> top > docs > PubMed:7833370 > annotations

PubMed:7833370 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-252 Sentence denotes Evaluation of the respiratory epithelium of normals and individuals with cystic fibrosis for the presence of adenovirus E1a sequences relevant to the use of E1a- adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibrosis.
T2 253-500 Sentence denotes Lung disease associated with disorders such as cystic fibrosis (CF) may be amenable to somatic gene therapy in which there is delivery of the normal gene directly to the respiratory epithelium using E1a- adenovirus (Ad) type 2- or 5-based vectors.
T3 501-601 Sentence denotes For safety reasons, the Ad vectors are rendered replication deficient by deletion of the E1a region.
T4 602-934 Sentence denotes Because there is the theoretical possibility of an E1a- replication-deficient vector replicating as a result of recombination or complementation with Ad 2/5 E1a sequences present in the target cell, this study is directed toward evaluating respiratory epithelium of normals and individuals with CF for the presence of E1a sequences.
T5 935-1185 Sentence denotes Using Ad 2/5 E1a-specific primers and the polymerase chain reaction to evaluate DNA recovered from freshly isolated nasal and bronchial epithelium recovered by brushing, E1a sequences were detected in respiratory epithelium of 19 of 91 normals (21%).
T6 1186-1282 Sentence denotes In the E1a-positive samples, the average of E1a copy number was 55 +/- 18/10(3) recovered cells.
T7 1283-1456 Sentence denotes In CF individuals, 7 of 52 (13%) had detectable E1a sequences in the respiratory epithelium, with E1a copy number in the positive samples of 80 +/- 21/10(3) recovered cells.
T8 1457-1617 Sentence denotes These results demonstrate that there are detectable Ad 2/5 E1a sequences in the respiratory epithelium of a small percentage of normals and individuals with CF.
T9 1618-1891 Sentence denotes Because of the theoretical potential of such sequences supporting replication of E1a- Ad vectors, human gene therapy protocols for CF utilizing such vectors should consider evaluating study individuals for the presence of Ad 2/5 E1a sequences in the respiratory epithelium.
T1 0-252 Sentence denotes Evaluation of the respiratory epithelium of normals and individuals with cystic fibrosis for the presence of adenovirus E1a sequences relevant to the use of E1a- adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibrosis.
T2 253-500 Sentence denotes Lung disease associated with disorders such as cystic fibrosis (CF) may be amenable to somatic gene therapy in which there is delivery of the normal gene directly to the respiratory epithelium using E1a- adenovirus (Ad) type 2- or 5-based vectors.
T3 501-601 Sentence denotes For safety reasons, the Ad vectors are rendered replication deficient by deletion of the E1a region.
T4 602-934 Sentence denotes Because there is the theoretical possibility of an E1a- replication-deficient vector replicating as a result of recombination or complementation with Ad 2/5 E1a sequences present in the target cell, this study is directed toward evaluating respiratory epithelium of normals and individuals with CF for the presence of E1a sequences.
T5 935-1185 Sentence denotes Using Ad 2/5 E1a-specific primers and the polymerase chain reaction to evaluate DNA recovered from freshly isolated nasal and bronchial epithelium recovered by brushing, E1a sequences were detected in respiratory epithelium of 19 of 91 normals (21%).
T6 1186-1282 Sentence denotes In the E1a-positive samples, the average of E1a copy number was 55 +/- 18/10(3) recovered cells.
T7 1283-1456 Sentence denotes In CF individuals, 7 of 52 (13%) had detectable E1a sequences in the respiratory epithelium, with E1a copy number in the positive samples of 80 +/- 21/10(3) recovered cells.
T8 1457-1617 Sentence denotes These results demonstrate that there are detectable Ad 2/5 E1a sequences in the respiratory epithelium of a small percentage of normals and individuals with CF.
