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PubMed:7721831 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 483-494 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T2 840-849 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T4 2057-2068 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT

sentences

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Identification of a novel glycosaminoglycan core-like molecule.
T2 64-67 Sentence denotes II.
T3 68-129 Sentence denotes Alpha-GalNAc-capped xylosides can be made by many cell types.
T4 130-179 Sentence denotes The accompanying article (Manzi, A., Salimath, P.
T5 180-193 Sentence denotes V., Spiro, R.
T6 194-208 Sentence denotes C., Keifer, P.
T7 209-227 Sentence denotes A., and Freeze, H.
T8 228-240 Sentence denotes H. (1995) J.
T9 241-246 Sentence denotes Biol.
T10 247-252 Sentence denotes Chem.
T11 253-414 Sentence denotes 270, 9154-9163) reported the complete structure of a novel molecule made by human melanoma cells incubated with 1 mM 4-methylumbelliferyl-beta Xyl (Xyl beta MU).
T12 415-691 Sentence denotes The product resembles a common pentasaccharide core region found in chondroitin/dermatan sulfate glycosaminoglycans, except that a terminal alpha-Gal-NAc residue is found in a location normally occupied by beta-GalNAc in these chains or alpha-GlcNAc in heparan sulfate chains.
T13 692-829 Sentence denotes In this paper we show that several other human cancer cell lines and Chinese hamster ovary cells also make alpha-GalNAc-capped xylosides.
T14 830-1001 Sentence denotes The [6-3H]galactose-labeled Xyl beta MU product binds to immobilized alpha-GalNAc-specific lectin from Helix pomatia and the binding is competed by GalNAc, but not by Glc.
T15 1002-1116 Sentence denotes Binding to the lectin is destroyed by digestion with alpha-N-acetylgalactosaminidase, but not beta-hexosaminidase.
T16 1117-1322 Sentence denotes The nature of the aglycone influences the amount and relative proportion of this material made, with p-nitrophenyl-beta-xyloside being a better promoter of alpha-GalNAc-terminated product than Xyl beta MU.
T17 1323-1586 Sentence denotes This novel oligosaccharide accounts for 45-65% of xyloside-based products made by both human melanoma and Chinese hamster ovary cells when they are incubated with 30 microM Xyl beta MU, but at 1 mM both the total amount and the proportion decreases to only 5-10%.
T18 1587-1695 Sentence denotes In both cell lines this product is replaced by a corresponding amount of Sia alpha 2,3Gal beta 4Xyl beta MU.
T19 1696-1871 Sentence denotes Preferential synthesis of the alpha-GalNAc-capped material at very low xyloside concentration argues that it is a normal biosynthetic product and not an experimental artifact.
T20 1872-1979 Sentence denotes This pentasaccharide may be a previously unrecognized intermediate in glycosaminoglycan chain biosynthesis.
T21 1980-2188 Sentence denotes Since this alpha-GalNAc residue occurs at a position that determines whether chondroitin or heparan chains are added to the acceptor, it may influence the timing, type, and extent of further chain elongation.
T1 0-63 Sentence denotes Identification of a novel glycosaminoglycan core-like molecule.
T2 64-67 Sentence denotes II.
T3 68-129 Sentence denotes Alpha-GalNAc-capped xylosides can be made by many cell types.
T4 130-179 Sentence denotes The accompanying article (Manzi, A., Salimath, P.
T5 180-193 Sentence denotes V., Spiro, R.
T6 194-208 Sentence denotes C., Keifer, P.
T7 209-227 Sentence denotes A., and Freeze, H.
T8 228-240 Sentence denotes H. (1995) J.
T9 241-246 Sentence denotes Biol.
T10 247-252 Sentence denotes Chem.
T11 253-414 Sentence denotes 270, 9154-9163) reported the complete structure of a novel molecule made by human melanoma cells incubated with 1 mM 4-methylumbelliferyl-beta Xyl (Xyl beta MU).
T12 415-691 Sentence denotes The product resembles a common pentasaccharide core region found in chondroitin/dermatan sulfate glycosaminoglycans, except that a terminal alpha-Gal-NAc residue is found in a location normally occupied by beta-GalNAc in these chains or alpha-GlcNAc in heparan sulfate chains.
T13 692-829 Sentence denotes In this paper we show that several other human cancer cell lines and Chinese hamster ovary cells also make alpha-GalNAc-capped xylosides.
T14 830-1001 Sentence denotes The [6-3H]galactose-labeled Xyl beta MU product binds to immobilized alpha-GalNAc-specific lectin from Helix pomatia and the binding is competed by GalNAc, but not by Glc.
T15 1002-1116 Sentence denotes Binding to the lectin is destroyed by digestion with alpha-N-acetylgalactosaminidase, but not beta-hexosaminidase.
T16 1117-1322 Sentence denotes The nature of the aglycone influences the amount and relative proportion of this material made, with p-nitrophenyl-beta-xyloside being a better promoter of alpha-GalNAc-terminated product than Xyl beta MU.
T17 1323-1586 Sentence denotes This novel oligosaccharide accounts for 45-65% of xyloside-based products made by both human melanoma and Chinese hamster ovary cells when they are incubated with 30 microM Xyl beta MU, but at 1 mM both the total amount and the proportion decreases to only 5-10%.
T18 1587-1695 Sentence denotes In both cell lines this product is replaced by a corresponding amount of Sia alpha 2,3Gal beta 4Xyl beta MU.
T19 1696-1871 Sentence denotes Preferential synthesis of the alpha-GalNAc-capped material at very low xyloside concentration argues that it is a normal biosynthetic product and not an experimental artifact.
T20 1872-1979 Sentence denotes This pentasaccharide may be a previously unrecognized intermediate in glycosaminoglycan chain biosynthesis.
T21 1980-2188 Sentence denotes Since this alpha-GalNAc residue occurs at a position that determines whether chondroitin or heparan chains are added to the acceptor, it may influence the timing, type, and extent of further chain elongation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 483-494 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T2 840-849 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T3 840-849 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T4 2057-2068 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 483-494 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T2 668-683 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T3 2057-2068 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 658-664 chem:24139 denotes GlcNAc

