PubMed:7843230
Annnotations
MyTest
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T10 | 524-527 | Protein | denotes | p50 | uniprot:P19838 |
| T12 | 528-531 | Protein | denotes | p65 | uniprot:Q04206 |
| T14 | 559-562 | Protein | denotes | p50 | uniprot:P19838 |
| T16 | 563-568 | Protein | denotes | c-rel | uniprot:Q04864 |
| T17 | 1091-1118 | Protein | denotes | tumor necrosis factor alpha | P01375 |
| T18 | 1163-1176 | Chemical | denotes | cycloheximide | mesh:D003513 |
| T19 | 815-818 | Protein | denotes | p65 | uniprot:Q04206 |
| T20 | 933-936 | Protein | denotes | p65 | uniprot:Q04206 |
| T21 | 1191-1194 | Protein | denotes | p65 | uniprot:Q04206 |
| T22 | 905-908 | Protein | denotes | p50 | uniprot:P19838 |
| T23 | 1848-1851 | Protein | denotes | p50 | uniprot:P19838 |
| T25 | 823-828 | Protein | denotes | c-rel | uniprot:Q04864 |
| T26 | 890-895 | Protein | denotes | c-rel | uniprot:Q04864 |
| T27 | 1199-1204 | Protein | denotes | c-rel | uniprot:Q04864 |
| T28 | 1833-1838 | Protein | denotes | c-rel | uniprot:Q04864 |
| T3 | 1791-1794 | Protein | denotes | p65 | |
| T30 | 1397-1406 | Protein | denotes | TNF-alpha | uniprot:P01375 |
| T31 | 1120-1129 | Protein | denotes | TNF-alpha | uniprot:P01375 |
| T32 | 1629-1638 | Protein | denotes | TNF-alpha | uniprot:P01375 |
| T33 | 238-245 | Cell | denotes | T cells | |
| T4 | 1799-1804 | Protein | denotes | c-rel | |
| T5 | 1651-1660 | Protein | denotes | TNF-alpha | uniprot:P01375 |
| T7 | 303-306 | Protein | denotes | p50 | uniprot:P19838 |
| T8 | 355-391 | Protein | denotes | interleukin-2 receptor (IL-2R) alpha | uniprot:P01589 |
| T35 | 1479-1489 | Protein_complex | denotes | NF-kappa B | wikipedia:NF-κB |
| T36 | 307-317 | Protein_complex | denotes | NF-kappa B | wikipedia:NF-κB |
| T37 | 1734-1744 | Protein_complex | denotes | NF-kappa B | wikipedia:NF-κB |
| T39 | 20-42 | Protein_complex | denotes | nuclear factor-kappa B | wikipedia:NF-κB |
| T41 | 141-168 | Protein_complex | denotes | nuclear factor (NF)-kappa B | wikipedia:NF-κB |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-42 | protein | denotes | nuclear factor-kappa B |
| T2 | 61-84 | protein | denotes | T cell receptor complex |
| T3 | 94-121 | protein | denotes | tumor necrosis factor alpha |
| T4 | 141-168 | protein | denotes | nuclear factor (NF)-kappa B |
| T5 | 187-220 | protein | denotes | T cell receptor (TcR)/CD3 complex |
| T6 | 238-245 | cell_type | denotes | T cells |
| T7 | 303-325 | protein | denotes | p50 NF-kappa B protein |
| T8 | 336-351 | DNA | denotes | kappa B element |
| T9 | 355-406 | DNA | denotes | interleukin-2 receptor (IL-2R) alpha chain promoter |
| T10 | 418-425 | cell_type | denotes | T cells |
| T11 | 454-461 | protein | denotes | TcR/CD3 |
| T12 | 524-544 | protein | denotes | p50.p65 heterodimers |
| T13 | 559-581 | protein | denotes | p50.c-rel heterodimers |
| T14 | 815-818 | protein | denotes | p65 |
| T15 | 823-828 | protein | denotes | c-rel |
| T16 | 933-941 | RNA | denotes | p65 mRNA |
| T17 | 1086-1150 | protein | denotes | anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody |
| T18 | 1191-1194 | protein | denotes | p65 |
| T19 | 1199-1204 | protein | denotes | c-rel |
| T20 | 1397-1406 | protein | denotes | TNF-alpha |
| T21 | 1479-1489 | protein | denotes | NF-kappa B |
| T22 | 1529-1536 | protein | denotes | TcR/CD3 |
| T23 | 1558-1565 | protein | denotes | TcR/CD3 |
| T24 | 1629-1638 | protein | denotes | TNF-alpha |
| T25 | 1651-1660 | protein | denotes | TNF-alpha |
| T26 | 1734-1744 | protein | denotes | NF-kappa B |
| T27 | 1791-1794 | protein | denotes | p65 |
| T28 | 1799-1804 | protein | denotes | c-rel |
| T29 | 1814-1818 | RNA | denotes | mRNA |
| T30 | 1833-1838 | protein | denotes | c-rel |
| T31 | 1843-1851 | protein | denotes | p105/p50 |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 57-84 | NP | denotes | the T cell receptor complex |
