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PubMed:7858491 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 70-75 gene:1436 denotes C-FMS
T1 142-167 disease:C0026986 denotes myelodysplastic syndromes
T2 108-113 gene:1958 denotes EGR-1
T3 142-167 disease:C0026986 denotes myelodysplastic syndromes
T4 119-124 gene:1435 denotes M-CSF
T5 142-167 disease:C0026986 denotes myelodysplastic syndromes
R1 T0 T1 associated_with C-FMS,myelodysplastic syndromes
R2 T2 T3 associated_with EGR-1,myelodysplastic syndromes
R3 T4 T5 associated_with M-CSF,myelodysplastic syndromes

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 40-46 protein denotes GM-CSF
T2 48-52 protein denotes IL-3
T3 54-68 protein denotes M-CSF receptor
T4 70-75 protein denotes C-FMS
T5 78-106 DNA denotes early growth response gene-1
T6 108-113 DNA denotes EGR-1
T7 119-130 DNA denotes M-CSF genes
T8 309-315 cell_type denotes blasts
T9 394-427 DNA denotes IL-3, GM-CSF, FMS and EGR-1 genes
T10 457-481 DNA denotes long arm of chromosome 5
T11 505-515 DNA denotes M-CSF gene
T12 558-583 DNA denotes short arm of chromosome 1
T13 585-587 DNA denotes lp
T14 742-759 cell_line denotes neoplastic clones
T15 826-832 DNA denotes allele
T16 870-876 DNA denotes allele
T17 902-916 cell_type denotes leukemic cells
T18 978-994 DNA denotes constitutive DNA
T19 1000-1016 cell_type denotes skin fibroblasts
T20 1022-1034 DNA denotes leukemic DNA
T21 1091-1101 DNA denotes M-CSF gene
T22 1135-1138 DNA denotes FMS
T23 1147-1158 DNA denotes EGR-1 genes
T24 1310-1329 DNA denotes M-CSF and FMS genes
T25 1461-1487 protein denotes hemopoietic growth factors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7858491-0#48#52#gene3562 48-52 gene3562 denotes IL-3
7858491-0#54#59#gene1435 54-59 gene1435 denotes M-CSF
7858491-0#70#75#gene1436 70-75 gene1436 denotes C-FMS
7858491-0#108#113#gene1958 108-113 gene1958 denotes EGR-1
7858491-0#119#124#gene1435 119-124 gene1435 denotes M-CSF
7858491-0#142#167#diseaseC3463824 142-167 diseaseC3463824 denotes myelodysplastic syndromes
7858491-1#231#237#gene1437 400-406 gene1437 denotes GM-CSF
7858491-1#72#97#diseaseC3463824 241-266 diseaseC3463824 denotes myelodysplastic syndromes
7858491-1#99#102#diseaseC3463824 268-271 diseaseC3463824 denotes MDS
48#52#gene3562142#167#diseaseC3463824 7858491-0#48#52#gene3562 7858491-0#142#167#diseaseC3463824 associated_with IL-3,myelodysplastic syndromes
54#59#gene1435142#167#diseaseC3463824 7858491-0#54#59#gene1435 7858491-0#142#167#diseaseC3463824 associated_with M-CSF,myelodysplastic syndromes
70#75#gene1436142#167#diseaseC3463824 7858491-0#70#75#gene1436 7858491-0#142#167#diseaseC3463824 associated_with C-FMS,myelodysplastic syndromes
108#113#gene1958142#167#diseaseC3463824 7858491-0#108#113#gene1958 7858491-0#142#167#diseaseC3463824 associated_with EGR-1,myelodysplastic syndromes
119#124#gene1435142#167#diseaseC3463824 7858491-0#119#124#gene1435 7858491-0#142#167#diseaseC3463824 associated_with M-CSF,myelodysplastic syndromes
231#237#gene143772#97#diseaseC3463824 7858491-1#231#237#gene1437 7858491-1#72#97#diseaseC3463824 associated_with GM-CSF,myelodysplastic syndromes
231#237#gene143799#102#diseaseC3463824 7858491-1#231#237#gene1437 7858491-1#99#102#diseaseC3463824 associated_with GM-CSF,MDS