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 74-80 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 483-494 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T3 561-568 Glycan denotes Gal-NAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 626-632 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 805-811 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 905-911 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 978-984 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T8 1279-1285 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T9 1732-1738 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T10 1997-2003 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T11 2057-2068 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T16 668-683 Glycan denotes heparan sulfate https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 335-343 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T2 739-745 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 1416-1424 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 74-80 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 483-494 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T3 561-568 Glycan denotes Gal-NAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 626-632 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 805-811 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 905-911 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 978-984 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T8 1279-1285 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T9 1732-1738 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T10 1997-2003 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T11 2057-2068 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T21 668-683 Glycan denotes heparan sulfate https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 483-494 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 668-683 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 2057-2068 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 335-343 Phenotype denotes melanoma HP:0002861
T2 739-745 Phenotype denotes cancer HP:0002664
T3 1416-1424 Phenotype denotes melanoma HP:0002861

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 739-750 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 777-782 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 933-938 Body_part denotes Helix http://purl.obolibrary.org/obo/UBERON_0002488
T3 1445-1450 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 329-334 Organism denotes human 9606
T2 733-738 Organism denotes human 9606
T3 761-776 Organism denotes Chinese hamster 10029
T4 933-946 Organism denotes Helix pomatia 6536
T5 1410-1415 Organism denotes human 9606
T6 1429-1444 Organism denotes Chinese hamster 10029

