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sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer.
T2 84-140 Sentence denotes Erythroid lineage and developmental stage specificities.
T3 141-309 Sentence denotes Transcriptional regulation of the human alpha-like globin genes, embryonic zeta 2 and adult alpha, during erythroid development is mediated by a distal enhancer, HS-40.
T4 310-511 Sentence denotes Previous protein-DNA binding studies have shown that HS-40 consists of multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner.
T5 512-692 Sentence denotes We have systematically analyzed the functional roles of these factor binding motifs of HS-40 by site-directed mutagenesis and transient expression assay in erythroid cell cultures.
T6 693-936 Sentence denotes Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells.
T7 937-1241 Sentence denotes On the other hand, the 3'NF-E2/AP1 motif is able to exert both positive and negative regulatory effects on the zeta 2-globin promoter activity in K562 cells, and this dual function appears to be modulated through differential binding of the ubiquitous AP1 factors and the erythroid-enriched NF-E2 factor.
T8 1242-1437 Sentence denotes Mutation in the GATA-1(d) motif, which exhibits an adult erythroid-specific genomic footprint, decreases the HS-40 enhancer function in dimethyl sulfoxide-induced MEL cells but not in K562 cells.
T9 1438-1516 Sentence denotes These studies have defined the regulatory roles of the different HS-40 motifs.
T10 1517-1803 Sentence denotes The remarkable correlation between genomic footprinting data and the mutagenesis results also suggests that the erythroid lineage- and developmental stage-specific regulation of human alpha-like globin promoters is indeed modulated by stable binding of specific nuclear factors in vivo.
T1 0-83 Sentence denotes Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer.
T2 84-140 Sentence denotes Erythroid lineage and developmental stage specificities.
T3 141-309 Sentence denotes Transcriptional regulation of the human alpha-like globin genes, embryonic zeta 2 and adult alpha, during erythroid development is mediated by a distal enhancer, HS-40.
T4 310-511 Sentence denotes Previous protein-DNA binding studies have shown that HS-40 consists of multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner.
T5 512-692 Sentence denotes We have systematically analyzed the functional roles of these factor binding motifs of HS-40 by site-directed mutagenesis and transient expression assay in erythroid cell cultures.
T6 693-936 Sentence denotes Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells.
T7 937-1241 Sentence denotes On the other hand, the 3'NF-E2/AP1 motif is able to exert both positive and negative regulatory effects on the zeta 2-globin promoter activity in K562 cells, and this dual function appears to be modulated through differential binding of the ubiquitous AP1 factors and the erythroid-enriched NF-E2 factor.
T8 1242-1437 Sentence denotes Mutation in the GATA-1(d) motif, which exhibits an adult erythroid-specific genomic footprint, decreases the HS-40 enhancer function in dimethyl sulfoxide-induced MEL cells but not in K562 cells.
T9 1438-1516 Sentence denotes These studies have defined the regulatory roles of the different HS-40 motifs.
