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PubMed:7744780 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-119 Sentence denotes A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system.
TextSentencer_T2 120-344 Sentence denotes Angiotensinogen exhibits genetic linkage to and association with essential hypertension and preeclampsia, a common hypertensive disorder of pregnancy; however, the polymorphisms detected thus far provide no functional clues.
TextSentencer_T3 345-533 Sentence denotes In a preeclamptic patient, we have identified a mutation leading to the replacement of leucine by phenylalanine at position 10 of mature angiotensinogen (L10F), the site of renin cleavage.
TextSentencer_T4 534-763 Sentence denotes Kinetic analyses of the enzymes of the renin-angiotensin system, using either model peptides or full-length substrates, show that this mutation significantly alters the reactions with both renin and angiotensin-converting enzyme.
TextSentencer_T5 764-1051 Sentence denotes For the renin reaction on a full-length substrate, this substitution leads to a 10-fold decrease in Km (from 1.1 to 0.09 microM) and a 5-fold decrease in kcat (from 1.0 to 0.22 s-1); as a result, catalytic efficiency (kcat/Km) is increased by a factor of 2 (1.1 versus 2.4 microM-1 s-1).
TextSentencer_T6 1052-1305 Sentence denotes In the reaction of angiotensin-converting enzyme on angiotensin decapeptides, the substitution has no effect on Km (38.0 versus 30.0 microM), but increases kcat and catalytic efficiency > 2-fold (kcat = 15.0 versus 37.0 s-1; kcat/Km = 0.41 versus 1.23).
TextSentencer_T7 1306-1512 Sentence denotes The renin-angiotensin system, challenged by the profound physiological adaptations of pregnancy, is perturbed in preeclampsia; consequently, the L10F mutation may promote this condition in carrier subjects.
T1 0-119 Sentence denotes A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system.
T2 120-344 Sentence denotes Angiotensinogen exhibits genetic linkage to and association with essential hypertension and preeclampsia, a common hypertensive disorder of pregnancy; however, the polymorphisms detected thus far provide no functional clues.
T3 345-533 Sentence denotes In a preeclamptic patient, we have identified a mutation leading to the replacement of leucine by phenylalanine at position 10 of mature angiotensinogen (L10F), the site of renin cleavage.
T4 534-763 Sentence denotes Kinetic analyses of the enzymes of the renin-angiotensin system, using either model peptides or full-length substrates, show that this mutation significantly alters the reactions with both renin and angiotensin-converting enzyme.
T5 764-1051 Sentence denotes For the renin reaction on a full-length substrate, this substitution leads to a 10-fold decrease in Km (from 1.1 to 0.09 microM) and a 5-fold decrease in kcat (from 1.0 to 0.22 s-1); as a result, catalytic efficiency (kcat/Km) is increased by a factor of 2 (1.1 versus 2.4 microM-1 s-1).
T6 1052-1305 Sentence denotes In the reaction of angiotensin-converting enzyme on angiotensin decapeptides, the substitution has no effect on Km (38.0 versus 30.0 microM), but increases kcat and catalytic efficiency > 2-fold (kcat = 15.0 versus 37.0 s-1; kcat/Km = 0.41 versus 1.23).
T7 1306-1512 Sentence denotes The renin-angiotensin system, challenged by the profound physiological adaptations of pregnancy, is perturbed in preeclampsia; consequently, the L10F mutation may promote this condition in carrier subjects.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 120-135 gene:183 denotes Angiotensinogen
T1 185-207 disease:C0085580 denotes essential hypertension
T2 120-135 gene:183 denotes Angiotensinogen
T3 235-256 disease:C0020538 denotes hypertensive disorder
R1 T0 T1 associated_with Angiotensinogen,essential hypertension
R2 T2 T3 associated_with Angiotensinogen,hypertensive disorder

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7744780-1#0#15#gene183 120-135 gene183 denotes Angiotensinogen
7744780-1#65#87#diseaseC0085580 185-207 diseaseC0085580 denotes essential hypertension
7744780-1#115#136#diseaseC0020538 235-256 diseaseC0020538 denotes hypertensive disorder
0#15#gene18365#87#diseaseC0085580 7744780-1#0#15#gene183 7744780-1#65#87#diseaseC0085580 associated_with Angiotensinogen,essential hypertension
0#15#gene183115#136#diseaseC0020538 7744780-1#0#15#gene183 7744780-1#115#136#diseaseC0020538 associated_with Angiotensinogen,hypertensive disorder

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 48-60 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 212-224 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 235-269 ORPHA:275555 denotes hypertensive disorder of pregnancy
PD-Preeclampsia-B_T4 350-370 ORPHA:275555 denotes preeclamptic patient
PD-Preeclampsia-B_T5 1419-1431 ORPHA:275555 denotes preeclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 48-60 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 212-224 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 235-269 ORPHA:275555 denotes hypertensive disorder of pregnancy
PD-Preeclampsia-B_T4 350-370 ORPHA:275555 denotes preeclamptic patient
PD-Preeclampsia-B_T5 1419-1431 ORPHA:275555 denotes preeclampsia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 94-118 http://purl.obolibrary.org/obo/UBERON_0018229 denotes renin-angiotensin system
PD-UBERON-AE-B_T2 573-597 http://purl.obolibrary.org/obo/UBERON_0018229 denotes renin-angiotensin system
PD-UBERON-AE-B_T3 1310-1334 http://purl.obolibrary.org/obo/UBERON_0018229 denotes renin-angiotensin system

preeclampsia_genes

Id Subject Object Predicate Lexical cue
PD-PreeclampsiaGenes-B_T1 14-29 HGNC:AGT denotes angiotensinogen
PD-PreeclampsiaGenes-B_T2 120-135 HGNC:AGT denotes Angiotensinogen
PD-PreeclampsiaGenes-B_T3 482-497 HGNC:AGT denotes angiotensinogen

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 48-60 HP:0100602 denotes preeclampsia
AB1 195-207 HP:0000822 denotes hypertension
AB2 212-224 HP:0100602 denotes preeclampsia
AB3 1419-1431 HP:0100602 denotes preeclampsia

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 48-60 ORDO:275555 denotes preeclampsia
AB1 212-224 ORDO:275555 denotes preeclampsia
AB2 1419-1431 ORDO:275555 denotes preeclampsia

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 94-118 http://purl.obolibrary.org/obo/UBERON_0018229 denotes renin-angiotensin system
PD-UBERON-AE-B_T2 573-597 http://purl.obolibrary.org/obo/UBERON_0018229 denotes renin-angiotensin system
PD-UBERON-AE-B_T3 1310-1334 http://purl.obolibrary.org/obo/UBERON_0018229 denotes renin-angiotensin system

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 195-207 Phenotype denotes hypertension HP:0000822

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 48-60 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T2 185-207 Disease denotes essential hypertension http://purl.obolibrary.org/obo/MONDO_0001134
T3 212-224 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T4 235-256 Disease denotes hypertensive disorder http://purl.obolibrary.org/obo/MONDO_0005044
T5 1419-1431 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 35-42 OrganismTaxon denotes patient 9606
T2 363-370 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 94-118 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T2 573-597 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T3 1310-1334 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229