> top > docs > PubMed:7738013 > annotations

PubMed:7738013 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-51 Sentence denotes Mouse interleukin-2 receptor alpha gene expression.
T2 52-139 Sentence denotes Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.
T3 140-293 Sentence denotes We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors.
T4 294-449 Sentence denotes Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma (PC60).
T5 450-545 Sentence denotes The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.
T6 546-684 Sentence denotes IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation.
T7 685-848 Sentence denotes It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts.
T8 849-1076 Sentence denotes Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene.
T9 1077-1213 Sentence denotes IL-2 responsiveness, on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site.
T10 1214-1395 Sentence denotes This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.
T11 1396-1469 Sentence denotes IL-2 responsiveness requires three distinct elements within the enhancer.
T12 1470-1529 Sentence denotes Two of these are potential binding sites for STAT proteins.
T1 0-51 Sentence denotes Mouse interleukin-2 receptor alpha gene expression.
T2 52-139 Sentence denotes Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.
T3 140-293 Sentence denotes We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors.
T4 294-449 Sentence denotes Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma (PC60).
T5 450-545 Sentence denotes The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.
T6 546-684 Sentence denotes IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation.
T7 685-848 Sentence denotes It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts.
T8 849-1076 Sentence denotes Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene.
T9 1077-1213 Sentence denotes IL-2 responsiveness, on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site.
T10 1214-1395 Sentence denotes This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.
T11 1396-1469 Sentence denotes IL-2 responsiveness requires three distinct elements within the enhancer.
T12 1470-1529 Sentence denotes Two of these are potential binding sites for STAT proteins.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 927-935 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T2 1111-1115 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-39 DNA denotes Mouse interleukin-2 receptor alpha gene
T2 52-65 protein denotes Interleukin-1
T3 70-83 protein denotes interleukin-2
T4 119-138 DNA denotes cis-acting elements
T5 159-172 protein denotes interleukin-1
T6 174-178 protein denotes IL-1
T7 184-188 protein denotes IL-2
T8 197-235 DNA denotes IL-2 receptor alpha (IL-2R alpha) gene
T9 253-292 cell_line denotes CD4-CD8- murine T lymphocyte precursors
T10 310-329 DNA denotes cis-acting elements
T11 377-399 DNA denotes mouse IL-2R alpha gene
T12 408-441 cell_line denotes thymic lymphoma-derived hybridoma
T13 443-447 cell_line denotes PC60
T14 486-502 DNA denotes IL-2R alpha gene
T15 521-525 protein denotes IL-1
T16 528-532 protein denotes IL-2
T17 546-550 protein denotes IL-1
T18 612-628 RNA denotes IL-2R alpha mRNA
T19 662-672 protein denotes NF-kappa B
T20 716-720 protein denotes IL-2
T21 780-784 protein denotes IL-2
T22 824-847 RNA denotes IL-2R alpha transcripts
T23 918-942 DNA denotes promoter-proximal region
T24 950-966 DNA denotes IL-2R alpha gene
T25 981-985 protein denotes IL-1
T26 1022-1037 DNA denotes NF-kappa B site
T27 1055-1075 DNA denotes human and mouse gene
T28 1077-1081 protein denotes IL-2
T29 1130-1151 DNA denotes 78-nucleotide segment
T30 1182-1212 DNA denotes major transcription start site
T31 1243-1266 DNA denotes IL-2-inducible enhancer
T32 1305-1312 protein denotes DNase I
T33 1338-1345 cell_type denotes T cells
T34 1355-1366 protein denotes IL-2R alpha
T35 1396-1400 protein denotes IL-2
T36 1440-1448 DNA denotes elements
T37 1460-1468 DNA denotes enhancer
T38 1515-1528 protein denotes STAT proteins

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 52-65 NP denotes Interleukin-1
C2 70-83 NP denotes interleukin-2
C3 159-179 NP denotes interleukin-1 (IL-1)
C4 184-188 NP denotes IL-2
C5 306-329 NP denotes the cis-acting elements
C6 330-334 NP denotes that
C7 373-399 NP denotes the mouse IL-2R alpha gene
C8 482-502 NP denotes the IL-2R alpha gene
C9 521-525 NP denotes IL-1
C10 528-532 NP denotes IL-2
C11 546-550 NP denotes IL-1
C12 612-628 NP denotes IL-2R alpha mRNA
C13 629-633 NP denotes that
C14 685-687 NP denotes It
C15 716-720 NP denotes IL-2
C16 753-769 NP denotes the second phase
C17 774-779 NP denotes which
C18 780-784 NP denotes IL-2
C19 946-966 NP denotes the IL-2R alpha gene
C25 1077-1096 NP denotes IL-2 responsiveness
C20 1243-1248 NP denotes IL-2-
C27 1240-1266 NP denotes an IL-2-inducible enhancer
C21 1283-1291 NP denotes a region
C22 1292-1296 NP denotes that
C23 1331-1345 NP denotes normal T cells
C24 1349-1354 NP denotes which
C26 1396-1415 NP denotes IL-2 responsiveness
C28 1456-1468 NP denotes the enhancer
C29 1425-1468 NP denotes three distinct elements within the enhancer
C30 1477-1482 NP denotes these
C31 1470-1482 NP denotes Two of these
R1 C3 C1 coref-ident interleukin-1 (IL-1),Interleukin-1
R2 C4 C2 coref-ident IL-2,interleukin-2
R3 C6 C5 coref-relat that,the cis-acting elements
R4 C8 C7 coref-ident the IL-2R alpha gene,the mouse IL-2R alpha gene
R5 C9 C3 coref-ident IL-1,interleukin-1 (IL-1)
R6 C10 C4 coref-ident IL-2,IL-2
R7 C11 C9 coref-ident IL-1,IL-1
R8 C13 C12 coref-relat that,IL-2R alpha mRNA
R9 C14 C11 coref-pron It,IL-1
R10 C15 C10 coref-ident IL-2,IL-2
R11 C17 C16 coref-relat which,the second phase
R12 C18 C15 coref-ident IL-2,IL-2
R13 C19 C8 coref-ident the IL-2R alpha gene,the IL-2R alpha gene
R14 C20 C18 coref-ident IL-2-,IL-2
R15 C22 C21 coref-relat that,a region
R16 C24 C23 coref-relat which,normal T cells
R17 C26 C25 coref-ident IL-2 responsiveness,IL-2 responsiveness
R18 C28 C27 coref-ident the enhancer,an IL-2-inducible enhancer
R19 C30 C29 coref-pron these,three distinct elements within the enhancer
R20 C31 C29 coref-part-whole Two of these,three distinct elements within the enhancer

