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PubMed:777027 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-66 Sentence denotes Hereditary deficiency of the fifth component of complement in man.
TextSentencer_T2 67-70 Sentence denotes II.
TextSentencer_T3 71-121 Sentence denotes Biological properties of C5-deficient human serum.
TextSentencer_T4 122-263 Sentence denotes The first known human kindred with hereditary deficiency of the fifth component of complement (C5) was documented in the accompanying report.
TextSentencer_T5 264-401 Sentence denotes This study examines several biological properties of C5-deficient (C5D) human serum, particularly sera obtained from two C5D homozygotes.
TextSentencer_T6 402-543 Sentence denotes The proband, who has inactive systemic lupus erythematosus is completely lacking C5, while her healthy half-sister has 1-2% of normal levels.
TextSentencer_T7 544-739 Sentence denotes Both sera were severely impaired in their ability to generate chemotactic activity for normal human neutrophils upon incubation with aggregated human gamma-globulin or Escherichia coli endotoxin.
TextSentencer_T8 740-919 Sentence denotes This function was fully restored in the sibling's serum, and substantially improved in the proband's serum, by addition of highly purified human C5 to normal serum concentrations.
TextSentencer_T9 920-1033 Sentence denotes Sera from eight family members who were apparently heterozygous for C5 deficiency gave normal chemotactic scores.
TextSentencer_T10 1034-1190 Sentence denotes The ability of C5D serum to opsonize Saccharomyces cerevisiae (baker's yeast) or Candida albicans for ingestion by normal neutrophils was completely normal.
TextSentencer_T11 1191-1310 Sentence denotes In addition, C5D serum was capable of promoting normal phagocytosis and intracellular killing of Staphylococcus aureus.
TextSentencer_T12 1311-1582 Sentence denotes The proband's serum was incapable of mediating lysis of erythrocytes from a patient with paroxysmal nocturnal hemoglobinuria in both the sucrose hemolysia and acid hemolysis tests, and also lacked bactericidal activity against sensitized or unsensitized Salmonella typhi.
TextSentencer_T13 1583-1734 Sentence denotes The sibling's serum, containing only 1-2% of normal C5, effectively lysed S. typhi, but only at eightfold lower serum dilutions as compared to normals.
TextSentencer_T14 1735-1957 Sentence denotes These findings underscore the critical role of C5 in the generation of chemotactic activity and in cytolytic reactions, as opposed to a nonobligatory or minimal role in opsonization, at least for the organisms under study.
T1 0-66 Sentence denotes Hereditary deficiency of the fifth component of complement in man.
T2 67-70 Sentence denotes II.
T3 71-121 Sentence denotes Biological properties of C5-deficient human serum.
T4 122-263 Sentence denotes The first known human kindred with hereditary deficiency of the fifth component of complement (C5) was documented in the accompanying report.
T5 264-401 Sentence denotes This study examines several biological properties of C5-deficient (C5D) human serum, particularly sera obtained from two C5D homozygotes.
T6 402-543 Sentence denotes The proband, who has inactive systemic lupus erythematosus is completely lacking C5, while her healthy half-sister has 1-2% of normal levels.
T7 544-739 Sentence denotes Both sera were severely impaired in their ability to generate chemotactic activity for normal human neutrophils upon incubation with aggregated human gamma-globulin or Escherichia coli endotoxin.
T8 740-919 Sentence denotes This function was fully restored in the sibling's serum, and substantially improved in the proband's serum, by addition of highly purified human C5 to normal serum concentrations.
T9 920-1033 Sentence denotes Sera from eight family members who were apparently heterozygous for C5 deficiency gave normal chemotactic scores.
T10 1034-1190 Sentence denotes The ability of C5D serum to opsonize Saccharomyces cerevisiae (baker's yeast) or Candida albicans for ingestion by normal neutrophils was completely normal.
T11 1191-1310 Sentence denotes In addition, C5D serum was capable of promoting normal phagocytosis and intracellular killing of Staphylococcus aureus.
T12 1311-1582 Sentence denotes The proband's serum was incapable of mediating lysis of erythrocytes from a patient with paroxysmal nocturnal hemoglobinuria in both the sucrose hemolysia and acid hemolysis tests, and also lacked bactericidal activity against sensitized or unsensitized Salmonella typhi.
T13 1583-1734 Sentence denotes The sibling's serum, containing only 1-2% of normal C5, effectively lysed S. typhi, but only at eightfold lower serum dilutions as compared to normals.
T14 1735-1957 Sentence denotes These findings underscore the critical role of C5 in the generation of chemotactic activity and in cytolytic reactions, as opposed to a nonobligatory or minimal role in opsonization, at least for the organisms under study.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 115-120 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 342-347 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 790-795 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 841-846 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 898-903 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 1053-1058 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T7 1208-1213 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T8 1325-1330 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T9 1597-1602 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T10 1695-1700 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T11 1935-1944 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 115-120 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 342-347 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 790-795 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 841-846 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 898-903 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 1053-1058 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T7 1208-1213 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T8 1325-1330 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T9 1597-1602 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T10 1695-1700 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T11 1935-1944 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 432-460 HP:0002725 denotes systemic lupus erythematosus
AB2 1400-1435 HP:0004818 denotes paroxysmal nocturnal hemoglobinuria