T9 1618-1891 Sentence denotes Because of the theoretical potential of such sequences supporting replication of E1a- Ad vectors, human gene therapy protocols for CF utilizing such vectors should consider evaluating study individuals for the presence of Ad 2/5 E1a sequences in the respiratory epithelium.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 109-133 DNA denotes adenovirus E1a sequences
T2 395-406 DNA denotes normal gene
T3 590-600 DNA denotes E1a region
T4 752-772 DNA denotes Ad 2/5 E1a sequences
T5 941-968 DNA denotes Ad 2/5 E1a-specific primers
T6 1105-1118 DNA denotes E1a sequences
T7 1331-1344 DNA denotes E1a sequences
T8 1509-1529 DNA denotes Ad 2/5 E1a sequences
T9 1840-1860 DNA denotes Ad 2/5 E1a sequences

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 44-51 NP denotes normals
C4 73-88 NP denotes cystic fibrosis
C3 56-88 NP denotes individuals with cystic fibrosis
C1 14-88 NP denotes the respiratory epithelium of normals and individuals with cystic fibrosis
C5 109-133 NP denotes adenovirus E1a sequences
C6 236-251 NP denotes cystic fibrosis
C7 300-320 NP denotes cystic fibrosis (CF)
C8 340-360 NP denotes somatic gene therapy
C9 364-369 NP denotes which
C10 452-499 NP denotes E1a- adenovirus (Ad) type 2- or 5-based vectors
C11 521-535 NP denotes the Ad vectors
C12 752-772 NP denotes Ad 2/5 E1a sequences
C14 868-875 NP denotes normals
C16 897-899 NP denotes CF
C15 880-899 NP denotes individuals with CF
C13 842-899 NP denotes respiratory epithelium of normals and individuals with CF
C17 920-933 NP denotes E1a sequences
C18 1105-1118 NP denotes E1a sequences
C19 1286-1300 NP denotes CF individuals
C20 1331-1344 NP denotes E1a sequences
C21 1498-1529 NP denotes detectable Ad 2/5 E1a sequences
C23 1614-1616 NP denotes CF
C22 1533-1616 NP denotes the respiratory epithelium of a small percentage of normals and individuals with CF
C24 1658-1672 NP denotes such sequences
C25 1699-1714 NP denotes E1a- Ad vectors
C26 1749-1751 NP denotes CF
C27 1762-1774 NP denotes such vectors
C28 1840-1860 NP denotes Ad 2/5 E1a sequences
R1 C6 C4 coref-ident cystic fibrosis,cystic fibrosis
R2 C9 C8 coref-relat which,somatic gene therapy
R3 C11 C10 coref-ident the Ad vectors,E1a- adenovirus (Ad) type 2- or 5-based vectors
R4 C12 C5 coref-ident Ad 2/5 E1a sequences,adenovirus E1a sequences
R5 C14 C2 coref-ident normals,normals
R6 C16 C7 coref-ident CF,cystic fibrosis (CF)
R7 C15 C3 coref-ident individuals with CF,individuals with cystic fibrosis
R8 C13 C1 coref-ident respiratory epithelium of normals and individuals with CF,the respiratory epithelium of normals and individuals with cystic fibrosis
R9 C18 C17 coref-ident E1a sequences,E1a sequences
R10 C19 C15 coref-ident CF individuals,individuals with CF
R11 C20 C18 coref-ident E1a sequences,E1a sequences
R12 C21 C12 coref-ident detectable Ad 2/5 E1a sequences,Ad 2/5 E1a sequences
R13 C23 C16 coref-ident CF,CF
R14 C22 C13 coref-ident the respiratory epithelium of a small percentage of normals and individuals with CF,respiratory epithelium of normals and individuals with CF
R15 C24 C21 coref-ident such sequences,detectable Ad 2/5 E1a sequences
R16 C25 C10 coref-ident E1a- Ad vectors,E1a- adenovirus (Ad) type 2- or 5-based vectors
R17 C26 C23 coref-ident CF,CF
R18 C27 C25 coref-ident such vectors,E1a- Ad vectors
R19 C28 C12 coref-ident Ad 2/5 E1a sequences,Ad 2/5 E1a sequences

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-252 Sentence denotes Evaluation of the respiratory epithelium of normals and individuals with cystic fibrosis for the presence of adenovirus E1a sequences relevant to the use of E1a- adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibrosis.
S2 253-500 Sentence denotes Lung disease associated with disorders such as cystic fibrosis (CF) may be amenable to somatic gene therapy in which there is delivery of the normal gene directly to the respiratory epithelium using E1a- adenovirus (Ad) type 2- or 5-based vectors.
S3 501-601 Sentence denotes For safety reasons, the Ad vectors are rendered replication deficient by deletion of the E1a region.
