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PubMed:7869038 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-46 protein denotes Calcium/calmodulin-dependent protein kinase II
T2 121-134 DNA denotes cytokine gene
T3 152-165 cell_type denotes human T cells
T4 185-200 protein denotes T cell receptor
T5 223-238 protein denotes phospholipase C
T6 336-352 protein denotes protein kinase C
T7 354-357 protein denotes PKC
T8 388-421 protein denotes Ca2+/calmodulin-dependent kinases
T9 452-495 protein denotes Ca2+/calmodulin-dependent protein kinase II
T10 497-505 protein denotes CaM-K II
T11 519-530 protein denotes calcineurin
T12 534-561 protein denotes type 2B protein phosphatase
T13 594-605 protein denotes calcineurin
T14 696-704 protein denotes CaM-K II
T15 752-759 protein denotes kinases
T16 764-776 protein denotes phosphatases
T17 778-791 protein denotes gamma B*CaM-K
T18 796-808 protein denotes delta CaM-AI
T19 858-871 DNA denotes cytokine gene
T20 914-917 protein denotes PKC
T21 947-960 protein denotes gamma B*CaM-K
T22 965-977 protein denotes delta CaM-AI
T23 1086-1100 cell_line denotes Jurkat T cells
T24 1138-1151 DNA denotes IL-2 promoter
T25 1182-1229 DNA denotes chloramphenicol acetyltransferase reporter gene
T26 1249-1262 protein denotes gamma B*CaM-K
T27 1272-1295 DNA denotes IL-2 promoter construct
T28 1432-1440 protein denotes CaM-K II
T29 1444-1457 DNA denotes IL-2 promoter
T30 1577-1589 protein denotes delta CaM-AI
T31 1603-1616 DNA denotes IL-2 promoter
T32 1704-1717 protein denotes gamma B*CaM-K
T33 1749-1762 DNA denotes IL-2 promoter
T34 1766-1778 protein denotes delta CaM-AI
T35 1842-1855 DNA denotes IL-4 promoter
T36 1871-1884 protein denotes gamma B*CaM-K
T37 1922-1926 protein denotes AP-1
T38 1994-1997 protein denotes PKC
T39 2050-2058 protein denotes CaM-K II
T40 2092-2105 DNA denotes cytokine gene
T41 2123-2136 cell_type denotes human T cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-166 Sentence denotes Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.
S2 167-359 Sentence denotes Engagement of the T cell receptor for antigen activates phospholipase C resulting in an increase in intracellular free calcium concentration ([Ca2+]i) and activation of protein kinase C (PKC).
S3 360-562 Sentence denotes Increased [Ca2+]i activates Ca2+/calmodulin-dependent kinases including the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaM-K II), as well as calcineurin, a type 2B protein phosphatase.
S4 563-674 Sentence denotes Recent studies have identified calcineurin as a key enzyme for interleukin (IL)-2 and IL-4 promoter activation.
S5 675-721 Sentence denotes However, the role of CaM-K II remains unknown.
S6 722-946 Sentence denotes We have used mutants of these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively) to explore their relative role in cytokine gene transcription and their interactions with PKC-dependent signaling systems.
S7 947-1230 Sentence denotes gamma B*CaM-K and delta CaM-AI, known to exhibit constitutive Ca(2+)-independent activity, were cotransfected (alone or in combination) in Jurkat T cells with a plasmid containing the intact IL-2 promoter driving the expression of the chloramphenicol acetyltransferase reporter gene.
S8 1231-1406 Sentence denotes Cotransfection of gamma B*CaM-K with the IL-2 promoter construct downregulated its transcription in response to stimulation with ionomycin and phorbol myristate acetate (PMA).
S9 1407-1549 Sentence denotes The inhibitory effect of CaM-K II on IL-2 promoter was associated with decreased transcription of its AP-1 and NF-AT transactivating pathways.
S10 1550-1659 Sentence denotes Under the same conditions, delta CaM-AI superinduced IL-2 promoter activity (approximately twofold increase).
S11 1660-1779 Sentence denotes When both mutants were used in combination, gamma B*CaM-K inhibited the induction of the IL-2 promoter by delta CaM-AI.
S12 1780-1870 Sentence denotes Similar results were obtained when a construct containing the IL-4 promoter also was used.
S13 1871-2022 Sentence denotes gamma B*CaM-K also downregulated the activation of AP-1 in response to transfection with a constitutively active mutant of PKC or stimulation with PMA.