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-168 Sentence denotes Expression and genomic configuration of GM-CSF, IL-3, M-CSF receptor (C-FMS), early growth response gene-1 (EGR-1) and M-CSF genes in primary myelodysplastic syndromes.
S2 169-482 Sentence denotes Peripheral blood mononuclear cells from seventeen patients with primary myelodysplastic syndromes (MDS) in advanced stage were enriched for blasts and tested for (1) karyotype, (2) genomic configuration and (3) expression of IL-3, GM-CSF, FMS and EGR-1 genes which are all located on the long arm of chromosome 5.
S3 483-612 Sentence denotes The expression of the M-CSF gene, that has been recently reassigned to the short arm of chromosome 1 (lp), was also investigated.
S4 613-917 Sentence denotes Aims of the study were to (1) assess the potential role of the expression of these genes in the maintenance and expansion of the neoplastic clones and (2) search for constitutional losses or rearrangements of one allele followed by a deletion of the second allele of the same genes in the leukemic cells.
S5 918-1035 Sentence denotes The latter issue was investigated by comparing, in 8 cases, constitutive DNA from skin fibroblasts with leukemic DNA.
S6 1036-1086 Sentence denotes Eleven of the 17 patients had abnormal karyotypes.
S7 1087-1199 Sentence denotes The M-CSF gene was expressed in 6 cases and the FMS and the EGR-1 genes were expressed in 2 of the latter cases.
S8 1200-1330 Sentence denotes An autocrine mechanism of growth could be hypothesized only for the 2 patients whose cells expressed both the M-CSF and FMS genes.
S9 1331-1411 Sentence denotes No germline changes or rearrangements were observed in any of the genes studied.
S10 1412-1565 Sentence denotes Thus, deregulation of genes encoding for certain hemopoietic growth factors or receptors does not seem to represent a major mechanism of MDS progression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 54-76 NP denotes M-CSF receptor (C-FMS)
C3 78-114 NP denotes early growth response gene-1 (EGR-1)
C4 119-130 NP denotes M-CSF genes
C1 40-130 NP denotes GM-CSF, IL-3, M-CSF receptor (C-FMS), early growth response gene-1 (EGR-1) and M-CSF genes
C5 134-167 NP denotes primary myelodysplastic syndromes
C7 233-272 NP denotes primary myelodysplastic syndromes (MDS)
C6 209-290 NP denotes seventeen patients with primary myelodysplastic syndromes (MDS) in advanced stage
C9 331-344 NP denotes (1) karyotype
C11 416-427 NP denotes EGR-1 genes
C10 394-427 NP denotes IL-3, GM-CSF, FMS and EGR-1 genes
C8 331-427 NP denotes (1) karyotype, (2) genomic configuration and (3) expression of IL-3, GM-CSF, FMS and EGR-1 genes
C12 428-433 NP denotes which
C14 501-515 NP denotes the M-CSF gene
C13 483-515 NP denotes The expression of the M-CSF gene
C15 517-521 NP denotes that
C16 690-701 NP denotes these genes
C17 880-894 NP denotes the same genes
C18 1046-1061 NP denotes the 17 patients
C19 1075-1085 NP denotes karyotypes
C20 1087-1101 NP denotes The M-CSF gene
C21 1131-1138 NP denotes the FMS
C22 1143-1158 NP denotes the EGR-1 genes
C23 1177-1198 NP denotes 2 of the latter cases
C24 1264-1278 NP denotes the 2 patients
C25 1279-1284 NP denotes whose
C26 1393-1402 NP denotes the genes
R1 C7 C5 coref-ident primary myelodysplastic syndromes (MDS),primary myelodysplastic syndromes
R2 C11 C3 coref-ident EGR-1 genes,early growth response gene-1 (EGR-1)
R3 C10 C1 coref-ident "IL-3, GM-CSF, FMS and EGR-1 genes","GM-CSF, IL-3, M-CSF receptor (C-FMS), early growth response gene-1 (EGR-1) and M-CSF genes"
R4 C12 C8 coref-relat which,"(1) karyotype, (2) genomic configuration and (3) expression of IL-3, GM-CSF, FMS and EGR-1 genes"
R5 C14 C4 coref-ident the M-CSF gene,M-CSF genes
R6 C15 C13 coref-relat that,The expression of the M-CSF gene
R7 C16 C10 coref-ident these genes,"IL-3, GM-CSF, FMS and EGR-1 genes"
R8 C17 C16 coref-ident the same genes,these genes
R9 C18 C6 coref-ident the 17 patients,seventeen patients with primary myelodysplastic syndromes (MDS) in advanced stage
R10 C19 C9 coref-ident karyotypes,(1) karyotype
R11 C20 C14 coref-ident The M-CSF gene,the M-CSF gene
R12 C21 C2 coref-ident the FMS,M-CSF receptor (C-FMS)
R13 C22 C11 coref-ident the EGR-1 genes,EGR-1 genes
R14 C24 C23 coref-ident the 2 patients,2 of the latter cases
R15 C25 C24 coref-relat whose,the 2 patients
R16 C26 C10 coref-ident the genes,"IL-3, GM-CSF, FMS and EGR-1 genes"

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 40-46 protein_molecule denotes GM-CSF
T2 48-52 protein_molecule denotes IL-3
T3 54-68 protein_molecule denotes M-CSF receptor
T4 70-75 protein_molecule denotes C-FMS
T5 78-106 DNA_domain_or_region denotes early growth response gene-1
T6 108-113 DNA_domain_or_region denotes EGR-1
T7 119-130 DNA_domain_or_region denotes M-CSF genes
T8 134-167 other_name denotes primary myelodysplastic syndromes
T9 219-227 multi_cell denotes patients
T10 233-266 other_name denotes primary myelodysplastic syndromes
T11 268-271 other_name denotes MDS
T12 309-315 cell_type denotes blasts
T13 335-344 other_name denotes karyotype
T14 350-371 other_name denotes genomic configuration
T15 457-468 DNA_domain_or_region denotes long arm of
T16 469-481 DNA_molecule denotes chromosome 5
T17 505-515 DNA_domain_or_region denotes M-CSF gene
T18 558-570 DNA_domain_or_region denotes short arm of
T19 571-583 DNA_molecule denotes chromosome 1
T20 585-587 DNA_domain_or_region denotes lp
T21 742-759 cell_line denotes neoplastic clones
T22 826-832 DNA_domain_or_region denotes allele
T23 870-876 DNA_domain_or_region denotes allele
T24 902-916 cell_type denotes leukemic cells
T25 978-994 DNA_family_or_group denotes constitutive DNA
T26 1000-1016 cell_type denotes skin fibroblasts
T27 1022-1034 DNA_family_or_group denotes leukemic DNA
T28 1053-1061 multi_cell denotes patients
T29 1066-1085 other_name denotes abnormal karyotypes
T30 1091-1101 DNA_domain_or_region denotes M-CSF gene
T31 1135-1138 DNA_domain_or_region denotes FMS
T32 1147-1152 DNA_domain_or_region denotes EGR-1
T33 1270-1278 multi_cell denotes patients
T34 1461-1487 protein_family_or_group denotes hemopoietic growth factors
T35 1549-1552 other_name denotes MDS