| C1 | 20-84 | NP | denotes | nuclear factor-kappa B activation by the T cell receptor complex |
| C3 | 94-121 | NP | denotes | tumor necrosis factor alpha |
| C6 | 183-220 | NP | denotes | the T cell receptor (TcR)/CD3 complex |
| C5 | 141-220 | NP | denotes | nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex |
| C4 | 123-220 | NP | denotes | The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex |
| C7 | 286-296 | NP | denotes | activation |
| C8 | 524-544 | NP | denotes | p50.p65 heterodimers |
| C9 | 559-581 | NP | denotes | p50.c-rel heterodimers |
| C10 | 666-670 | NP | denotes | both |
| C11 | 727-737 | NP | denotes | activation |
| C12 | 790-828 | NP | denotes | nuclear translocation of p65 and c-rel |
| C13 | 866-876 | NP | denotes | Activation |
| C14 | 890-923 | NP | denotes | c-rel and p105/p50 mRNA synthesis |
| C15 | 933-941 | NP | denotes | p65 mRNA |
| C16 | 942-947 | NP | denotes | whose |
| C17 | 1187-1218 | NP | denotes | the p65 and c-rel translocation |
| C18 | 1397-1406 | NP | denotes | TNF-alpha |
| C20 | 1479-1500 | NP | denotes | NF-kappa B activation |
| C19 | 1461-1500 | NP | denotes | the regulation of NF-kappa B activation |
| C21 | 1529-1544 | NP | denotes | TcR/CD3 signals |
| C22 | 1558-1565 | NP | denotes | TcR/CD3 |
| C24 | 1575-1578 | NP | denotes | its |
| C23 | 1575-1602 | NP | denotes | its immediate translocation |
| C25 | 1604-1609 | NP | denotes | which |
| C26 | 1629-1638 | NP | denotes | TNF-alpha |
| C27 | 1651-1660 | NP | denotes | TNF-alpha |
| C28 | 1734-1755 | NP | denotes | NF-kappa B regulation |
| C29 | 1769-1804 | NP | denotes | both translocation of p65 and c-rel |
| C30 | 1810-1851 | NP | denotes | new mRNA synthesis for c-rel and p105/p50 |
| R1 | C6 | C2 | coref-ident | the T cell receptor (TcR)/CD3 complex,the T cell receptor complex |
| R2 | C5 | C1 | coref-ident | nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex,nuclear factor-kappa B activation by the T cell receptor complex |
| R3 | C7 | C5 | coref-ident | activation,nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex |
| R4 | C10 | C8 | coref-pron | both,p50.p65 heterodimers |
| R5 | C10 | C9 | coref-pron | both,p50.c-rel heterodimers |
| R6 | C11 | C7 | coref-ident | activation,activation |
| R7 | C13 | C11 | coref-ident | Activation,activation |
| R8 | C16 | C15 | coref-relat | whose,p65 mRNA |
| R9 | C17 | C12 | coref-ident | the p65 and c-rel translocation,nuclear translocation of p65 and c-rel |
| R10 | C18 | C3 | coref-ident | TNF-alpha,tumor necrosis factor alpha |
| R11 | C20 | C5 | coref-ident | NF-kappa B activation,nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex |
| R12 | C19 | C4 | coref-ident | the regulation of NF-kappa B activation,The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex |
| R13 | C22 | C21 | coref-ident | TcR/CD3,TcR/CD3 signals |
| R14 | C24 | C20 | coref-pron | its,NF-kappa B activation |
| R15 | C25 | C23 | coref-relat | which,its immediate translocation |
| R16 | C26 | C18 | coref-ident | TNF-alpha,TNF-alpha |
| R17 | C27 | C26 | coref-ident | TNF-alpha,TNF-alpha |
| R18 | C28 | C19 | coref-ident | NF-kappa B regulation,the regulation of NF-kappa B activation |
| R19 | C29 | C17 | coref-ident | both translocation of p65 and c-rel,the p65 and c-rel translocation |
| R20 | C30 | C14 | coref-ident | new mRNA synthesis for c-rel and p105/p50,c-rel and p105/p50 mRNA synthesis |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-122 | Sentence | denotes | Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha. |
| S2 | 123-297 | Sentence | denotes | The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation. |
| S3 | 298-426 | Sentence | denotes | Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells. |
| S4 | 427-558 | Sentence | denotes | However, immediately after TcR/CD3 cross-linking (after approximately 1 h; immediate) binding of p50.p65 heterodimers was observed. |