T10 1517-1803 Sentence denotes The remarkable correlation between genomic footprinting data and the mutagenesis results also suggests that the erythroid lineage- and developmental stage-specific regulation of human alpha-like globin promoters is indeed modulated by stable binding of specific nuclear factors in vivo.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 950-954 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 20-50 DNA denotes in vivo footprinted DNA motifs
T2 61-82 DNA denotes alpha-globin enhancer
T3 175-204 DNA denotes human alpha-like globin genes
T4 206-222 DNA denotes embryonic zeta 2
T5 227-238 DNA denotes adult alpha
T6 286-301 DNA denotes distal enhancer
T7 303-308 DNA denotes HS-40
T8 363-368 DNA denotes HS-40
T9 390-419 DNA denotes nuclear factor binding motifs
T10 574-595 DNA denotes factor binding motifs
T11 599-604 DNA denotes HS-40
T12 668-691 cell_line denotes erythroid cell cultures
T13 708-729 DNA denotes HS-40 enhancer motifs
T14 731-742 DNA denotes 5'NF-E2/AP1
T15 744-749 DNA denotes GT II
T16 755-764 DNA denotes GATA-1(c)
T17 790-812 DNA denotes zeta 2-globin promoter
T18 825-861 cell_line denotes embryonic/fetal erythroid K562 cells
T19 870-897 DNA denotes adult alpha-globin promoter
T20 910-935 cell_line denotes adult erythroid MEL cells
T21 960-977 DNA denotes 3'NF-E2/AP1 motif
T22 1048-1070 DNA denotes zeta 2-globin promoter
T23 1083-1093 cell_line denotes K562 cells
T24 1178-1200 protein denotes ubiquitous AP1 factors
T25 1209-1240 protein denotes erythroid-enriched NF-E2 factor
T26 1258-1273 DNA denotes GATA-1(d) motif
T27 1293-1335 DNA denotes adult erythroid-specific genomic footprint
T28 1351-1365 DNA denotes HS-40 enhancer
T29 1378-1414 cell_line denotes dimethyl sulfoxide-induced MEL cells
T30 1426-1436 cell_line denotes K562 cells
T31 1503-1515 DNA denotes HS-40 motifs
T32 1695-1728 DNA denotes human alpha-like globin promoters
T33 1770-1794 protein denotes specific nuclear factors

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 58-82 NP denotes an alpha-globin enhancer
C2 171-204 NP denotes the human alpha-like globin genes
C3 206-238 NP denotes embryonic zeta 2 and adult alpha
C4 284-301 NP denotes a distal enhancer
C5 303-308 NP denotes HS-40
C6 363-368 NP denotes HS-40
C8 381-419 NP denotes multiple nuclear factor binding motifs
C9 420-424 NP denotes that
C7 381-510 NP denotes multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner
C11 599-604 NP denotes HS-40
C10 568-604 NP denotes these factor binding motifs of HS-40
C13 702-729 NP denotes these HS-40 enhancer motifs
C12 693-729 NP denotes Three of these HS-40 enhancer motifs
C14 731-764 NP denotes 5'NF-E2/AP1, GT II, and GATA-1(c)
C15 786-821 NP denotes the zeta 2-globin promoter activity
C16 825-861 NP denotes embryonic/fetal erythroid K562 cells
C17 1044-1079 NP denotes the zeta 2-globin promoter activity
C18 1083-1093 NP denotes K562 cells
C19 1242-1273 NP denotes Mutation in the GATA-1(d) motif
C20 1275-1280 NP denotes which
C21 1426-1436 NP denotes K562 cells
C22 1489-1515 NP denotes the different HS-40 motifs
R1 C3 C2 coref-appos embryonic zeta 2 and adult alpha,the human alpha-like globin genes
R2 C4 C1 coref-ident a distal enhancer,an alpha-globin enhancer
R3 C5 C4 coref-appos HS-40,a distal enhancer
R4 C6 C5 coref-ident HS-40,HS-40
R5 C9 C8 coref-relat that,multiple nuclear factor binding motifs
R6 C11 C6 coref-ident HS-40,HS-40
R7 C10 C7 coref-ident these factor binding motifs of HS-40,multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner
R8 C13 C10 coref-ident these HS-40 enhancer motifs,these factor binding motifs of HS-40
R9 C14 C12 coref-appos "5'NF-E2/AP1, GT II, and GATA-1(c)",Three of these HS-40 enhancer motifs
R10 C17 C15 coref-ident the zeta 2-globin promoter activity,the zeta 2-globin promoter activity
R11 C18 C16 coref-ident K562 cells,embryonic/fetal erythroid K562 cells
R12 C20 C19 coref-relat which,Mutation in the GATA-1(d) motif
R13 C21 C18 coref-ident K562 cells,K562 cells
R14 C22 C10 coref-ident the different HS-40 motifs,these factor binding motifs of HS-40

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-83 Sentence denotes Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer.
S2 84-140 Sentence denotes Erythroid lineage and developmental stage specificities.
S3 141-309 Sentence denotes Transcriptional regulation of the human alpha-like globin genes, embryonic zeta 2 and adult alpha, during erythroid development is mediated by a distal enhancer, HS-40.
S4 310-511 Sentence denotes Previous protein-DNA binding studies have shown that HS-40 consists of multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner.
