PubMed:7744780 / 764-1051 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T5","span":{"begin":0,"end":287},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":287},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"For the renin reaction on a full-length substrate, this substitution leads to a 10-fold decrease in Km (from 1.1 to 0.09 microM) and a 5-fold decrease in kcat (from 1.0 to 0.22 s-1); as a result, catalytic efficiency (kcat/Km) is increased by a factor of 2 (1.1 versus 2.4 microM-1 s-1)."}