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PubMed:7780199 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-147 Sentence denotes Treatment with the alpha-glucosidase 1 inhibitor 6-O-butanoyl castanospermine reduces the detection of LFA-1 (CD18/CD11a) by monoclonal antibodies.
TextSentencer_T2 148-330 Sentence denotes The antiviral clinical candidate 6-O-butanoyl castanospermine (MDL 28,574), an alpha-glucosidase 1 inhibitor, was examined for its effect on elementary parameters of immune function.
TextSentencer_T3 331-569 Sentence denotes It did not affect the mitogenic response of uninfected human mononuclear leukocytes or the detection of a range of cell surface markers, with the exception of the integrin LFA-1 (CD18/CD11a), which was reduced, after cell growth in vitro.
TextSentencer_T4 570-729 Sentence denotes The detection of LFA-1 was also reduced on both human and murine cells after oral administration of the compound to xenochimaeric or normal mice, respectively.
TextSentencer_T5 730-992 Sentence denotes Altered LFA-1 expression or function may contribute to reduced cell adhesion and the observed reduction in the in vitro allogeneic response by uninfected cells, as well as the previously described prevention of cell conjugate and HIV-induced syncytium formation.
T1 0-147 Sentence denotes Treatment with the alpha-glucosidase 1 inhibitor 6-O-butanoyl castanospermine reduces the detection of LFA-1 (CD18/CD11a) by monoclonal antibodies.
T2 148-330 Sentence denotes The antiviral clinical candidate 6-O-butanoyl castanospermine (MDL 28,574), an alpha-glucosidase 1 inhibitor, was examined for its effect on elementary parameters of immune function.
T3 331-569 Sentence denotes It did not affect the mitogenic response of uninfected human mononuclear leukocytes or the detection of a range of cell surface markers, with the exception of the integrin LFA-1 (CD18/CD11a), which was reduced, after cell growth in vitro.
T4 570-729 Sentence denotes The detection of LFA-1 was also reduced on both human and murine cells after oral administration of the compound to xenochimaeric or normal mice, respectively.
T5 730-992 Sentence denotes Altered LFA-1 expression or function may contribute to reduced cell adhesion and the observed reduction in the in vitro allogeneic response by uninfected cells, as well as the previously described prevention of cell conjugate and HIV-induced syncytium formation.
T1 0-147 Sentence denotes Treatment with the alpha-glucosidase 1 inhibitor 6-O-butanoyl castanospermine reduces the detection of LFA-1 (CD18/CD11a) by monoclonal antibodies.
T2 148-330 Sentence denotes The antiviral clinical candidate 6-O-butanoyl castanospermine (MDL 28,574), an alpha-glucosidase 1 inhibitor, was examined for its effect on elementary parameters of immune function.
T3 331-569 Sentence denotes It did not affect the mitogenic response of uninfected human mononuclear leukocytes or the detection of a range of cell surface markers, with the exception of the integrin LFA-1 (CD18/CD11a), which was reduced, after cell growth in vitro.
T4 570-729 Sentence denotes The detection of LFA-1 was also reduced on both human and murine cells after oral administration of the compound to xenochimaeric or normal mice, respectively.
T5 730-992 Sentence denotes Altered LFA-1 expression or function may contribute to reduced cell adhesion and the observed reduction in the in vitro allogeneic response by uninfected cells, as well as the previously described prevention of cell conjugate and HIV-induced syncytium formation.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 136-146 FMAID:167180 denotes antibodies
_T2 392-414 FMAID:167161 denotes mononuclear leukocytes
_T3 404-414 FMAID:167148 denotes leukocytes
_T4 404-414 FMAID:62852 denotes leukocytes
_T5 446-458 FMAID:200942 denotes cell surface
_T6 446-458 FMAID:212684 denotes cell surface
_T7 451-458 FMAID:146300 denotes surface
_T8 451-458 FMAID:50594 denotes surface
_T9 494-502 FMAID:67222 denotes integrin
_T10 494-502 FMAID:165244 denotes integrin
_T11 635-640 FMAID:169002 denotes cells
_T12 635-640 FMAID:68646 denotes cells
_T13 674-682 FMAID:165656 denotes compound
_T14 674-682 FMAID:67745 denotes compound
_T15 884-889 FMAID:169002 denotes cells
_T16 884-889 FMAID:68646 denotes cells

uniprot-human

Id Subject Object Predicate Lexical cue
T1 19-36 http://www.uniprot.org/uniprot/O43451 denotes alpha-glucosidase
T2 227-244 http://www.uniprot.org/uniprot/O43451 denotes alpha-glucosidase
T3 110-114 http://www.uniprot.org/uniprot/P05107 denotes CD18
T4 510-514 http://www.uniprot.org/uniprot/P05107 denotes CD18

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 25-38 http://www.uniprot.org/uniprot/Q80UM7 denotes glucosidase 1
T2 233-246 http://www.uniprot.org/uniprot/Q80UM7 denotes glucosidase 1
T3 110-114 http://www.uniprot.org/uniprot/P11835 denotes CD18
T4 510-514 http://www.uniprot.org/uniprot/P11835 denotes CD18

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 125-135 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T2 635-640 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 884-889 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 548-559 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T2 553-559 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3 793-806 http://purl.obolibrary.org/obo/GO_0007155 denotes cell adhesion
T4 946-955 http://purl.obolibrary.org/obo/GO_0000746 denotes conjugate
T5 972-991 http://purl.obolibrary.org/obo/GO_0006949 denotes syncytium formation
T6 982-991 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

GO-MF

Id Subject Object Predicate Lexical cue
T1 136-146 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies

GO-CC

Id Subject Object Predicate Lexical cue
T1 446-450 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 548-552 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 793-797 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 635-640 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 884-889 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 446-458 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 103-106 https://acgg.asia/db/lfdb/LfDB0086 denotes LFA
Lectin_T2 503-506 https://acgg.asia/db/lfdb/LfDB0086 denotes LFA
Lectin_T3 587-590 https://acgg.asia/db/lfdb/LfDB0086 denotes LFA
Lectin_T4 738-741 https://acgg.asia/db/lfdb/LfDB0086 denotes LFA

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 386-391 OrganismTaxon denotes human 9606
T2 618-623 OrganismTaxon denotes human 9606
T3 710-714 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 392-414 Body_part denotes mononuclear leukocytes http://purl.obolibrary.org/obo/CL_0000842
T2 972-981 Body_part denotes syncytium http://purl.obolibrary.org/obo/CL_0000228

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 392-414 Cell denotes mononuclear leukocytes http://purl.obolibrary.org/obo/CL:0000842
T2 972-981 Cell denotes syncytium http://purl.obolibrary.org/obo/CL:0000228