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-51 Sentence denotes Mouse interleukin-2 receptor alpha gene expression.
S2 52-139 Sentence denotes Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.
S3 140-293 Sentence denotes We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors.
S4 294-449 Sentence denotes Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma (PC60).
S5 450-545 Sentence denotes The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.
S6 546-684 Sentence denotes IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation.
S7 685-848 Sentence denotes It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts.
S8 849-1076 Sentence denotes Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene.
S9 1077-1213 Sentence denotes IL-2 responsiveness, on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site.
S10 1214-1395 Sentence denotes This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.
S11 1396-1469 Sentence denotes IL-2 responsiveness requires three distinct elements within the enhancer.
S12 1470-1529 Sentence denotes Two of these are potential binding sites for STAT proteins.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 DNA_domain_or_region denotes Mouse
T2 6-19 protein_molecule denotes interleukin-2
T3 52-65 protein_molecule denotes Interleukin-1
T4 70-83 protein_molecule denotes interleukin-2
T5 119-138 DNA_family_or_group denotes cis-acting elements
T6 159-172 protein_molecule denotes interleukin-1
T7 174-178 protein_molecule denotes IL-1
T8 184-188 protein_molecule denotes IL-2
T9 197-216 protein_molecule denotes IL-2 receptor alpha
T10 218-229 protein_molecule denotes IL-2R alpha
T11 253-292 cell_line denotes CD4-CD8- murine T lymphocyte precursors
T12 310-329 DNA_family_or_group denotes cis-acting elements
T13 377-394 protein_molecule denotes mouse IL-2R alpha
T14 408-441 cell_line denotes thymic lymphoma-derived hybridoma
T15 443-447 cell_line denotes PC60
T16 486-502 DNA_domain_or_region denotes IL-2R alpha gene
T17 521-525 protein_molecule denotes IL-1
T18 528-532 protein_molecule denotes IL-2
T19 546-550 protein_molecule denotes IL-1
T20 568-608 other_name denotes protein synthesis-independent appearance
T21 612-623 protein_molecule denotes IL-2R alpha
T22 662-672 protein_molecule denotes NF-kappa B
T23 716-720 protein_molecule denotes IL-2
T24 780-784 protein_molecule denotes IL-2
T25 824-835 protein_molecule denotes IL-2R alpha
T26 849-883 other_name denotes Transient transfection experiments
T27 918-942 DNA_domain_or_region denotes promoter-proximal region
T28 950-961 protein_molecule denotes IL-2R alpha
T29 981-985 protein_molecule denotes IL-1
T30 1022-1032 protein_molecule denotes NF-kappa B
T31 1077-1081 protein_molecule denotes IL-2
T32 1130-1151 DNA_domain_or_region denotes 78-nucleotide segment
T33 1182-1212 DNA_domain_or_region denotes major transcription start site
T34 1243-1266 DNA_domain_or_region denotes IL-2-inducible enhancer
T35 1305-1312 protein_molecule denotes DNase I
T36 1338-1345 cell_type denotes T cells
T37 1355-1366 protein_molecule denotes IL-2R alpha
T38 1396-1400 protein_molecule denotes IL-2
T39 1440-1448 DNA_domain_or_region denotes elements
T40 1460-1468 DNA_domain_or_region denotes enhancer
T41 1515-1528 protein_family_or_group denotes STAT proteins

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 927-935 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491
T2 1111-1115 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 415-423 Phenotype denotes lymphoma HP:0002665
T2 1313-1327 Phenotype denotes hypersensitive HP:0041092

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 408-423 Disease denotes thymic lymphoma http://purl.obolibrary.org/obo/MONDO_0000951
T2 1313-1327 Disease denotes hypersensitive http://purl.obolibrary.org/obo/MONDO_0000605

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Mouse 10088|10090
T3 377-382 OrganismTaxon denotes mouse 10088|10090
T5 1055-1060 OrganismTaxon denotes human 9606
T6 1065-1070 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 269-281 Body_part denotes T lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T2 1111-1115 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T3 1144-1151 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914
T4 1219-1226 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 269-281 Cell denotes T lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T2 271-281 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T3 1338-1345 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084