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PubMed:7858261 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1372-1377 gene:4629 denotes MYH11
T1 1444-1447 disease:C0023467 denotes AML
T2 1372-1377 gene:4629 denotes MYH11
T3 1487-1490 disease:C0023467 denotes AML
T4 1372-1377 gene:4629 denotes MYH11
T5 1614-1617 disease:C0023467 denotes AML
R1 T0 T1 associated_with MYH11,AML
R2 T2 T3 associated_with MYH11,AML
R3 T4 T5 associated_with MYH11,AML

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 17-63 RNA denotes chromosome 16 CBF beta-MYH11 fusion transcript
T2 268-276 DNA denotes CBF beta
T3 281-286 DNA denotes MYH11
T4 317-335 RNA denotes fusion transcripts
T5 414-447 RNA denotes CBF beta-MYH11 fusion transcripts
T6 627-656 cell_type denotes atypical abnormal eosinophils
T7 777-785 DNA denotes CBF beta
T8 785-791 DNA denotes -MYH11
T9 983-1003 cell_type denotes abnormal eosinophils
T10 1009-1017 DNA denotes CBF beta
T11 1017-1023 DNA denotes -MYH11
T12 1071-1084 DNA denotes chromosome 16
T13 1177-1182 DNA denotes MYH11
T14 1363-1396 RNA denotes CBF beta-MYH11 fusion transcripts
T15 1583-1596 DNA denotes chromosome 16
T16 1673-1681 DNA denotes CBF beta
T17 1682-1699 RNA denotes MYH11 transcripts
T18 1727-1740 DNA denotes chromosome 16
T19 1992-2009 RNA denotes fusion transcript

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7858261-0#40#45#gene4629 40-45 gene4629 denotes MYH11
7858261-0#82#91#diseaseC0023418 82-91 diseaseC0023418 denotes leukemias
7858261-11#30#35#gene4629 1372-1377 gene4629 denotes MYH11
7858261-11#145#151#diseaseC0023479 1487-1493 diseaseC0023479 denotes AML M4
7858261-11#272#278#diseaseC0023479 1614-1620 diseaseC0023479 denotes AML M4
40#45#gene462982#91#diseaseC0023418 7858261-0#40#45#gene4629 7858261-0#82#91#diseaseC0023418 associated_with MYH11,leukemias
30#35#gene4629145#151#diseaseC0023479 7858261-11#30#35#gene4629 7858261-11#145#151#diseaseC0023479 associated_with MYH11,AML M4
30#35#gene4629272#278#diseaseC0023479 7858261-11#30#35#gene4629 7858261-11#272#278#diseaseC0023479 associated_with MYH11,AML M4

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-92 Sentence denotes Detection of the chromosome 16 CBF beta-MYH11 fusion transcript in myelomonocytic leukemias.
S2 93-200 Sentence denotes Karyotypic detection of chromosomal 16 abnormalities classically associated with AML M4Eo can be difficult.
S3 201-396 Sentence denotes Characterization of the two genes involved in the inv(16)(p13q22), CBF beta and MYH11, has allowed the detection of fusion transcripts by reverse-transcriptase polymerase chain reaction (RT-PCR).
S4 397-580 Sentence denotes We have analyzed CBF beta-MYH11 fusion transcripts by RT-PCR in myelomonocytic leukemias, with or without eosinophilia, to determine whether their presence correlates with morphology.
S5 581-747 Sentence denotes Fifty-three cases (11 AML M4Eo; 1 AML M4 with atypical abnormal eosinophils (AML M4 "Eo"); 29 AML M4; 8 AML M5; 3 CMML; and 1 AML M2 with eosinophilia) were analyzed.
S6 748-801 Sentence denotes All 11 typical AML M4Eo were CBF beta-MYH11 positive.
S7 802-949 Sentence denotes The single case of AML M4 with distinctive eosinophil abnormalities was negative by karyotype, RT-PCR and fluorescent in situ hybridization (FISH).