S5 512-692 Sentence denotes We have systematically analyzed the functional roles of these factor binding motifs of HS-40 by site-directed mutagenesis and transient expression assay in erythroid cell cultures.
S6 693-936 Sentence denotes Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells.
S7 937-1241 Sentence denotes On the other hand, the 3'NF-E2/AP1 motif is able to exert both positive and negative regulatory effects on the zeta 2-globin promoter activity in K562 cells, and this dual function appears to be modulated through differential binding of the ubiquitous AP1 factors and the erythroid-enriched NF-E2 factor.
S8 1242-1437 Sentence denotes Mutation in the GATA-1(d) motif, which exhibits an adult erythroid-specific genomic footprint, decreases the HS-40 enhancer function in dimethyl sulfoxide-induced MEL cells but not in K562 cells.
S9 1438-1516 Sentence denotes These studies have defined the regulatory roles of the different HS-40 motifs.
S10 1517-1803 Sentence denotes The remarkable correlation between genomic footprinting data and the mutagenesis results also suggests that the erythroid lineage- and developmental stage-specific regulation of human alpha-like globin promoters is indeed modulated by stable binding of specific nuclear factors in vivo.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 20-50 DNA_family_or_group denotes in vivo footprinted DNA motifs
T2 61-82 DNA_domain_or_region denotes alpha-globin enhancer
T3 84-101 other_name denotes Erythroid lineage
T4 141-167 other_name denotes Transcriptional regulation
T5 175-204 DNA_family_or_group denotes human alpha-like globin genes
T6 206-222 DNA_domain_or_region denotes embryonic zeta 2
T7 227-238 DNA_domain_or_region denotes adult alpha
T8 247-268 other_name denotes erythroid development
T9 286-301 DNA_domain_or_region denotes distal enhancer
T10 303-308 DNA_domain_or_region denotes HS-40
T11 319-346 other_name denotes protein-DNA binding studies
T12 363-368 DNA_domain_or_region denotes HS-40
T13 390-419 DNA_family_or_group denotes nuclear factor binding motifs
T14 574-595 DNA_domain_or_region denotes factor binding motifs
T15 599-604 DNA_domain_or_region denotes HS-40
T16 608-633 other_name denotes site-directed mutagenesis
T17 638-664 other_name denotes transient expression assay
T18 668-691 cell_line denotes erythroid cell cultures
T19 708-713 DNA_domain_or_region denotes HS-40
T20 731-742 DNA_domain_or_region denotes 5'NF-E2/AP1
T21 744-749 DNA_domain_or_region denotes GT II
T22 755-764 DNA_domain_or_region denotes GATA-1(c)
T23 790-812 DNA_domain_or_region denotes zeta 2-globin promoter
T24 825-861 cell_line denotes embryonic/fetal erythroid K562 cells
T25 870-881 DNA_domain_or_region denotes adult alpha
T26 910-935 cell_line denotes adult erythroid MEL cells
T27 960-977 DNA_domain_or_region denotes 3'NF-E2/AP1 motif
T28 1022-1040 other_name denotes regulatory effects
T29 1048-1070 DNA_domain_or_region denotes zeta 2-globin promoter
T30 1083-1093 cell_line denotes K562 cells
T31 1178-1200 protein_family_or_group denotes ubiquitous AP1 factors
T32 1209-1240 protein_molecule denotes erythroid-enriched NF-E2 factor
T33 1258-1273 DNA_domain_or_region denotes GATA-1(d) motif
T34 1293-1335 DNA_domain_or_region denotes adult erythroid-specific genomic footprint
T35 1351-1356 DNA_domain_or_region denotes HS-40
T36 1378-1414 cell_line denotes dimethyl sulfoxide-induced MEL cells
T37 1426-1436 cell_line denotes K562 cells
T38 1503-1508 DNA_domain_or_region denotes HS-40
T39 1552-1577 other_name denotes genomic footprinting data
T40 1586-1605 other_name denotes mutagenesis results
T41 1695-1728 DNA_domain_or_region denotes human alpha-like globin promoters
T42 1770-1794 protein_family_or_group denotes specific nuclear factors

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 950-954 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 175-180 OrganismTaxon denotes human 9606
T2 1695-1700 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 950-954 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398