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PubMed:7727787 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 116-127 gene:3050 denotes zeta-globin
T1 272-287 disease:C0023440 denotes erythroleukemia
T2 167-178 gene:3050 denotes zeta-globin
T3 272-287 disease:C0023440 denotes erythroleukemia
R1 T0 T1 associated_with zeta-globin,erythroleukemia
R2 T2 T3 associated_with zeta-globin,erythroleukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 26-53 DNA denotes positive regulatory element
T2 72-94 DNA denotes human zeta-globin gene
T3 116-136 DNA denotes zeta-globin promoter
T4 167-207 DNA denotes zeta-globin promoter deletion constructs
T5 217-227 protein denotes luciferase
T6 242-293 cell_line denotes transiently transfected human erythroleukemia cells
T7 299-308 DNA denotes promoters
T8 327-336 DNA denotes enhancers
T9 346-355 DNA denotes enhancers
T10 373-405 DNA denotes beta-globin locus control region
T11 414-441 DNA denotes alpha-globin HS-40 enhancer
T12 465-475 cell_line denotes K562 cells
T13 491-502 protein denotes zeta-globin
T14 558-598 DNA denotes -557 and -417 zeta-luciferase constructs
T15 607-634 DNA denotes alpha-luciferase constructs
T16 643-652 DNA denotes enhancers
T17 660-688 DNA denotes alpha-globin locus enhancers
T18 742-753 cell_line denotes OCIM1 cells
T19 776-787 protein denotes zeta-globin
T20 793-814 DNA denotes zeta-globin promoters
T21 849-871 DNA denotes alpha-globin promoters
T22 878-908 DNA denotes sequences from -417 to -207 5'
T23 916-941 RNA denotes zeta-globin mRNA cap site
T24 973-993 DNA denotes zeta-globin promoter
T25 1015-1025 cell_line denotes K562 cells
T26 1063-1089 DNA denotes zeta-luciferase constructs
T27 1202-1213 DNA denotes GATA-1 site
T28 1276-1286 DNA denotes CCACC site
T29 1367-1383 DNA denotes -230 GATA-1 site
T30 1418-1424 protein denotes GATA-1
T31 1474-1497 DNA denotes positive-acting element
T32 1515-1534 DNA denotes -417 and -207 bp 5'
T33 1542-1567 DNA denotes zeta-globin mRNA cap site
T34 1618-1628 cell_line denotes K562 cells
T35 1652-1658 protein denotes GATA-1
T36 1663-1689 protein denotes additional unknown factors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7727787-1#20#31#gene3050 116-127 gene3050 denotes zeta-globin
7727787-1#71#82#gene3050 167-178 gene3050 denotes zeta-globin
7727787-1#176#191#diseaseC0023440 272-287 diseaseC0023440 denotes erythroleukemia
20#31#gene3050176#191#diseaseC0023440 7727787-1#20#31#gene3050 7727787-1#176#191#diseaseC0023440 associated_with zeta-globin,erythroleukemia
71#82#gene3050176#191#diseaseC0023440 7727787-1#71#82#gene3050 7727787-1#176#191#diseaseC0023440 associated_with zeta-globin,erythroleukemia

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 68-94 NP denotes the human zeta-globin gene
C2 112-136 NP denotes the zeta-globin promoter
C3 155-207 NP denotes a series of zeta-globin promoter deletion constructs
C4 295-308 NP denotes The promoters
C5 465-475 NP denotes K562 cells
C6 477-482 NP denotes which
C7 491-502 NP denotes zeta-globin
C8 549-634 NP denotes from the -557 and -417 zeta-luciferase constructs and the alpha-luciferase constructs
C9 705-719 NP denotes the constructs
C10 742-753 NP denotes OCIM1 cells
C11 755-760 NP denotes which
C12 776-787 NP denotes zeta-globin
C13 789-814 NP denotes the zeta-globin promoters
C15 893-941 NP denotes -417 to -207 5' to the zeta-globin mRNA cap site
C14 878-941 NP denotes sequences from -417 to -207 5' to the zeta-globin mRNA cap site
C16 1015-1025 NP denotes K562 cells
C17 1042-1057 NP denotes these sequences
C18 1134-1147 NP denotes the sequences
C19 1200-1221 NP denotes a GATA-1 site at -230
C20 1363-1383 NP denotes the -230 GATA-1 site
C21 1418-1424 NP denotes GATA-1
C22 1515-1567 NP denotes -417 and -207 bp 5' to the zeta-globin mRNA cap site
C23 1618-1628 NP denotes K562 cells
C24 1652-1658 NP denotes GATA-1
R1 C4 C3 coref-ident The promoters,a series of zeta-globin promoter deletion constructs
R2 C6 C5 coref-relat which,K562 cells
R3 C7 C1 coref-ident zeta-globin,the human zeta-globin gene
R4 C9 C8 coref-ident the constructs,from the -557 and -417 zeta-luciferase constructs and the alpha-luciferase constructs
R5 C11 C10 coref-relat which,OCIM1 cells
R6 C12 C7 coref-ident zeta-globin,zeta-globin
R7 C13 C2 coref-ident the zeta-globin promoters,the zeta-globin promoter
R8 C16 C5 coref-ident K562 cells,K562 cells
R9 C17 C14 coref-ident these sequences,sequences from -417 to -207 5' to the zeta-globin mRNA cap site
R10 C18 C17 coref-ident the sequences,these sequences
R11 C20 C19 coref-ident the -230 GATA-1 site,a GATA-1 site at -230
R12 C22 C15 coref-ident -417 and -207 bp 5' to the zeta-globin mRNA cap site,-417 to -207 5' to the zeta-globin mRNA cap site
R13 C23 C16 coref-ident K562 cells,K562 cells
R14 C24 C21 coref-ident GATA-1,GATA-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-95 Sentence denotes Identification of a major positive regulatory element located 5' to the human zeta-globin gene.