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 1400-1435 ORDO:447 denotes paroxysmal nocturnal hemoglobinuria

NCBIDiseaseCorpus

Id Subject Object Predicate Lexical cue
T1 0-58 SpecificDisease:OMIM:609536 denotes Hereditary deficiency of the fifth component of complement
T2 96-108 Modifier:OMIM:609536 denotes C5-deficient
T3 157-215 SpecificDisease:OMIM:609536 denotes hereditary deficiency of the fifth component of complement
T4 317-329 Modifier:OMIM:609536 denotes C5-deficient
T5 331-334 Modifier:OMIM:609536 denotes C5D
T6 385-388 Modifier:OMIM:609536 denotes C5D
T7 432-460 SpecificDisease:D008180 denotes systemic lupus erythematosus
T8 988-1001 SpecificDisease:OMIM:609536 denotes C5 deficiency
T9 1049-1052 Modifier:OMIM:609536 denotes C5D
T10 1204-1207 Modifier:OMIM:609536 denotes C5D
T11 1400-1435 SpecificDisease:D006457 denotes paroxysmal nocturnal hemoglobinuria

NCBI-Disease-Train

Id Subject Object Predicate Lexical cue database_id
T2579 0-58 SpecificDisease denotes Hereditary deficiency of the fifth component of complement OMIM:609536
T2580 96-108 Modifier denotes C5-deficient OMIM:609536
T2581 157-215 SpecificDisease denotes hereditary deficiency of the fifth component of complement OMIM:609536
T2582 317-329 Modifier denotes C5-deficient OMIM:609536
T2583 331-334 Modifier denotes C5D OMIM:609536
T2584 385-388 Modifier denotes C5D OMIM:609536
T2585 432-460 SpecificDisease denotes systemic lupus erythematosus D008180
T2586 988-1001 SpecificDisease denotes C5 deficiency OMIM:609536
T2587 1049-1052 Modifier denotes C5D OMIM:609536
T2588 1204-1207 Modifier denotes C5D OMIM:609536
T2589 1400-1435 SpecificDisease denotes paroxysmal nocturnal hemoglobinuria D006457

