PubMed:7744247 JSONTXT

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein"},{"id":"T2","span":{"begin":22,"end":39},"obj":"protein"},{"id":"T3","span":{"begin":105,"end":108},"obj":"protein"},{"id":"T4","span":{"begin":113,"end":117},"obj":"protein"},{"id":"T5","span":{"begin":364,"end":381},"obj":"protein"},{"id":"T6","span":{"begin":398,"end":402},"obj":"protein"},{"id":"T7","span":{"begin":472,"end":489},"obj":"protein"},{"id":"T8","span":{"begin":521,"end":525},"obj":"protein"},{"id":"T9","span":{"begin":596,"end":599},"obj":"protein"},{"id":"T10","span":{"begin":600,"end":604},"obj":"protein"},{"id":"T11","span":{"begin":643,"end":648},"obj":"protein"}],"text":"Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.\nThe Ras and Raf1 proto-oncogenes transduce extracellular signals that promote cell growth. Cdc25 phosphatases activate the cell division cycle by dephosphorylation of critical threonine and tyrosine residues within the cyclin-dependent kinases. We show here that Cdc25 phosphatase associates with raf1 in somatic mammalian cells and in meiotic frog oocytes. Furthermore, Cdc25 phosphatase can be activated in vitro in a Raf1-dependent manner. We suggest that activation of the cell cycle by the Ras/Raf1 pathways might be mediated in part by Cdc25."}