S2 96-294 Sentence denotes The function of the zeta-globin promoter was studied using a series of zeta-globin promoter deletion constructs to drive luciferase expression in transiently transfected human erythroleukemia cells.
S3 295-442 Sentence denotes The promoters were used without enhancers, or with enhancers derived from the beta-globin locus control region and the alpha-globin HS-40 enhancer.
S4 443-699 Sentence denotes When transfected into K562 cells, which express zeta-globin, comparable amounts of activity were obtained from the -557 and -417 zeta-luciferase constructs and the alpha-luciferase constructs when no enhancers or the alpha-globin locus enhancers were used.
S5 700-872 Sentence denotes When the constructs were transfected into OCIM1 cells, which do not express zeta-globin, the zeta-globin promoters were at best 20% as active as the alpha-globin promoters.
S6 873-1026 Sentence denotes When sequences from -417 to -207 5' to the zeta-globin mRNA cap site were deleted, up to 95% of the zeta-globin promoter activity was lost in K562 cells.
S7 1027-1181 Sentence denotes Reinsertion of these sequences into zeta-luciferase constructs missing the -417 to -207 region showed that the sequences lack classical enhancer activity.
S8 1182-1255 Sentence denotes Point mutation of a GATA-1 site at -230 reduced promoter activity by 37%.
S9 1256-1309 Sentence denotes Point mutation of a CCACC site at -240 had no effect.
S10 1310-1425 Sentence denotes Electrophoretic mobility shift assays indicated that the -230 GATA-1 site has a relatively low affinity for GATA-1.
S11 1426-1629 Sentence denotes These experiments show the presence of a strong positive-acting element, located between -417 and -207 bp 5' to the zeta-globin mRNA cap site, is necessary for high-level promoter activity in K562 cells.
S12 1630-1711 Sentence denotes This element requires GATA-1 and additional unknown factors for maximal activity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 26-53 DNA_family_or_group denotes positive regulatory element
T2 72-94 DNA_domain_or_region denotes human zeta-globin gene
T3 116-136 DNA_domain_or_region denotes zeta-globin promoter
T4 167-187 DNA_domain_or_region denotes zeta-globin promoter
T5 217-227 protein_molecule denotes luciferase
T6 242-293 cell_line denotes transiently transfected human erythroleukemia cells
T7 299-308 DNA_family_or_group denotes promoters
T8 327-336 DNA_family_or_group denotes enhancers
T9 346-355 DNA_family_or_group denotes enhancers
T10 373-405 DNA_domain_or_region denotes beta-globin locus control region
T11 414-441 DNA_domain_or_region denotes alpha-globin HS-40 enhancer
T12 465-475 cell_line denotes K562 cells
T13 491-502 protein_family_or_group denotes zeta-globin
T14 558-577 DNA_molecule denotes -557 and -417 zeta-
T15 577-587 protein_molecule denotes luciferase
T16 607-613 DNA_molecule denotes alpha-
T17 613-623 protein_molecule denotes luciferase
T18 643-652 DNA_family_or_group denotes enhancers
T19 660-678 DNA_domain_or_region denotes alpha-globin locus
T20 679-688 DNA_family_or_group denotes enhancers
T21 742-753 cell_line denotes OCIM1 cells
T22 776-787 protein_family_or_group denotes zeta-globin
T23 793-804 protein_family_or_group denotes zeta-globin
T24 849-861 DNA_family_or_group denotes alpha-globin
T25 862-871 DNA_family_or_group denotes promoters
T26 878-908 DNA_domain_or_region denotes sequences from -417 to -207 5'
T27 916-932 RNA_molecule denotes zeta-globin mRNA
T28 973-984 protein_family_or_group denotes zeta-globin
T29 1015-1025 cell_line denotes K562 cells
T30 1063-1068 DNA_family_or_group denotes zeta-
T31 1068-1078 protein_molecule denotes luciferase
T32 1153-1180 other_name denotes classical enhancer activity
T33 1182-1196 other_name denotes Point mutation
T34 1202-1208 protein_molecule denotes GATA-1
T35 1230-1247 other_name denotes promoter activity
T36 1256-1270 other_name denotes Point mutation
T37 1276-1286 DNA_domain_or_region denotes CCACC site
T38 1310-1347 other_name denotes Electrophoretic mobility shift assays
T39 1367-1371 DNA_domain_or_region denotes -230
T40 1372-1378 protein_molecule denotes GATA-1
T41 1418-1424 protein_molecule denotes GATA-1
T42 1474-1497 DNA_domain_or_region denotes positive-acting element
T43 1515-1534 DNA_domain_or_region denotes -417 and -207 bp 5'
T44 1542-1553 protein_family_or_group denotes zeta-globin
T45 1586-1614 other_name denotes high-level promoter activity
T46 1618-1628 cell_line denotes K562 cells
T47 1652-1658 protein_molecule denotes GATA-1
T48 1663-1689 protein_family_or_group denotes additional unknown factors
T49 1694-1710 other_name denotes maximal activity