> top > docs > PubMed:7744799 > annotations

PubMed:7744799 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products.
T2 106-320 Sentence denotes Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent molecular lesion recognized in T-cell acute lymphoblastic leukemia.
T3 321-525 Sentence denotes The protein products of this gene contain the basic-helix-loop-helix motif characteristic of a large family of transcription factors that bind to the canonical DNA sequence CANNTG as protein heterodimers.
T4 526-699 Sentence denotes TAL1 expression by erythroid cells in vivo and in chemical-induced erythroleukemia cell lines in vivo suggested the gene might regulate aspects of erythroid differentiation.
T5 700-1026 Sentence denotes Since the terminal events of erythropoiesis are controlled by the glycoprotein hormone erythropoietin (Epo), we investigated whether the expression or activity of the TAL1 gene and its protein products were affected by Epo in splenic erythroblasts from mice infected with an anemia-inducing strain of Friend virus (FVA cells).
T6 1027-1157 Sentence denotes Epo elicited a rapid, dose-related increase in TAL1 mRNA by increasing transcription of the gene and stabilizing one of its mRNAs.
T7 1158-1309 Sentence denotes An Epo-inducible TAL1 DNA binding activity was identified in FVA cell nuclear extracts that subsequently decayed despite accumulating mRNA and protein.
T8 1310-1427 Sentence denotes Induction of DNA binding activity was associated temporally with Epo-induced phosphorylation of nuclear TAL1 protein.
T9 1428-1737 Sentence denotes These results indicate that Epo acts at both transcriptional and posttranscriptional levels on the TAL1 locus in Friend virus-induced erythroblasts and establish a link between Epo signaling mechanisms and a member of a family of transcription factors involved in the differentiation of diverse cell lineages.
T1 0-105 Sentence denotes Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products.
T2 106-320 Sentence denotes Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent molecular lesion recognized in T-cell acute lymphoblastic leukemia.
T3 321-525 Sentence denotes The protein products of this gene contain the basic-helix-loop-helix motif characteristic of a large family of transcription factors that bind to the canonical DNA sequence CANNTG as protein heterodimers.
T4 526-699 Sentence denotes TAL1 expression by erythroid cells in vivo and in chemical-induced erythroleukemia cell lines in vivo suggested the gene might regulate aspects of erythroid differentiation.
T5 700-1026 Sentence denotes Since the terminal events of erythropoiesis are controlled by the glycoprotein hormone erythropoietin (Epo), we investigated whether the expression or activity of the TAL1 gene and its protein products were affected by Epo in splenic erythroblasts from mice infected with an anemia-inducing strain of Friend virus (FVA cells).
T6 1027-1157 Sentence denotes Epo elicited a rapid, dose-related increase in TAL1 mRNA by increasing transcription of the gene and stabilizing one of its mRNAs.
T7 1158-1309 Sentence denotes An Epo-inducible TAL1 DNA binding activity was identified in FVA cell nuclear extracts that subsequently decayed despite accumulating mRNA and protein.
T8 1310-1427 Sentence denotes Induction of DNA binding activity was associated temporally with Epo-induced phosphorylation of nuclear TAL1 protein.
T9 1428-1737 Sentence denotes These results indicate that Epo acts at both transcriptional and posttranscriptional levels on the TAL1 locus in Friend virus-induced erythroblasts and establish a link between Epo signaling mechanisms and a member of a family of transcription factors involved in the differentiation of diverse cell lineages.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 526-530 gene:6886 denotes TAL1
T1 593-608 disease:C0023440 denotes erythroleukemia
R1 T0 T1 associated_with TAL1,erythroleukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-14 protein denotes Erythropoietin
T2 47-60 DNA denotes TAL1/SCL gene
T3 88-104 protein denotes protein products
T4 124-142 DNA denotes TAL1 (or SCL) gene
T5 325-341 protein denotes protein products
T6 367-395 protein denotes basic-helix-loop-helix motif
T7 432-453 protein denotes transcription factors
T8 471-500 DNA denotes canonical DNA sequence CANNTG
T9 504-524 protein denotes protein heterodimers
T10 526-530 protein denotes TAL1
T11 545-560 cell_type denotes erythroid cells
T12 576-619 cell_line denotes chemical-induced erythroleukemia cell lines
T13 766-801 protein denotes glycoprotein hormone erythropoietin
T14 803-806 protein denotes Epo
T15 867-876 DNA denotes TAL1 gene
T16 885-901 protein denotes protein products
T17 919-922 protein denotes Epo
T18 926-947 cell_type denotes splenic erythroblasts
T19 1027-1030 protein denotes Epo
T20 1074-1083 RNA denotes TAL1 mRNA
T21 1151-1156 RNA denotes mRNAs
T22 1161-1164 protein denotes Epo
T23 1175-1179 protein denotes TAL1
T24 1292-1296 RNA denotes mRNA
T25 1375-1378 protein denotes Epo
T26 1406-1426 protein denotes nuclear TAL1 protein
T27 1456-1459 protein denotes Epo
T28 1527-1531 protein denotes TAL1
T29 1541-1575 cell_line denotes Friend virus-induced erythroblasts
T30 1605-1608 protein denotes Epo
T31 1658-1679 protein denotes transcription factors
T32 1715-1736 cell_type denotes diverse cell lineages