S14 2023-2253 Sentence denotes These results suggest that CaM-K II may exert negative influences on cytokine gene transcription in human T cells, and provide preliminary evidence for negative cross-talk with the calcineurin- and PKC-dependent signaling systems.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 152-165 NP denotes human T cells
C1 121-165 NP denotes cytokine gene transcription in human T cells
C3 336-358 NP denotes protein kinase C (PKC)
C4 388-421 NP denotes Ca2+/calmodulin-dependent kinases
C5 432-506 NP denotes the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaM-K II)
C6 519-530 NP denotes calcineurin
C7 532-561 NP denotes a type 2B protein phosphatase
C8 594-605 NP denotes calcineurin
C9 696-704 NP denotes CaM-K II
C11 746-759 NP denotes these kinases
C10 746-823 NP denotes these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively)
C12 835-840 NP denotes their
C13 890-895 NP denotes their
C14 947-960 NP denotes gamma B*CaM-K
C15 965-977 NP denotes delta CaM-AI
C16 1086-1100 NP denotes Jurkat T cells
C17 1127-1151 NP denotes the intact IL-2 promoter
C18 1249-1262 NP denotes gamma B*CaM-K
C19 1310-1313 NP denotes its
C20 1374-1405 NP denotes phorbol myristate acetate (PMA)
C21 1432-1440 NP denotes CaM-K II
C22 1444-1457 NP denotes IL-2 promoter
C23 1577-1589 NP denotes delta CaM-AI
C24 1704-1717 NP denotes gamma B*CaM-K
C25 1745-1762 NP denotes the IL-2 promoter
C26 1766-1778 NP denotes delta CaM-AI
C27 1871-1884 NP denotes gamma B*CaM-K
C28 1994-1997 NP denotes PKC
C29 2018-2021 NP denotes PMA
C30 2050-2058 NP denotes CaM-K II
C32 2123-2136 NP denotes human T cells
C31 2092-2136 NP denotes cytokine gene transcription in human T cells
R1 C7 C6 coref-appos a type 2B protein phosphatase,calcineurin
R2 C8 C6 coref-ident calcineurin,calcineurin
R3 C9 C5 coref-ident CaM-K II,the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaM-K II)
R4 C11 C4 coref-ident these kinases,Ca2+/calmodulin-dependent kinases
R5 C12 C10 coref-pron their,"these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively)"
R6 C13 C10 coref-pron their,"these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively)"
R7 C16 C2 coref-ident Jurkat T cells,human T cells
R8 C18 C14 coref-ident gamma B*CaM-K,gamma B*CaM-K
R9 C19 C18 coref-pron its,gamma B*CaM-K
R10 C21 C9 coref-ident CaM-K II,CaM-K II
R11 C22 C17 coref-ident IL-2 promoter,the intact IL-2 promoter
R12 C23 C15 coref-ident delta CaM-AI,delta CaM-AI
R13 C24 C18 coref-ident gamma B*CaM-K,gamma B*CaM-K
R14 C25 C22 coref-ident the IL-2 promoter,IL-2 promoter
R15 C26 C23 coref-ident delta CaM-AI,delta CaM-AI
R16 C27 C24 coref-ident gamma B*CaM-K,gamma B*CaM-K
R17 C28 C3 coref-ident PKC,protein kinase C (PKC)
R18 C29 C20 coref-ident PMA,phorbol myristate acetate (PMA)
R19 C30 C21 coref-ident CaM-K II,CaM-K II
R20 C32 C16 coref-ident human T cells,Jurkat T cells
R21 C31 C1 coref-ident cytokine gene transcription in human T cells,cytokine gene transcription in human T cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-46 protein_molecule denotes Calcium/calmodulin-dependent protein kinase II
T2 121-129 protein_family_or_group denotes cytokine
T3 152-165 cell_type denotes human T cells
T4 185-200 protein_family_or_group denotes T cell receptor
T5 205-212 other_name denotes antigen
T6 223-238 protein_molecule denotes phospholipase C
T7 267-285 other_name denotes intracellular free
T8 286-293 atom denotes calcium
T9 309-310 other_name denotes [
T10 310-314 atom denotes Ca2+
T11 336-352 protein_molecule denotes protein kinase C
T12 354-357 protein_molecule denotes PKC
T13 370-371 other_name denotes [
T14 371-375 atom denotes Ca2+
T15 388-392 atom denotes Ca2+
T16 452-456 atom denotes Ca2+
T17 497-505 protein_molecule denotes CaM-K II
T18 519-530 protein_molecule denotes calcineurin
T19 534-561 protein_family_or_group denotes type 2B protein phosphatase
T20 594-605 protein_molecule denotes calcineurin
T21 696-704 protein_molecule denotes CaM-K II
T22 752-759 protein_family_or_group denotes kinases
T23 764-776 protein_family_or_group denotes phosphatases
T24 778-791 protein_molecule denotes gamma B*CaM-K
T25 796-808 protein_molecule denotes delta CaM-AI
T26 858-866 protein_family_or_group denotes cytokine
T27 914-917 protein_molecule denotes PKC
T28 947-960 protein_molecule denotes gamma B*CaM-K
T29 965-977 protein_molecule denotes delta CaM-AI
T30 1009-1036 other_name denotes Ca(2+)-independent activity
T31 1086-1100 cell_line denotes Jurkat T cells
T32 1138-1151 DNA_domain_or_region denotes IL-2 promoter
T33 1182-1229 DNA_molecule denotes chloramphenicol acetyltransferase reporter gene
T34 1249-1262 protein_molecule denotes gamma B*CaM-K
T35 1272-1285 DNA_domain_or_region denotes IL-2 promoter
T36 1360-1369 other_organic_compound denotes ionomycin
T37 1374-1399 other_organic_compound denotes phorbol myristate acetate
T38 1401-1404 other_organic_compound denotes PMA
T39 1432-1440 protein_molecule denotes CaM-K II
T40 1444-1457 DNA_domain_or_region denotes IL-2 promoter
T41 1577-1589 protein_molecule denotes delta CaM-AI
T42 1603-1616 DNA_domain_or_region denotes IL-2 promoter
T43 1704-1717 protein_molecule denotes gamma B*CaM-K
T44 1749-1762 DNA_domain_or_region denotes IL-2 promoter
T45 1766-1778 protein_molecule denotes delta CaM-AI
T46 1842-1846 protein_molecule denotes IL-4
T47 1871-1884 protein_molecule denotes gamma B*CaM-K
T48 1922-1926 protein_molecule denotes AP-1
T49 1994-1997 protein_molecule denotes PKC
T50 2018-2021 other_organic_compound denotes PMA
T51 2050-2058 protein_molecule denotes CaM-K II
T52 2092-2100 protein_family_or_group denotes cytokine
T53 2123-2136 cell_type denotes human T cells
T54 2175-2194 other_name denotes negative cross-talk