| S5 | 559-738 | Sentence | denotes | p50.c-rel heterodimers were also detected bound to this sequence at early time points (7-16 h; early), and both remained active at later time points (40 h; late) after activation. |
| S6 | 739-865 | Sentence | denotes | This regulation takes place mainly at the level of nuclear translocation of p65 and c-rel, at immediate and early time points. |
| S7 | 866-976 | Sentence | denotes | Activation also induced c-rel and p105/p50 mRNA synthesis, but not p65 mRNA whose expression was constitutive. |
| S8 | 977-1151 | Sentence | denotes | Interestingly, all those early and late events, but not the immediate ones, were inhibited by a neutralizing anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody. |
| S9 | 1152-1300 | Sentence | denotes | Similarly, cycloheximide prevented the p65 and c-rel translocation and consequent formation of active binding heterodimers, at early and late times. |
| S10 | 1301-1432 | Sentence | denotes | Cyclosporin A impaired not only early and late, but also immediate events; however, addition of TNF-alpha prevented all inhibition. |
| S11 | 1433-1650 | Sentence | denotes | These results indicate that the regulation of NF-kappa B activation during T cell activation by TcR/CD3 signals is biphasic: TcR/CD3 triggers its immediate translocation, which is transient if no TNF-alpha is present. |
| S12 | 1651-1852 | Sentence | denotes | TNF-alpha, therefore, emerges as the main factor responsible for a second phase of NF-kappa B regulation, controlling both translocation of p65 and c-rel, and new mRNA synthesis for c-rel and p105/p50. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-42 | protein_molecule | denotes | nuclear factor-kappa B |
| T2 | 61-84 | protein_complex | denotes | T cell receptor complex |
| T3 | 94-121 | protein_molecule | denotes | tumor necrosis factor alpha |
| T4 | 141-168 | protein_molecule | denotes | nuclear factor (NF)-kappa B |
| T5 | 187-202 | protein_complex | denotes | T cell receptor |
| T6 | 238-245 | cell_type | denotes | T cells |
| T7 | 303-325 | protein_molecule | denotes | p50 NF-kappa B protein |
| T8 | 336-351 | DNA_domain_or_region | denotes | kappa B element |
| T9 | 355-377 | protein_molecule | denotes | interleukin-2 receptor |
| T10 | 379-384 | protein_molecule | denotes | IL-2R |
| T11 | 418-425 | cell_type | denotes | T cells |
| T12 | 454-461 | protein_complex | denotes | TcR/CD3 |
| T13 | 524-544 | protein_complex | denotes | p50.p65 heterodimers |
| T14 | 559-581 | protein_complex | denotes | p50.c-rel heterodimers |
| T15 | 790-811 | other_name | denotes | nuclear translocation |
| T16 | 815-818 | protein_subunit | denotes | p65 |
| T17 | 823-828 | protein_subunit | denotes | c-rel |
| T18 | 933-936 | protein_subunit | denotes | p65 |
| T19 | 1086-1091 | protein_molecule | denotes | anti- |
| T20 | 1091-1118 | protein_molecule | denotes | tumor necrosis factor alpha |
| T21 | 1191-1194 | protein_subunit | denotes | p65 |
| T22 | 1199-1204 | protein_subunit | denotes | c-rel |
| T23 | 1205-1218 | other_name | denotes | translocation |
| T24 | 1301-1314 | other_organic_compound | denotes | Cyclosporin A |
| T25 | 1397-1406 | protein_molecule | denotes | TNF-alpha |
| T26 | 1479-1489 | protein_molecule | denotes | NF-kappa B |
| T27 | 1508-1525 | other_name | denotes | T cell activation |
| T28 | 1529-1536 | protein_complex | denotes | TcR/CD3 |
| T29 | 1558-1565 | protein_complex | denotes | TcR/CD3 |
| T30 | 1629-1638 | protein_molecule | denotes | TNF-alpha |
| T31 | 1651-1660 | protein_molecule | denotes | TNF-alpha |
| T32 | 1734-1744 | protein_molecule | denotes | NF-kappa B |
| T33 | 1791-1794 | protein_subunit | denotes | p65 |
| T34 | 1799-1804 | protein_subunit | denotes | c-rel |
| T35 | 1814-1818 | RNA_family_or_group | denotes | mRNA |
| T36 | 1833-1838 | protein_subunit | denotes | c-rel |
| T37 | 1843-1851 | protein_complex | denotes | p105/p50 |