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7744799-1#18#22#gene6886 124-128 gene6886 denotes TAL1
7744799-1#178#213#diseaseC1961099 284-319 diseaseC1961099 denotes T-cell acute lymphoblastic leukemia
7744799-3#0#4#gene6886 526-530 gene6886 denotes TAL1
7744799-3#67#82#diseaseC0023440 593-608 diseaseC0023440 denotes erythroleukemia
7744799-4#87#101#gene2056 787-801 gene2056 denotes erythropoietin
7744799-4#103#106#gene2056 803-806 gene2056 denotes Epo
7744799-4#167#171#gene6886 867-871 gene6886 denotes TAL1
7744799-4#219#222#gene2056 919-922 gene2056 denotes Epo
7744799-4#275#281#diseaseC0002871 975-981 diseaseC0002871 denotes anemia
18#22#gene6886178#213#diseaseC1961099 7744799-1#18#22#gene6886 7744799-1#178#213#diseaseC1961099 associated_with TAL1,T-cell acute lymphoblastic leukemia
0#4#gene688667#82#diseaseC0023440 7744799-3#0#4#gene6886 7744799-3#67#82#diseaseC0023440 associated_with TAL1,erythroleukemia
87#101#gene2056275#281#diseaseC0002871 7744799-4#87#101#gene2056 7744799-4#275#281#diseaseC0002871 associated_with erythropoietin,anemia
103#106#gene2056275#281#diseaseC0002871 7744799-4#103#106#gene2056 7744799-4#275#281#diseaseC0002871 associated_with Epo,anemia
167#171#gene6886275#281#diseaseC0002871 7744799-4#167#171#gene6886 7744799-4#275#281#diseaseC0002871 associated_with TAL1,anemia
219#222#gene2056275#281#diseaseC0002871 7744799-4#219#222#gene2056 7744799-4#275#281#diseaseC0002871 associated_with Epo,anemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-105 Sentence denotes Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products.
S2 106-320 Sentence denotes Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent molecular lesion recognized in T-cell acute lymphoblastic leukemia.
S3 321-525 Sentence denotes The protein products of this gene contain the basic-helix-loop-helix motif characteristic of a large family of transcription factors that bind to the canonical DNA sequence CANNTG as protein heterodimers.
S4 526-699 Sentence denotes TAL1 expression by erythroid cells in vivo and in chemical-induced erythroleukemia cell lines in vivo suggested the gene might regulate aspects of erythroid differentiation.
S5 700-1026 Sentence denotes Since the terminal events of erythropoiesis are controlled by the glycoprotein hormone erythropoietin (Epo), we investigated whether the expression or activity of the TAL1 gene and its protein products were affected by Epo in splenic erythroblasts from mice infected with an anemia-inducing strain of Friend virus (FVA cells).
S6 1027-1157 Sentence denotes Epo elicited a rapid, dose-related increase in TAL1 mRNA by increasing transcription of the gene and stabilizing one of its mRNAs.
S7 1158-1309 Sentence denotes An Epo-inducible TAL1 DNA binding activity was identified in FVA cell nuclear extracts that subsequently decayed despite accumulating mRNA and protein.
S8 1310-1427 Sentence denotes Induction of DNA binding activity was associated temporally with Epo-induced phosphorylation of nuclear TAL1 protein.
S9 1428-1737 Sentence denotes These results indicate that Epo acts at both transcriptional and posttranscriptional levels on the TAL1 locus in Friend virus-induced erythroblasts and establish a link between Epo signaling mechanisms and a member of a family of transcription factors involved in the differentiation of diverse cell lineages.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 43-60 NP denotes the TAL1/SCL gene
C2 84-87 NP denotes its
C3 120-142 NP denotes the TAL1 (or SCL) gene
C4 174-177 NP denotes its
C5 345-354 NP denotes this gene
C6 432-453 NP denotes transcription factors
C7 454-458 NP denotes that
C8 638-646 NP denotes the gene
C11 762-807 NP denotes the glycoprotein hormone erythropoietin (Epo)
C9 863-876 NP denotes the TAL1 gene
C10 881-884 NP denotes its
C12 919-922 NP denotes Epo
C13 1027-1030 NP denotes Epo
C14 1115-1123 NP denotes the gene
C17 1140-1143 NP denotes one
C16 1147-1150 NP denotes its
C15 1147-1156 NP denotes its mRNAs
C18 1161-1165 NP denotes Epo-
C19 1219-1244 NP denotes FVA cell nuclear extracts
C20 1245-1249 NP denotes that
C21 1375-1379 NP denotes Epo-
C22 1456-1459 NP denotes Epo
R1 C2 C1 coref-ident its,the TAL1/SCL gene
R2 C3 C1 coref-ident the TAL1 (or SCL) gene,the TAL1/SCL gene
R3 C4 C3 coref-pron its,the TAL1 (or SCL) gene
R4 C5 C3 coref-ident this gene,the TAL1 (or SCL) gene
R5 C7 C6 coref-relat that,transcription factors
R6 C8 C5 coref-ident the gene,this gene
R7 C9 C8 coref-ident the TAL1 gene,the gene
R8 C10 C9 coref-pron its,the TAL1 gene
R9 C12 C11 coref-ident Epo,the glycoprotein hormone erythropoietin (Epo)
R10 C13 C12 coref-ident Epo,Epo
R11 C14 C9 coref-ident the gene,the TAL1 gene
R12 C17 C15 coref-part-whole one,its mRNAs
R13 C16 C14 coref-pron its,the gene
R14 C18 C13 coref-ident Epo-,Epo
R15 C20 C19 coref-relat that,FVA cell nuclear extracts
R16 C21 C18 coref-ident Epo-,Epo-
R17 C22 C21 coref-ident Epo,Epo-