S8 950-1146 Sentence denotes Three of 29 (10%) AML M4 without abnormal eosinophils were CBF beta-MYH11 positive, 1 of which did not show any apparent chromosome 16 abnormalities by classical metaphase analysis (2 not tested).
S9 1147-1205 Sentence denotes Both cases tested also showed MYH11 genomic rearrangement.
S10 1206-1255 Sentence denotes None of the other leukemias were RT-PCR positive.
S11 1256-1341 Sentence denotes Follow-up of three patient showed residual positivity in apparent complete remission.
S12 1342-1635 Sentence denotes These data show that CBF beta-MYH11 fusion transcripts occur not only in the vast majority of typical AML M4Eo, but also in approximately 10% of AML M4 without eosinophilic abnormalities, a much higher incidence than the sporadic reports of chromosome 16 abnormalities in AML M4 would suggest.
S13 1636-2010 Sentence denotes Taken together with the detection of CBF beta-MYH11 transcripts in the absence of apparent chromosome 16 abnormalities by classical banding techniques, these data show that additional screening by either RT-PCR or FISH should be performed in all AML M4, regardless of morphologic features, to allow accurate evaluation of the prognostic importance of this fusion transcript.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 13-63 NP denotes the chromosome 16 CBF beta-MYH11 fusion transcript
C2 67-91 NP denotes myelomonocytic leukemias
C3 117-145 NP denotes chromosomal 16 abnormalities
C4 221-266 NP denotes the two genes involved in the inv(16)(p13q22)
C5 268-286 NP denotes CBF beta and MYH11
C6 339-395 NP denotes reverse-transcriptase polymerase chain reaction (RT-PCR)
C7 414-447 NP denotes CBF beta-MYH11 fusion transcripts
C8 451-457 NP denotes RT-PCR
C9 461-485 NP denotes myelomonocytic leukemias
C10 503-515 NP denotes eosinophilia
C11 538-543 NP denotes their
C12 748-771 NP denotes All 11 typical AML M4Eo
C13 777-800 NP denotes CBF beta-MYH11 positive
C14 897-903 NP denotes RT-PCR
C15 908-948 NP denotes fluorescent in situ hybridization (FISH)
C17 959-1003 NP denotes 29 (10%) AML M4 without abnormal eosinophils
C16 950-1003 NP denotes Three of 29 (10%) AML M4 without abnormal eosinophils
C18 1009-1032 NP denotes CBF beta-MYH11 positive
C19 1039-1044 NP denotes which
C20 1062-1098 NP denotes apparent chromosome 16 abnormalities
C21 1363-1396 NP denotes CBF beta-MYH11 fusion transcripts
C22 1436-1452 NP denotes typical AML M4Eo
C23 1466-1528 NP denotes approximately 10% of AML M4 without eosinophilic abnormalities
C24 1583-1610 NP denotes chromosome 16 abnormalities
C25 1673-1699 NP denotes CBF beta-MYH11 transcripts
C26 1718-1754 NP denotes apparent chromosome 16 abnormalities
C27 1840-1846 NP denotes RT-PCR
C28 1850-1854 NP denotes FISH
C29 1987-2009 NP denotes this fusion transcript
R1 C5 C4 coref-appos CBF beta and MYH11,the two genes involved in the inv(16)(p13q22)
R2 C7 C1 coref-ident CBF beta-MYH11 fusion transcripts,the chromosome 16 CBF beta-MYH11 fusion transcript
R3 C8 C6 coref-ident RT-PCR,reverse-transcriptase polymerase chain reaction (RT-PCR)
R4 C9 C2 coref-ident myelomonocytic leukemias,myelomonocytic leukemias
R5 C11 C10 coref-pron their,eosinophilia
R6 C18 C13 coref-ident CBF beta-MYH11 positive,CBF beta-MYH11 positive
R7 C19 C16 coref-relat which,Three of 29 (10%) AML M4 without abnormal eosinophils
R8 C20 C3 coref-ident apparent chromosome 16 abnormalities,chromosomal 16 abnormalities
