophils
T16	474-486	cell_type	denotes	target cells
T17	491-495	protein_molecule	denotes	IL-5
T18	524-528	protein_molecule	denotes	IL-5
T19	544-562	cell_type	denotes	primary human cell
T20	564-568	protein_molecule	denotes	IL-5
T21	597-605	amino_acid_monomer	denotes	tyrosine
T22	625-629	protein_molecule	denotes	JAK2
T23	641-645	protein_molecule	denotes	IL-5
T24	667-688	protein_complex	denotes	DNA-binding complexes
T25	696-712	cell_component	denotes	nuclear extracts
T26	725-742	cell_type	denotes	human eosinophils
T27	751-789	DNA_domain_or_region	denotes	IL-6/interferon-gamma response element
T28	797-812	DNA_domain_or_region	denotes	ICAM-1 promoter
T29	814-825	DNA_domain_or_region	denotes	ICAM-1 pIRE
T30	833-860	other_name	denotes	electromobility shift assay
T31	867-889	other_name	denotes	supershift experiments
T32	916-935	protein_complex	denotes	DNA-binding complex
T33	946-957	protein_molecule	denotes	Stat1 alpha
T34	989-1010	protein_complex	denotes	DNA-binding complexes
T35	1031-1055	protein_family_or_group	denotes	phosphotyrosine antibody
T36	1057-1061	protein_molecule	denotes	4G10
T37	1080-1088	amino_acid_monomer	denotes	tyrosine
T38	1121-1138	other_name	denotes	complex formation
T39	1140-1144	protein_family_or_group	denotes	IL-3
T40	1149-1197	protein_molecule	denotes	granulocyte-macrophage colony-stimulating factor
T41	1218-1222	protein_molecule	denotes	IL-5
T42	1228-1249	protein_complex	denotes	DNA-binding complexes
T43	1253-1270	cell_type	denotes	human eosinophils
T44	1282-1293	protein_molecule	denotes	Stat1 alpha
T45	1359-1363	protein_molecule	denotes	IL-5
T46	1377-1394	cell_type	denotes	human eosinophils
T47	1418-1435	protein_family_or_group	denotes	JAK kinase family
T48	1462-1473	protein_family_or_group	denotes	Stat family