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 protein_molecule denotes Erythropoietin
T2 47-60 DNA_domain_or_region denotes TAL1/SCL gene
T3 65-80 other_name denotes phosphorylation
T4 88-104 protein_domain_or_region denotes protein products
T5 124-142 DNA_domain_or_region denotes TAL1 (or SCL) gene
T6 195-230 other_name denotes recurrent chromosomal translocation
T7 284-319 other_name denotes T-cell acute lymphoblastic leukemia
T8 325-341 protein_family_or_group denotes protein products
T9 367-395 protein_family_or_group denotes basic-helix-loop-helix motif
T10 432-453 protein_family_or_group denotes transcription factors
T11 471-500 DNA_domain_or_region denotes canonical DNA sequence CANNTG
T12 504-524 protein_family_or_group denotes protein heterodimers
T13 526-530 protein_molecule denotes TAL1
T14 545-560 cell_type denotes erythroid cells
T15 576-619 cell_line denotes chemical-induced erythroleukemia cell lines
T16 673-698 other_name denotes erythroid differentiation
T17 729-743 other_name denotes erythropoiesis
T18 766-801 protein_molecule denotes glycoprotein hormone erythropoietin
T19 803-806 protein_molecule denotes Epo
T20 867-871 protein_molecule denotes TAL1
T21 885-901 protein_family_or_group denotes protein products
T22 919-922 protein_molecule denotes Epo
T23 926-947 cell_type denotes splenic erythroblasts
T24 953-957 multi_cell denotes mice
T25 1027-1030 protein_molecule denotes Epo
T26 1074-1078 protein_molecule denotes TAL1
T27 1098-1111 other_name denotes transcription
T28 1151-1156 RNA_family_or_group denotes mRNAs
T29 1161-1164 protein_molecule denotes Epo
T30 1175-1179 protein_molecule denotes TAL1
T31 1219-1244 cell_component denotes FVA cell nuclear extracts
T32 1292-1296 RNA_family_or_group denotes mRNA
T33 1323-1343 other_name denotes DNA binding activity
T34 1375-1378 protein_molecule denotes Epo
T35 1387-1402 other_name denotes phosphorylation
T36 1406-1413 protein_molecule denotes nuclear
T37 1414-1418 protein_molecule denotes TAL1
T38 1456-1459 protein_molecule denotes Epo
T39 1527-1531 protein_molecule denotes TAL1
T40 1541-1553 virus denotes Friend virus
T41 1605-1608 protein_molecule denotes Epo
T42 1658-1679 protein_family_or_group denotes transcription factors
T43 1715-1736 cell_type denotes diverse cell lineages

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 284-319 Disease denotes T-cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0003540|http://purl.obolibrary.org/obo/MONDO_0004963
T3 593-608 Disease denotes erythroleukemia http://purl.obolibrary.org/obo/MONDO_0017858
T4 975-981 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 953-957 OrganismTaxon denotes mice 10088
T2 975-981 OrganismTaxon denotes anemia 12939

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 284-290 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 373-378 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T3 384-389 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T4 934-947 Body_part denotes erythroblasts http://purl.obolibrary.org/obo/CL_0000765
T5 1562-1575 Body_part denotes erythroblasts http://purl.obolibrary.org/obo/CL_0000765

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 284-319 Phenotype denotes T-cell acute lymphoblastic leukemia HP:0006727
T2 975-981 Phenotype denotes anemia HP:0001903

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 284-290 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 297-310 Cell denotes lymphoblastic http://purl.obolibrary.org/obo/CL:0017005
T3 934-947 Cell denotes erythroblasts http://purl.obolibrary.org/obo/CL:0000765
T4 1562-1575 Cell denotes erythroblasts http://purl.obolibrary.org/obo/CL:0000765