NCBI-Disease-Corpus-All

Id Subject Object Predicate Lexical cue database_id
T2579 0-58 SpecificDisease denotes Hereditary deficiency of the fifth component of complement OMIM:609536
T2580 96-108 Modifier denotes C5-deficient OMIM:609536
T2581 157-215 SpecificDisease denotes hereditary deficiency of the fifth component of complement OMIM:609536
T2582 317-329 Modifier denotes C5-deficient OMIM:609536
T2583 331-334 Modifier denotes C5D OMIM:609536
T2584 385-388 Modifier denotes C5D OMIM:609536
T2585 432-460 SpecificDisease denotes systemic lupus erythematosus D008180
T2586 988-1001 SpecificDisease denotes C5 deficiency OMIM:609536
T2587 1049-1052 Modifier denotes C5D OMIM:609536
T2588 1204-1207 Modifier denotes C5D OMIM:609536
T2589 1400-1435 SpecificDisease denotes paroxysmal nocturnal hemoglobinuria D006457

NCBI-Disease-Corpus-2stage-All

Id Subject Object Predicate Lexical cue
T1 157-215 SpecificDisease denotes hereditary deficiency of the fifth component of complement
T2 331-334 Modifier denotes C5D
T3 385-388 Modifier denotes C5D
T4 432-460 SpecificDisease denotes systemic lupus erythematosus
T5 988-1001 Modifier denotes C5 deficiency
T6 1049-1052 Modifier denotes C5D
T7 1204-1207 Modifier denotes C5D
T8 1400-1435 SpecificDisease denotes paroxysmal nocturnal hemoglobinuria
T9 1565-1581 Modifier denotes Salmonella typhi
T10 1657-1665 Modifier denotes S. typhi

NCBI-Disease-Corpus-rezarta-All

Id Subject Object Predicate Lexical cue
T1 317-329 Modifier denotes C5-deficient
T2 385-388 Modifier denotes C5D
T3 432-460 SpecificDisease denotes systemic lupus erythematosus
T4 483-485 SpecificDisease denotes C5
T5 885-887 Modifier denotes C5
T6 988-1001 Modifier denotes C5 deficiency
T7 1049-1052 Modifier denotes C5D
T8 1204-1207 Modifier denotes C5D
T9 1400-1435 SpecificDisease denotes paroxysmal nocturnal hemoglobinuria
T10 1565-1581 SpecificDisease denotes Salmonella typhi
T11 1635-1637 SpecificDisease denotes C5
T12 1657-1665 SpecificDisease denotes S. typhi
T13 1782-1784 SpecificDisease denotes C5

NCBI-Disease-Corpus-4oGuideline-All

Id Subject Object Predicate Lexical cue
T1 96-108 SpecificDisease denotes C5-deficient
T2 157-220 SpecificDisease denotes hereditary deficiency of the fifth component of complement (C5)
T3 317-335 SpecificDisease denotes C5-deficient (C5D)
T4 385-400 SpecificDisease denotes C5D homozygotes
T5 423-460 Modifier denotes inactive systemic lupus erythematosus
T6 988-1001 SpecificDisease denotes C5 deficiency
T7 1049-1058 SpecificDisease denotes C5D serum
T8 1204-1213 SpecificDisease denotes C5D serum
T9 1400-1435 SpecificDisease denotes paroxysmal nocturnal hemoglobinuria

NCBI-Disease-Corpus-Simple-All

Id Subject Object Predicate Lexical cue
T1 157-220 SpecificDisease denotes hereditary deficiency of the fifth component of complement (C5)
T2 432-460 SpecificDisease denotes systemic lupus erythematosus
T3 712-738 Modifier denotes Escherichia coli endotoxin
T4 988-1001 SpecificDisease denotes C5 deficiency
T5 1071-1111 Modifier denotes Saccharomyces cerevisiae (baker's yeast)
T6 1115-1131 Modifier denotes Candida albicans
T7 1288-1309 Modifier denotes Staphylococcus aureus
T8 1400-1435 SpecificDisease denotes paroxysmal nocturnal hemoglobinuria
T9 1565-1581 Modifier denotes Salmonella typhi
T10 1657-1665 Modifier denotes S. typhi