S4 602-934 Sentence denotes Because there is the theoretical possibility of an E1a- replication-deficient vector replicating as a result of recombination or complementation with Ad 2/5 E1a sequences present in the target cell, this study is directed toward evaluating respiratory epithelium of normals and individuals with CF for the presence of E1a sequences.
S5 935-1185 Sentence denotes Using Ad 2/5 E1a-specific primers and the polymerase chain reaction to evaluate DNA recovered from freshly isolated nasal and bronchial epithelium recovered by brushing, E1a sequences were detected in respiratory epithelium of 19 of 91 normals (21%).
S6 1186-1282 Sentence denotes In the E1a-positive samples, the average of E1a copy number was 55 +/- 18/10(3) recovered cells.
S7 1283-1456 Sentence denotes In CF individuals, 7 of 52 (13%) had detectable E1a sequences in the respiratory epithelium, with E1a copy number in the positive samples of 80 +/- 21/10(3) recovered cells.
S8 1457-1617 Sentence denotes These results demonstrate that there are detectable Ad 2/5 E1a sequences in the respiratory epithelium of a small percentage of normals and individuals with CF.
S9 1618-1891 Sentence denotes Because of the theoretical potential of such sequences supporting replication of E1a- Ad vectors, human gene therapy protocols for CF utilizing such vectors should consider evaluating study individuals for the presence of Ad 2/5 E1a sequences in the respiratory epithelium.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-40 tissue denotes respiratory epithelium
T2 73-88 other_name denotes cystic fibrosis
T3 109-133 DNA_domain_or_region denotes adenovirus E1a sequences
T4 157-180 virus denotes E1a- adenovirus vectors
T5 185-197 other_name denotes gene therapy
T6 206-232 other_name denotes respiratory manifestations
T7 236-251 other_name denotes cystic fibrosis
T8 253-257 body_part denotes Lung
T9 300-315 other_name denotes cystic fibrosis
T10 340-360 other_name denotes somatic gene therapy
T11 395-406 DNA_family_or_group denotes normal gene
T12 423-445 tissue denotes respiratory epithelium
T13 452-480 virus denotes E1a- adenovirus (Ad) type 2-
T14 484-499 virus denotes 5-based vectors
T15 525-535 virus denotes Ad vectors
T16 549-570 other_name denotes replication deficient
T17 590-600 DNA_domain_or_region denotes E1a region
T18 653-686 virus denotes E1a- replication-deficient vector
T19 714-727 other_name denotes recombination
T20 731-746 other_name denotes complementation
T21 752-772 DNA_domain_or_region denotes Ad 2/5 E1a sequences
T22 842-864 tissue denotes respiratory epithelium
T23 868-875 multi_cell denotes normals
T24 880-891 multi_cell denotes individuals
T25 897-899 other_name denotes CF
T26 941-968 DNA_domain_or_region denotes Ad 2/5 E1a-specific primers
T27 977-1002 other_name denotes polymerase chain reaction
T28 1105-1118 DNA_domain_or_region denotes E1a sequences
T29 1136-1158 tissue denotes respiratory epithelium
T30 1171-1178 multi_cell denotes normals
T31 1193-1213 tissue denotes E1a-positive samples
T32 1230-1245 other_name denotes E1a copy number
T33 1286-1288 other_name denotes CF
T34 1289-1300 multi_cell denotes individuals
T35 1331-1344 DNA_domain_or_region denotes E1a sequences
T36 1352-1374 tissue denotes respiratory epithelium
T37 1381-1396 other_name denotes E1a copy number
T38 1509-1515 DNA_domain_or_region denotes Ad 2/5
T39 1516-1529 DNA_domain_or_region denotes E1a sequences
T40 1537-1559 tissue denotes respiratory epithelium
T41 1585-1592 multi_cell denotes normals
T42 1597-1608 multi_cell denotes individuals
T43 1614-1616 other_name denotes CF
T44 1699-1703 virus denotes E1a-
T45 1704-1714 virus denotes Ad vectors
T46 1749-1751 other_name denotes CF
T47 1808-1819 multi_cell denotes individuals
T48 1840-1846 DNA_domain_or_region denotes Ad 2/5
T49 1847-1860 DNA_domain_or_region denotes E1a sequences
T50 1868-1890 tissue denotes respiratory epithelium