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Identification of a novel glycosaminoglycan core-like molecule.
T2 64-67 Sentence denotes II.
T3 68-129 Sentence denotes Alpha-GalNAc-capped xylosides can be made by many cell types.
T4 130-414 Sentence denotes The accompanying article (Manzi, A., Salimath, P. V., Spiro, R. C., Keifer, P. A., and Freeze, H. H. (1995) J. Biol. Chem. 270, 9154-9163) reported the complete structure of a novel molecule made by human melanoma cells incubated with 1 mM 4-methylumbelliferyl-beta Xyl (Xyl beta MU).
T5 415-691 Sentence denotes The product resembles a common pentasaccharide core region found in chondroitin/dermatan sulfate glycosaminoglycans, except that a terminal alpha-Gal-NAc residue is found in a location normally occupied by beta-GalNAc in these chains or alpha-GlcNAc in heparan sulfate chains.
T6 692-829 Sentence denotes In this paper we show that several other human cancer cell lines and Chinese hamster ovary cells also make alpha-GalNAc-capped xylosides.
T7 830-1116 Sentence denotes The [6-3H]galactose-labeled Xyl beta MU product binds to immobilized alpha-GalNAc-specific lectin from Helix pomatia and the binding is competed by GalNAc, but not by Glc. Binding to the lectin is destroyed by digestion with alpha-N-acetylgalactosaminidase, but not beta-hexosaminidase.
T8 1117-1322 Sentence denotes The nature of the aglycone influences the amount and relative proportion of this material made, with p-nitrophenyl-beta-xyloside being a better promoter of alpha-GalNAc-terminated product than Xyl beta MU.
T9 1323-1586 Sentence denotes This novel oligosaccharide accounts for 45-65% of xyloside-based products made by both human melanoma and Chinese hamster ovary cells when they are incubated with 30 microM Xyl beta MU, but at 1 mM both the total amount and the proportion decreases to only 5-10%.
T10 1587-1695 Sentence denotes In both cell lines this product is replaced by a corresponding amount of Sia alpha 2,3Gal beta 4Xyl beta MU.
T11 1696-1871 Sentence denotes Preferential synthesis of the alpha-GalNAc-capped material at very low xyloside concentration argues that it is a normal biosynthetic product and not an experimental artifact.
T12 1872-1979 Sentence denotes This pentasaccharide may be a previously unrecognized intermediate in glycosaminoglycan chain biosynthesis.
T13 1980-2188 Sentence denotes Since this alpha-GalNAc residue occurs at a position that determines whether chondroitin or heparan chains are added to the acceptor, it may influence the timing, type, and extent of further chain elongation.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 483-494 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 668-683 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 2057-2068 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Identification of a novel glycosaminoglycan core-like molecule.
T2 64-67 Sentence denotes II.
T3 68-129 Sentence denotes Alpha-GalNAc-capped xylosides can be made by many cell types.
T4 130-414 Sentence denotes The accompanying article (Manzi, A., Salimath, P. V., Spiro, R. C., Keifer, P. A., and Freeze, H. H. (1995) J. Biol. Chem. 270, 9154-9163) reported the complete structure of a novel molecule made by human melanoma cells incubated with 1 mM 4-methylumbelliferyl-beta Xyl (Xyl beta MU).
T5 415-691 Sentence denotes The product resembles a common pentasaccharide core region found in chondroitin/dermatan sulfate glycosaminoglycans, except that a terminal alpha-Gal-NAc residue is found in a location normally occupied by beta-GalNAc in these chains or alpha-GlcNAc in heparan sulfate chains.
T6 692-829 Sentence denotes In this paper we show that several other human cancer cell lines and Chinese hamster ovary cells also make alpha-GalNAc-capped xylosides.
T7 830-1116 Sentence denotes The [6-3H]galactose-labeled Xyl beta MU product binds to immobilized alpha-GalNAc-specific lectin from Helix pomatia and the binding is competed by GalNAc, but not by Glc. Binding to the lectin is destroyed by digestion with alpha-N-acetylgalactosaminidase, but not beta-hexosaminidase.
T8 1117-1322 Sentence denotes The nature of the aglycone influences the amount and relative proportion of this material made, with p-nitrophenyl-beta-xyloside being a better promoter of alpha-GalNAc-terminated product than Xyl beta MU.
T9 1323-1586 Sentence denotes This novel oligosaccharide accounts for 45-65% of xyloside-based products made by both human melanoma and Chinese hamster ovary cells when they are incubated with 30 microM Xyl beta MU, but at 1 mM both the total amount and the proportion decreases to only 5-10%.
T10 1587-1695 Sentence denotes In both cell lines this product is replaced by a corresponding amount of Sia alpha 2,3Gal beta 4Xyl beta MU.
T11 1696-1871 Sentence denotes Preferential synthesis of the alpha-GalNAc-capped material at very low xyloside concentration argues that it is a normal biosynthetic product and not an experimental artifact.
T12 1872-1979 Sentence denotes This pentasaccharide may be a previously unrecognized intermediate in glycosaminoglycan chain biosynthesis.
T13 1980-2188 Sentence denotes Since this alpha-GalNAc residue occurs at a position that determines whether chondroitin or heparan chains are added to the acceptor, it may influence the timing, type, and extent of further chain elongation.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 335-343 Disease denotes melanoma MONDO:0005105
T2 739-745 Disease denotes cancer MONDO:0004992
T3 1416-1424 Disease denotes melanoma MONDO:0005105

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 777-782 Body_part denotes ovary FMA:7209
T2 933-938 Body_part denotes Helix FMA:60992
T3 1445-1450 Body_part denotes ovary FMA:7209

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 329-334 OrganismTaxon denotes human 9606
T2 733-738 OrganismTaxon denotes human 9606
T3 761-776 OrganismTaxon denotes Chinese hamster 10029
T4 933-946 OrganismTaxon denotes Helix pomatia 6536
T5 1410-1415 OrganismTaxon denotes human 9606
T6 1429-1444 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 777-782 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 933-938 Body_part denotes Helix http://purl.obolibrary.org/obo/UBERON_0002488
T3 1445-1450 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 335-343 Phenotype denotes melanoma HP:0002861
T2 739-745 Phenotype denotes cancer HP:0002664
T3 1416-1424 Phenotype denotes melanoma HP:0002861

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 739-750 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064