R9 C21 C7 coref-ident CBF beta-MYH11 fusion transcripts,CBF beta-MYH11 fusion transcripts
R10 C22 C12 coref-ident typical AML M4Eo,All 11 typical AML M4Eo
R11 C23 C17 coref-ident approximately 10% of AML M4 without eosinophilic abnormalities,29 (10%) AML M4 without abnormal eosinophils
R12 C24 C20 coref-ident chromosome 16 abnormalities,apparent chromosome 16 abnormalities
R13 C25 C21 coref-ident CBF beta-MYH11 transcripts,CBF beta-MYH11 fusion transcripts
R14 C26 C24 coref-ident apparent chromosome 16 abnormalities,chromosome 16 abnormalities
R15 C27 C14 coref-ident RT-PCR,RT-PCR
R16 C28 C15 coref-ident FISH,fluorescent in situ hybridization (FISH)
R17 C29 C25 coref-ident this fusion transcript,CBF beta-MYH11 transcripts

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 17-30 DNA_molecule denotes chromosome 16
T2 67-91 other_name denotes myelomonocytic leukemias
T3 117-145 other_name denotes chromosomal 16 abnormalities
T4 174-182 other_name denotes AML M4Eo
T5 251-266 other_name denotes inv(16)(p13q22)
T6 268-276 DNA_domain_or_region denotes CBF beta
T7 281-286 DNA_domain_or_region denotes MYH11
T8 317-335 RNA_family_or_group denotes fusion transcripts
T9 339-386 other_name denotes reverse-transcriptase polymerase chain reaction
T10 388-394 other_name denotes RT-PCR
T11 414-422 DNA_domain_or_region denotes CBF beta
T12 422-428 DNA_domain_or_region denotes -MYH11
T13 451-457 other_name denotes RT-PCR
T14 461-485 other_name denotes myelomonocytic leukemias
T15 503-515 other_name denotes eosinophilia
T16 603-611 other_name denotes AML M4Eo
T17 615-621 other_name denotes AML M4
T18 627-656 cell_type denotes atypical abnormal eosinophils
T19 675-681 other_name denotes AML M4
T20 685-691 other_name denotes AML M5
T21 695-699 other_name denotes CMML
T22 707-713 other_name denotes AML M2
T23 719-731 other_name denotes eosinophilia
T24 763-771 other_name denotes AML M4Eo
T25 777-785 DNA_domain_or_region denotes CBF beta
T26 785-791 DNA_domain_or_region denotes -MYH11
T27 821-827 other_name denotes AML M4
T28 845-869 other_name denotes eosinophil abnormalities
T29 886-895 other_name denotes karyotype
T30 897-903 other_name denotes RT-PCR
T31 908-941 other_name denotes fluorescent in situ hybridization
T32 943-947 other_name denotes FISH
T33 968-974 other_name denotes AML M4
T34 983-1003 cell_type denotes abnormal eosinophils
T35 1009-1017 DNA_domain_or_region denotes CBF beta
T36 1017-1023 DNA_domain_or_region denotes -MYH11
T37 1071-1084 DNA_molecule denotes chromosome 16
T38 1102-1130 other_name denotes classical metaphase analysis
T39 1177-1182 DNA_domain_or_region denotes MYH11
T40 1224-1233 other_name denotes leukemias
T41 1239-1245 other_name denotes RT-PCR
T42 1363-1371 DNA_domain_or_region denotes CBF beta
T43 1371-1377 DNA_domain_or_region denotes -MYH11
T44 1444-1452 other_name denotes AML M4Eo
T45 1487-1493 other_name denotes AML M4
T46 1502-1528 other_name denotes eosinophilic abnormalities
T47 1583-1596 DNA_molecule denotes chromosome 16
T48 1614-1620 other_name denotes AML M4
T49 1673-1681 DNA_domain_or_region denotes CBF beta
T50 1682-1687 DNA_domain_or_region denotes MYH11
T51 1727-1740 DNA_molecule denotes chromosome 16
T52 1840-1846 other_name denotes RT-PCR
T53 1850-1854 other_name denotes FISH
T54 1882-1888 other_name denotes AML M4
T55 1992-2009 RNA_family_or_group denotes fusion transcript